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ONTOLOGY REPORT - ANNOTATIONS


Term:ginkgolide B
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Accession:CHEBI:5356 term browser browse the term
Definition:A ginkgolide in which the pro-R hydrogens at positions 6, 12, and 17 of the 8-tert-butyl-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0(1,11).0(3,7).0(7,11).0(13,17)]nonadecane-5,15,18-trione ginkgolide skeleton have been replaced by hydroxy groups.
Synonyms:exact_synonym: (1R,3R,6R,8S,10R,12R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0(1,11).0(3,7).0(7,11).0(13,17)]nonadecane-5,15,18-trione
 related_synonym: Formula=C20H24O10;   InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17?,18?,19-,20-/m1/s1;   InChIKey=SQOJOAFXDQDRGF-NNGCZKEZSA-N;   SMILES=C123[C@]4([C@]5([C@@H](C(=O)O[C@]5([C@@H]1O)[H])C)O)O[C@H]6C2([C@](C(C)(C)C)(C[C@]3(OC4=O)[H])[H])[C@H](C(=O)O6)O
 xref: CAS:15291-77-7 "ChemIDplus";   CAS:15291-77-7 "KEGG COMPOUND";   DrugBank:DB06744;   HMDB:HMDB0036861;   KEGG:C07602;   KNApSAcK:C00035830;   LIPID_MAPS_instance:LMPR0104540002 "LIPID MAPS"
 xref_mesh: MESH:C045856
 xref: PMID:15910800 "Europe PMC";   PMID:23695070 "Europe PMC";   PMID:25749575 "Europe PMC";   PMID:25755731 "Europe PMC";   PMID:25869596 "Europe PMC";   PMID:25887229 "Europe PMC";   PMID:26059355 "Europe PMC";   PMID:26064244 "Europe PMC";   PMID:26246869 "Europe PMC";   PMID:26382046 "Europe PMC";   PMID:26768586 "Europe PMC";   PMID:26775663 "Europe PMC";   PMID:26983247 "Europe PMC";   PMID:27182682 "Europe PMC";   PMID:27261579 "Europe PMC";   PMID:27306494 "Europe PMC";   PMID:27323179 "Europe PMC";   PMID:27744452 "Europe PMC";   PMID:27973574 "Europe PMC";   PMID:28234255 "Europe PMC";   PMID:28416372 "Europe PMC";   PMID:28689387 "Europe PMC";   PMID:28712049 "Europe PMC";   Reaxys:4727611 "Reaxys";   Reaxys:8173450 "Reaxys"


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ginkgolide B term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          antagonist 15784
            platelet-activating factor receptor antagonist 23
              ginkgolide B 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        lactone 5859
                                          terpene lactone 1743
                                            diterpene lactone 216
                                              ginkgolide 24
                                                ginkgolide B 23
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.