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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:coronary stenosis
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Accession:DOID:4248 term browser browse the term
Definition:Narrowing or constriction of a coronary artery.
Synonyms:exact_synonym: coronary artery stenoses;   coronary artery stenosis;   coronary stenoses
 primary_id: MESH:D023921
 xref: EFO:1000882;   MONDO:0006715;   NCI:C80427
For additional species annotation, visit the Alliance of Genome Resources.


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coronary stenosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apln apelin ISO protein:decreased expression:plasma RGD PMID:19015606 RGD:2313942 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 ISO DNA:SNP:CDS: (Rs6486205|rs10741657|rs2060793) RGD PMID:34262949 RGD:401901074 NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759 		JBrowse link
G Edn1 endothelin 1 treatment ISO RGD PMID:10854676 RGD:8661796 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hrh2 histamine receptor H 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12721106 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Igf1 insulin-like growth factor 1 IEP mRNA:increased expression:myocyte: RGD PMID:8102103 RGD:10046053 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP mRNA:increased expression:myocyte: RGD PMID:8102103 RGD:10046053 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Itgav integrin subunit alpha V IDA RGD PMID:11922905 RGD:1582454 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 ISO protein:increased expression:coronary artery RGD PMID:32160773 RGD:243065232 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Mdk midkine IDA RGD PMID:10683378 RGD:1299187 NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Myh7 myosin heavy chain 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12721106 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nppa natriuretic peptide A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12721106 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO DNA:missense mutations:cds:p.L125V, p.S563N (human) RGD PMID:10571959 RGD:1598382 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 susceptibility ISO DNA:SNP::g.13011943A>G (rs9349379) (human) RGD PMID:22745674 RGD:401900726 NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831 		JBrowse link
G Prkce protein kinase C, epsilon ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782078 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO protein:increased expression:serum RGD PMID:15569000 RGD:1624167 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
coronary restenosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD PMID:9236417 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: therapeutic CTD PMID:12138120 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ahsp alpha hemoglobin stabilizing protein ISO mRNA:decreased expression:blood (human) RGD PMID:35144391 RGD:329961301 NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:182,880,076...182,885,506 		JBrowse link
G Bche butyrylcholinesterase susceptibility ISO DNA:polymorphism: :p.A539T (human) RGD PMID:17275003 RGD:2306778 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cdh13 cadherin 13 IEP protein:increased expression:artery, smooth muscle cell RGD PMID:12376824 RGD:2293553 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:plasma RGD PMID:14578618 RGD:1598500 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:14578618 RGD:1598500 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO RGD PMID:14529396 RGD:1581036 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Hmox1 heme oxygenase 1 susceptibility ISO RGD PMID:16020495 PMID:14529548 RGD:1598402, RGD:1580472 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:11703955 RGD:1581185 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Lox lysyl oxidase IDA RGD PMID:15218472 RGD:1581881 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA RGD PMID:15583728 RGD:1582284 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:polymorphisms:5' utr, exon:multiple (human) RGD PMID:15790942 RGD:1582150 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8662692 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment IEP RGD PMID:21139058 RGD:9685362 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16489563 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment IDA RGD PMID:7955204 RGD:10059621 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 IEP mRNA, protein:increased expression:carotid artery RGD PMID:12689918 RGD:1625501 NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382 		JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 susceptibility ISO DNA:SNP:intron:c.2222A>G (rs2074458) (human) RGD PMID:17761941 RGD:401851037 NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:12114325 PMID:16373617 RGD:1581358, RGD:1581366 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16319143 PMID:16319143 RGD:1580322 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:14740296 RGD:1580742 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ucp3 uncoupling protein 3 susceptibility ISO DNA:polymorphism:promoter:-55C>T (human) RGD PMID:17786284 RGD:2313513 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      cardiovascular system disease 5412
        vascular disease 4012
          Myocardial Ischemia 948
            Coronary Disease 626
              coronary stenosis 38
                coronary restenosis 23
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      cardiovascular system disease 5412
        vascular disease 4012
          ischemia 1500
            Myocardial Ischemia 948
              Coronary Disease 626
                coronary artery disease 600
                  coronary stenosis 38
                    coronary restenosis 23
paths to the root