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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions |
ISO |
ginkgolide B results in increased expression of ABCB1 mRNA NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; sulforaphane inhibits the reaction [ginkgolide B results in increased expression of ABCB1 mRNA] |
CTD |
PMID:19034627 PMID:26775663 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
ginkgolide B results in increased expression of ABCC2 mRNA |
CTD |
PMID:19034627 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:19464278 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apoe |
apolipoprotein E |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein]; ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein] |
CTD |
PMID:32976958 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [APP protein results in increased abundance of Reactive Oxygen Species]; ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein] |
CTD |
PMID:19464278 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
ginkgolide B inhibits the reaction [APP protein results in increased cleavage of and results in increased activity of CASP3 protein]; ginkgolide B inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; ginkgolide B inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein] ginkgolide B inhibits the reaction [Ethanol results in increased activity of CASP3 protein] |
CTD |
PMID:19464278 PMID:21704112 PMID:26775663 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
EXP |
ginkgolide B inhibits the reaction [Ethanol results in increased expression of CYBB protein] |
CTD |
PMID:21704112 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:21329749 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases expression |
EXP |
ginkgolide B results in increased expression of and results in increased activity of CYP1A2 protein ginkgolide B results in increased expression of CYP1A2 mRNA |
CTD |
PMID:18421621 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
ginkgolide B results in increased expression of CYP2B6 mRNA |
CTD |
PMID:19034627 |
|
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions increases expression |
ISO |
NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA]; sulforaphane inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:19034627 PMID:26775663 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Fcer1g |
Fc epsilon receptor Ig |
decreases expression |
EXP |
ginkgolide B results in decreased expression of FCER1G protein |
CTD |
PMID:1834581 |
|
NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of FTH1 protein] ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of FTH1 protein] |
CTD |
PMID:32976958 |
|
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased activity of GPT protein] ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the activity of GPT protein] |
CTD |
PMID:32976958 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of GPX4 protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of GPX4 protein] |
CTD |
PMID:32976958 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of HMOX1 protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of HMOX1 protein] |
CTD |
PMID:32976958 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
CTD |
PMID:19464278 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:19464278 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein] |
CTD |
PMID:19464278 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mir214 |
microRNA 214 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [Cisplatin results in decreased expression of MIR214 mRNA]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]] |
CTD |
PMID:26768586 |
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NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
EXP |
ginkgolide B inhibits the reaction [Ethanol results in increased expression of NCF1 protein] |
CTD |
PMID:21704112 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of NFE2L2 protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in decreased expression of and affects the localization of NFE2L2 protein] |
CTD |
PMID:32976958 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
ginkgolide B inhibits the reaction [Cyclophosphamide results in increased activity of NOS2 protein] |
CTD |
PMID:9006340 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]] |
CTD |
PMID:26768586 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity multiple interactions affects localization |
ISO |
ginkgolide B results in increased activity of NR1I2 protein NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of ABCB1 mRNA]; NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] ginkgolide B affects the localization of NR1I2 protein |
CTD |
PMID:19034627 PMID:26775663 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Sele |
selectin E |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]] |
CTD |
PMID:26775663 |
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NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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G |
Shc1 |
SHC adaptor protein 1 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]] |
CTD |
PMID:26768586 |
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NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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G |
Tfrc |
transferrin receptor |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of TFRC protein] ginkgolide B inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of TFRC protein] |
CTD |
PMID:32976958 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of SELE protein]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] |
CTD |
PMID:26775663 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]; ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]; ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]; MIR214 mRNA affects the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of TRP53 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to NOX4 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin promotes the reaction [TRP53 protein binds to SHC1 promoter]]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of NOX4 mRNA]]; TRP53 protein inhibits the reaction [ginkgolide B inhibits the reaction [Cisplatin results in increased expression of SHC1 mRNA]] |
CTD |
PMID:26768586 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
ginkgolide B results in increased expression of UGT1A1 mRNA |
CTD |
PMID:19034627 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
ISO |
ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; NR1I2 protein affects the reaction [ginkgolide B inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] |
CTD |
PMID:26775663 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
CTD |
PMID:18001288 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] |
CTD |
PMID:18001288 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:21329749 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:21329749 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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