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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
ATF6-mediated unfolded protein response +   
ER overload response +   
PERK-mediated unfolded protein response +   
SREBP signaling pathway +   
The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.

Synonyms
Exact Synonyms: ER to nucleus sterol response pathway ;   ER-nuclear sterol response pathway ;   SREBP signalling ;   SREBP target gene transcriptional activation ;   SREBP-mediated signalling pathway ;   endoplasmic reticulum to nucleus sterol response pathway ;   endoplasmic reticulum-nuclear sterol response pathway ;   positive regulation of sterol regulatory element binding protein target gene transcription ;   positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response ;   sterol depletion response, SREBP target gene transcriptional activation ;   sterol response element binding protein signaling pathway ;   up regulation of sterol regulatory element binding protein target gene transcription ;   upregulation of sterol regulatory element binding protein target gene transcription
Narrow Synonyms: activation of sterol regulatory element binding protein target gene transcription ;   positive regulation of transcription via sterol regulatory element binding ;   positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway ;   stimulation of sterol regulatory element binding protein target gene transcription
Broad Synonyms: sterol regulatory element binding protein target gene transcriptional activation
Related Synonyms: SREBP-mediated signaling pathway
Alternate IDs: GO:0006994 ;   GO:0030967 ;   GO:0035104
Definition Sources: GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871

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