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ONTOLOGY REPORT - ANNOTATIONS

Term:insulin-like growth factor receptor activity
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Accession:GO:0005010 term browser browse the term
Definition:Combining with insulin-like growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
Comment:Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888.
Synonyms:exact_synonym: IGF receptor activity;   IGF-activated receptor activity;   insulin-like growth factor-activated receptor activity


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insulin-like growth factor receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alk ALK receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034 		JBrowse link
G Axl Axl receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Csf1r colony stimulating factor 1 receptor enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Egfr epidermal growth factor receptor enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Epha1 Eph receptor A1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846 		JBrowse link
G Epha2 Eph receptor A2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Epha3 Eph receptor A3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900 		JBrowse link
G Epha4 Eph receptor A4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Epha5 EPH receptor A5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317 		JBrowse link
G Epha6 Eph receptor A6 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr11:39,757,501...40,708,901
Ensembl chr11:39,757,181...40,698,311 		JBrowse link
G Epha7 Eph receptor A7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112 		JBrowse link
G Epha8 Eph receptor A8 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399 		JBrowse link
G Ephb1 Eph receptor B1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839 		JBrowse link
G Ephb2 Eph receptor B2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Ephb3 Eph receptor B3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Ephb4 EPH receptor B4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor enables TAS
IDA
ISO
ISS
IEA		 (PMID:7679099)
GO_REF:0000024
MGI:96434 (PMID:19302825), (PMID:32439763), (PMID:33567274)
GO_REF:0000003		 RGD
UniProt		 PMID:7679099 PMID:19302825 PMID:32439763 PMID:33567274 PMID:11572795 More... GO_REF:0000003 GO_REF:0000024, RGD:70266, RGD:12904886 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor TAS RGD PMID:12596253 RGD:1298967 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Insr insulin receptor enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Insrr insulin receptor-related receptor enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800 		JBrowse link
G Kdr kinase insert domain receptor enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Ltk leukocyte receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:106,734,675...106,741,552
Ensembl chr 3:106,734,676...106,743,369 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mst1r macrophage stimulating 1 receptor enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:108,596,100...108,611,441
Ensembl chr 8:108,597,299...108,612,455 		JBrowse link
G Musk muscle associated receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Ret ret proto-oncogene enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865 		JBrowse link
G Tek TEK receptor tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804 		JBrowse link
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:132,000,013...132,019,658
Ensembl chr 5:132,000,015...132,019,592 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:106,777,686...106,797,154
Ensembl chr 3:106,777,635...106,797,142 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      catalytic activity, acting on a protein 2509
        protein kinase activity 622
          transmembrane receptor protein kinase activity 79
            transmembrane receptor protein tyrosine kinase activity 61
              insulin-like growth factor receptor activity 49
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      transferase activity 2397
        transferase activity, transferring phosphorus-containing groups 969
          kinase activity 802
            protein kinase activity 622
              protein tyrosine kinase activity 138
                transmembrane receptor protein tyrosine kinase activity 61
                  insulin-like growth factor receptor activity 49
paths to the root