Epha7 (Eph receptor A7) - Rat Genome Database

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Gene: Epha7 (Eph receptor A7) Rattus norvegicus
Analyze
Symbol: Epha7
Name: Eph receptor A7
RGD ID: 70957
Description: Enables ephrin receptor binding activity and protein tyrosine kinase activity. Involved in phosphorylation and positive regulation of apoptotic process. Located in dendrite; neuronal cell body; and postsynaptic membrane. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density membrane. Orthologous to human EPHA7 (EPH receptor A7); PARTICIPATES IN altered ephrin - ephrin receptor bidirectional signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EHK-3; EPH homology kinase 3; ephrin receptor EphA7; ephrin type-A receptor 7; tyrosine-protein kinase receptor EHK-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8547,771,776 - 47,925,189 (+)NCBIGRCr8
mRatBN7.2542,975,353 - 43,128,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl542,975,405 - 43,127,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx545,088,903 - 45,248,749 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0546,688,133 - 46,847,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0546,637,329 - 46,797,189 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0543,602,744 - 43,761,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl543,603,043 - 43,757,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0548,229,993 - 48,390,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4544,728,037 - 44,878,332 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1544,728,215 - 44,878,511 (+)NCBI
Celera541,793,958 - 41,943,704 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
clozapine  (ISO)
cocaine  (EXP)
dexamethasone  (EXP)
diethyl malate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fonofos  (ISO)
genistein  (EXP)
gentamycin  (EXP)
GW 4064  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
ponatinib  (ISO)
progesterone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
warfarin  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (IBA)
brain development  (IEA,ISO,ISS)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
branching morphogenesis of a nerve  (IEA,ISO,ISS)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
ephrin receptor signaling pathway  (IBA,IEA,ISO,ISS)
epidermal growth factor receptor signaling pathway  (IEA)
fibroblast growth factor receptor signaling pathway  (IEA)
hepatocyte growth factor receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
modulation of chemical synaptic transmission  (IEA,ISO)
negative chemotaxis  (IEA,ISS)
negative regulation of collateral sprouting  (IEA,ISO)
negative regulation of synapse assembly  (IEA,ISO)
nephric duct morphogenesis  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
obsolete regulation of cysteine-type endopeptidase activity  (ISO)
phosphorylation  (IDA)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of apoptotic process  (IMP)
positive regulation of neuron apoptotic process  (IEA,ISO,ISS)
positive regulation of protein phosphorylation  (ISO)
regulation of cell-cell adhesion  (IEA,ISO,ISS)
regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
regulation of peptidyl-tyrosine phosphorylation  (ISO,ISS)
regulation of postsynapse organization  (IEA,ISO)
regulation of protein autophosphorylation  (ISO,ISS)
retinal ganglion cell axon guidance  (IEA,ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat. Amegandjin CA, etal., J Comp Neurol. 2016 Aug 15;524(12):2462-78. doi: 10.1002/cne.23962. Epub 2016 Feb 26.
2. The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. Buchert M, etal., J Cell Biol. 1999 Jan 25;144(2):361-71.
3. Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery. Figueroa JD, etal., J Neurosci Res. 2006 Nov 15;84(7):1438-51.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum. Janis LS, etal., J Neurosci. 1999 Jun 15;19(12):4962-71.
6. Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction. Lai KO, etal., Mol Cell Neurosci. 2001 Jun;17(6):1034-47.
7. Distinct expression patterns of eph receptors and ephrins relate to the structural organization of the adult rat peripheral vestibular system. Matsunaga T, etal., Eur J Neurosci 2000 May;12(5):1599-616.
8. Gene Data Set MGD Curation, June 12, 2002
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The role of ephrins and Eph receptors in cancer. Surawska H, etal., Cytokine Growth Factor Rev 2004 Dec;15(6):419-33.
15. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Torres R, etal., Neuron. 1998 Dec;21(6):1453-63.
16. Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family. Valenzuela DM, etal., Oncogene 1995 Apr 20;10(8):1573-80.
Additional References at PubMed
PMID:11089974   PMID:15902206   PMID:15996548   PMID:16301174   PMID:17726105   PMID:19036963   PMID:20576928   PMID:23348681   PMID:24707048   PMID:25139858   PMID:27405707   PMID:30292674  
PMID:32396496  


Genomics

Comparative Map Data
Epha7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8547,771,776 - 47,925,189 (+)NCBIGRCr8
mRatBN7.2542,975,353 - 43,128,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl542,975,405 - 43,127,112 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx545,088,903 - 45,248,749 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0546,688,133 - 46,847,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0546,637,329 - 46,797,189 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0543,602,744 - 43,761,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl543,603,043 - 43,757,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0548,229,993 - 48,390,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4544,728,037 - 44,878,332 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1544,728,215 - 44,878,511 (+)NCBI
Celera541,793,958 - 41,943,704 (+)NCBICelera
Cytogenetic Map5q21NCBI
EPHA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38693,240,020 - 93,419,559 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl693,240,020 - 93,419,687 (-)EnsemblGRCh38hg38GRCh38
GRCh37693,949,738 - 94,129,277 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36694,007,860 - 94,185,993 (-)NCBINCBI36Build 36hg18NCBI36
Build 34694,007,859 - 94,185,993NCBI
Celera694,370,456 - 94,550,043 (-)NCBICelera
Cytogenetic Map6q16.1NCBI
HuRef691,169,863 - 91,349,539 (-)NCBIHuRef
CHM1_1694,047,125 - 94,226,695 (-)NCBICHM1_1
T2T-CHM13v2.0694,452,021 - 94,631,561 (-)NCBIT2T-CHM13v2.0
Epha7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39428,811,840 - 28,969,391 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl428,813,131 - 28,967,499 (+)EnsemblGRCm39 Ensembl
GRCm38428,813,066 - 28,967,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl428,813,131 - 28,967,499 (+)EnsemblGRCm38mm10GRCm38
MGSCv37428,740,295 - 28,894,649 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36428,981,940 - 29,133,870 (+)NCBIMGSCv36mm8
Celera428,584,324 - 28,738,712 (+)NCBICelera
Cytogenetic Map4A4NCBI
cM Map412.42NCBI
Epha7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541119,650,515 - 19,815,512 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541119,652,146 - 19,815,418 (-)NCBIChiLan1.0ChiLan1.0
EPHA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25113,349,035 - 113,527,613 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16111,243,468 - 111,422,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0691,143,240 - 91,322,040 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1694,392,353 - 94,563,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl694,392,353 - 94,566,716 (-)Ensemblpanpan1.1panPan2
EPHA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11252,134,775 - 52,305,163 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1252,137,605 - 52,305,162 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1251,943,814 - 52,113,431 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01252,942,277 - 53,113,070 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1252,945,000 - 53,113,162 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11252,278,827 - 52,448,685 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01252,154,143 - 52,325,433 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01252,347,435 - 52,517,393 (-)NCBIUU_Cfam_GSD_1.0
Epha7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494686,997,992 - 87,164,862 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936812698,533 - 865,481 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936812698,548 - 865,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl160,771,572 - 60,944,038 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1160,771,567 - 60,944,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2168,252,819 - 68,430,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11318,097,051 - 18,283,664 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1318,099,005 - 18,281,415 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040194,422,647 - 194,601,844 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624799560,432 - 754,132 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624799560,441 - 753,509 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:55
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000009899, ENSRNOT00000061033
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)53113042148841739Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
RH143595  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2542,976,331 - 42,976,511 (+)MAPPERmRatBN7.2
Rnor_6.0543,603,757 - 43,603,936NCBIRnor6.0
Rnor_5.0548,231,000 - 48,231,179UniSTSRnor5.0
RGSC_v3.4544,728,891 - 44,729,070UniSTSRGSC3.4
Celera541,794,811 - 41,794,990UniSTS
RH 3.4 Map5232.1UniSTS
Cytogenetic Map5q21UniSTS
UniSTS:266990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2543,125,075 - 43,125,217 (+)MAPPERmRatBN7.2
Rnor_6.0543,757,571 - 43,757,712NCBIRnor6.0
Rnor_5.0548,386,410 - 48,386,551UniSTSRnor5.0
RGSC_v3.4544,878,283 - 44,878,424UniSTSRGSC3.4
Celera541,943,655 - 41,943,796UniSTS
Cytogenetic Map5q21UniSTS
UniSTS:224539  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2543,108,923 - 43,109,120 (+)MAPPERmRatBN7.2
Rnor_6.0543,741,418 - 43,741,614NCBIRnor6.0
Rnor_5.0548,370,257 - 48,370,453UniSTSRnor5.0
RGSC_v3.4544,862,078 - 44,862,274UniSTSRGSC3.4
Celera541,927,502 - 41,927,698UniSTS
Cytogenetic Map5q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 88 87 56 25 56 6 214 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009899   ⟹   ENSRNOP00000009899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl542,975,413 - 43,127,112 (+)Ensembl
Rnor_6.0 Ensembl543,603,043 - 43,757,549 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102430   ⟹   ENSRNOP00000082816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl542,975,405 - 43,109,042 (+)Ensembl
RefSeq Acc Id: NM_134331   ⟹   NP_599158
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,893 - 47,925,189 (+)NCBI
mRatBN7.2542,975,401 - 43,128,703 (+)NCBI
Rnor_6.0543,602,903 - 43,757,620 (+)NCBI
Rnor_5.0548,229,993 - 48,390,037 (+)NCBI
RGSC_v3.4544,728,037 - 44,878,332 (+)RGD
Celera541,793,958 - 41,943,704 (+)RGD
Sequence:
RefSeq Acc Id: XM_006237962   ⟹   XP_006238024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,788 - 47,925,066 (+)NCBI
mRatBN7.2542,975,363 - 43,128,580 (+)NCBI
Rnor_6.0543,602,744 - 43,761,198 (+)NCBI
Rnor_5.0548,229,993 - 48,390,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237963   ⟹   XP_006238025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,815 - 47,925,066 (+)NCBI
mRatBN7.2542,975,363 - 43,128,580 (+)NCBI
Rnor_6.0543,602,744 - 43,761,198 (+)NCBI
Rnor_5.0548,229,993 - 48,390,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237964   ⟹   XP_006238026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,776 - 47,905,797 (+)NCBI
mRatBN7.2542,975,361 - 43,109,317 (+)NCBI
Rnor_6.0543,602,747 - 43,742,281 (+)NCBI
Rnor_5.0548,229,993 - 48,390,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237965   ⟹   XP_006238027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,815 - 47,924,366 (+)NCBI
mRatBN7.2542,975,353 - 43,128,703 (+)NCBI
Rnor_6.0543,602,746 - 43,760,316 (+)NCBI
Rnor_5.0548,229,993 - 48,390,037 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109224   ⟹   XP_038965152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,815 - 47,925,066 (+)NCBI
mRatBN7.2542,975,362 - 43,128,580 (+)NCBI
RefSeq Acc Id: XM_039109225   ⟹   XP_038965153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,772,898 - 47,925,066 (+)NCBI
mRatBN7.2542,976,415 - 43,128,580 (+)NCBI
RefSeq Acc Id: XM_039109226   ⟹   XP_038965154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,815 - 47,905,797 (+)NCBI
mRatBN7.2542,975,359 - 43,109,317 (+)NCBI
RefSeq Acc Id: XM_063287118   ⟹   XP_063143188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,815 - 47,925,066 (+)NCBI
RefSeq Acc Id: XM_063287119   ⟹   XP_063143189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8547,771,815 - 47,907,451 (+)NCBI
RefSeq Acc Id: NP_599158   ⟸   NM_134331
- Peptide Label: precursor
- UniProtKB: P54759 (UniProtKB/Swiss-Prot),   A6III2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238027   ⟸   XM_006237965
- Peptide Label: isoform X9
- UniProtKB: A6III1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238024   ⟸   XM_006237962
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q443 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238025   ⟸   XM_006237963
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006238026   ⟸   XM_006237964
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZVN2 (UniProtKB/TrEMBL),   A6III3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009899   ⟸   ENSRNOT00000009899
RefSeq Acc Id: XP_038965154   ⟸   XM_039109226
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038965152   ⟸   XM_039109224
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965153   ⟸   XM_039109225
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000082816   ⟸   ENSRNOT00000102430
RefSeq Acc Id: XP_063143188   ⟸   XM_063287118
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063143189   ⟸   XM_063287119
- Peptide Label: isoform X8
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54759-F1-model_v2 AlphaFold P54759 1-998 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70957 AgrOrtholog
BioCyc Gene G2FUF-41762 BioCyc
Ensembl Genes ENSRNOG00000007030 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055009805 UniProtKB/Swiss-Prot
  ENSRNOG00060013822 UniProtKB/Swiss-Prot
  ENSRNOG00065005724 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009899.6 UniProtKB/TrEMBL
  ENSRNOT00000102430.1 UniProtKB/TrEMBL
  ENSRNOT00055016616 UniProtKB/Swiss-Prot
  ENSRNOT00060023619 UniProtKB/Swiss-Prot
  ENSRNOT00065008564 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EphA7_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rcpt_TKs UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171287 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171287 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Epha7 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/Swiss-Prot
  EPH_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007030 RatGTEx
  ENSRNOG00055009805 RatGTEx
  ENSRNOG00060013822 RatGTEx
  ENSRNOG00065005724 RatGTEx
SMART EPH_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q443 ENTREZGENE, UniProtKB/TrEMBL
  A6III1 ENTREZGENE, UniProtKB/TrEMBL
  A6III2 ENTREZGENE, UniProtKB/TrEMBL
  A6III3 ENTREZGENE, UniProtKB/TrEMBL
  A6III4_RAT UniProtKB/TrEMBL
  EPHA7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Epha7  Eph receptor A7      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains a cysteine rich region and tandem fibronectin type III domains in its extracellular portion 70732
gene_expression mRNA is expressed in a developmentally-regulated fashion, restricted to nervous system in adult but more widely expressed in the embryo 70732
gene_product member of the Eph-related receptor family, the largest subfamily of receptor tyrosine kinases 70732