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pulmonary embolism - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pulmonary embolism
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Accession:DOID:9477 term browser browse the term
Definition:An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot. (DO)
Synonyms:exact_synonym: pulmonary artery embolism;   pulmonary embolisms;   pulmonary embolus;   pulmonary thromboembolism;   pulmonary thromboembolisms
 primary_id: MESH:D011655
 xref: EFO:0003827;   ICD10CM:I26;   NCI:C50713

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pulmonary embolism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase susceptibility ISO DNA:SNP:exon 6: p.R239Q G>A (rs3733890) (human) RGD PMID:37203835 RGD:329853743 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:2510358 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:heart right ventricle (rat) RGD PMID:16814320 RGD:11528528 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 IEP mRNA:increased expression:right ventricle (rat) RGD PMID:19602618 RGD:2314488 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 treatment IEP RGD PMID:23578461 RGD:9491777 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment IEP RGD PMID:23578461 RGD:9491777 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Dab2ip DAB2 interacting protein ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:CDS:intron 1 (rs7025486) (human) 		CTD
RGD		 PMID:20622881 PMID:20622881 RGD:401901599 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Edn1 endothelin 1 severity IEP protein:increased secretion:plasma (rat) RGD PMID:20559433 RGD:4144858 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12670338 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G F13a1 coagulation factor XIII A1 chain ISO RGD PMID:12958612 RGD:1581021 NCBI chr17:28,021,197...28,197,960
Ensembl chr17:27,815,702...27,992,700 		JBrowse link
G F2 coagulation factor II, thrombin susceptibility
no_association 		ISO DNA:SNP:3' utr:19911A>G (human)
DNA:SNP:3' utr:20221C>T (human) 		RGD PMID:25316662 PMID:25316662 RGD:10449427, RGD:10449427 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F5 coagulation factor V ISO RGD PMID:14996674 RGD:4892657 NCBI chr13:79,046,657...79,116,247
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G Fga fibrinogen alpha chain IEP
ISO 		protein:increased expression:blood microparticle
CTD Direct Evidence: marker/mechanism 		CTD
RGD		 PMID:10910940 PMID:22014850 RGD:5688769 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain IEP protein:increased expression:blood microparticle RGD PMID:22014850 RGD:5688769 NCBI chr 2:170,693,966...170,700,875
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgg fibrinogen gamma chain IEP protein:increased expression:blood microparticle RGD PMID:22014850 RGD:5688769 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase ISO associated with Venous Thrombosis;DNA:SNP:intron:rs9939609 (human) RGD PMID:25161014 RGD:329901770 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Hp haptoglobin IEP
ISO 		mRNA, protein:increased expression:lung, liver, serum
protein:decreased expression:blood microparticle 		RGD PMID:17203959 PMID:19943874 PMID:19566548 PMID:22014850 RGD:1626365, RGD:5147419, RGD:5147425, RGD:5688769 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Klkb1 kallikrein B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25339356 NCBI chr16:53,690,180...53,714,570
Ensembl chr16:46,958,707...46,982,053 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:19028587 PMID:15130911 RGD:1582496 NCBI chr 3:136,391,936...136,498,366
Ensembl chr 3:115,939,351...116,046,554 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IDA RGD PMID:16304337 RGD:1582630 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IDA RGD PMID:16304337 RGD:1582630 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19123085 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Nos3 nitric oxide synthase 3 IEP mRNA, protein:increased expression:lung RGD PMID:17219957 RGD:2292151 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppb natriuretic peptide B disease_progression ISO protein:increased expression:plasma RGD PMID:23562569 RGD:7247621 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:1899825 PMID:2123154 PMID:3105914 PMID:3122266 PMID:8082347 More... NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:1098216 PMID:4430106 PMID:4884574 PMID:9038699 PMID:9266785 More... NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO RGD PMID:10936861 RGD:11100014 NCBI chr18:24,038,596...24,049,061
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Pros1 protein S ISO RGD PMID:12907438 RGD:1578677 NCBI chr11:13,676,310...13,757,858
Ensembl chr11:230,696...311,286 		JBrowse link
G Serpinf2 serpin family F member 2 severity ISO RGD PMID:12911586 RGD:1580302 NCBI chr10:60,770,698...60,778,782
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Tbxa2r thromboxane A2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:7740511 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA RGD PMID:12639842 RGD:1601456 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Thbd thrombomodulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:7811989 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IEP protein:increased expression:lung RGD PMID:19915157 RGD:7240517 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Xdh xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:2510358 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Hb-ps1 RT1 class II, locus Hb, pseudogene 1 susceptibility ISO DNA:polymorphisms:cds:HLA-DPB1*0202 (human) RGD PMID:19165231 RGD:5143999 NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618 		JBrowse link
Schimke immuno-osseous dysplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smarcal1 SNF2 related chromatin remodeling annealing helicase 1 ISO
ISS 		DNA:mutations:multiple (human)
ClinVar Annotator: match by term: Schimke immuno-osseous dysplasia
OMIM:242900
CTD Direct Evidence: marker/mechanism 		ClinVar
MouseDO
CTD
OMIM
RGD		 PMID:9536098 PMID:11799392 PMID:12471207 PMID:15523612 PMID:15880370 More... RGD:1599053 NCBI chr 9:74,239,718...74,286,156
Ensembl chr 9:74,240,241...74,286,146 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19143
    disease of anatomical entity 18456
      cardiovascular system disease 5543
        vascular disease 4030
          artery disease 2862
            pulmonary artery disease 37
              pulmonary embolism 36
                Pulmonary Hypertension, Chronic Thromboembolic, without Deep Vein Thrombosis 1
                Schimke immuno-osseous dysplasia 1
                puerperal pulmonary embolism 0
                pulmonary embolism and infarction 0
paths to the root