CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: iprodione
Accession: CHEBI:28909
browse the term
Definition: An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide.
Synonyms: exact_synonym: 3-(3,5-dichlorophenyl)-2,4-dioxo-N-(propan-2-yl)-imidazolidine-1-carboxamide
related_synonym: 3-(3,5-dichlorophenyl)-1-(1-methylethyl)carbamoylhydantoin; 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide; 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxoimidazolidine-1-carboxamide; 3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide; 3-(3,5-dichlorophenyl)hydantoin-1-carboxylic acid isopropylamide; Formula=C13H13Cl2N3O3; InChI=1S/C13H13Cl2N3O3/c1-7(2)16-12(20)17-6-11(19)18(13(17)21)10-4-8(14)3-9(15)5-10/h3-5,7H,6H2,1-2H3,(H,16,20); InChIKey=ONUFESLQCSAYKA-UHFFFAOYSA-N; Rovral; Rovrol; SMILES=CC(C)NC(=O)N1CC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1
alt_id: CHEBI:24871; CHEBI:8902
xref: Beilstein:895003; CAS:36734-19-7; HMDB:HMDB0031795; KEGG:C11208
xref_mesh: MESH:C033148
xref: PMID:11451425; PMID:22115616; PMID:22262495; PPDB:403; Patent:CN103053579; Patent:CN103392726; Patent:DE2149923; Patent:US3755350; Pesticides:iprodione; Reaxys:895003; UM-BBD_compID:c0635; Wikipedia:Iprodione
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO EXP
iprodione binds to and results in increased activity of AHR protein
CTD
PMID:14636698
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Anxa10
annexin A10
increases expression
ISO
iprodione results in increased expression of ANXA10 mRNA
CTD
PMID:32194361
NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
G
Ar
androgen receptor
multiple interactions affects binding
ISO
[iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; iprodione inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; iprodione inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] iprodione binds to AR protein
CTD
PMID:19564212 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
EXP
iprodione results in decreased expression of BCL2 protein Chlorpyrifos promotes the reaction [iprodione results in decreased expression of BCL2 protein]; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]
CTD
PMID:33586219
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
increases expression multiple interactions
EXP
iprodione results in increased expression of CASP3 protein Chlorpyrifos promotes the reaction [iprodione results in increased expression of CASP3 protein]
CTD
PMID:33586219
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cldn11
claudin 11
increases expression multiple interactions
EXP
iprodione results in increased expression of CLDN11 protein [carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein
CTD
PMID:28576679
NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases activity
ISO
iprodione results in increased activity of CYP19A1 protein
CTD
PMID:11884232
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
iprodione results in increased expression of CYP1A1 mRNA; iprodione results in increased expression of CYP1A1 protein
CTD
PMID:16696176 PMID:32194361
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases expression
ISO
iprodione results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA
CTD
PMID:25028461
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
iprodione results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
iprodione results in increased expression of DDIT3 mRNA
CTD
PMID:16696176
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Esr1
estrogen receptor 1
multiple interactions
ISO
iprodione binds to and results in increased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
multiple interactions
ISO
iprodione binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
iprodione results in increased expression of FOS mRNA
CTD
PMID:16696176
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fshb
follicle stimulating hormone subunit beta
multiple interactions
EXP
iprodione promotes the reaction [Chlorpyrifos results in decreased expression of FSHB protein]
CTD
PMID:33586219
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
iprodione results in increased expression of GADD45A mRNA
CTD
PMID:16696176
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gja1
gap junction protein, alpha 1
multiple interactions
EXP
[carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein
CTD
PMID:28576679
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Gsta2
glutathione S-transferase alpha 2
increases expression
ISO
iprodione results in increased expression of GSTA2 mRNA
CTD
PMID:16696176
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
G
H2ax
H2A.X variant histone
multiple interactions
ISO
[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein
CTD
PMID:22389207
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
G
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
multiple interactions
EXP
[iprodione co-treated with Chlorpyrifos] results in decreased expression of HSD17B3 mRNA
CTD
PMID:33586219
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
iprodione results in increased expression of HSPA5 mRNA
CTD
PMID:16696176
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; iprodione binds to and results in increased activity of NR1I2 protein
CTD
PMID:25028461 PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr5a1
nuclear receptor subfamily 5, group A, member 1
decreases expression multiple interactions
EXP
iprodione results in decreased expression of NR5A1 mRNA iprodione promotes the reaction [Chlorpyrifos results in decreased expression of NR5A1 mRNA]
CTD
PMID:33586219
NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
G
Pparg
peroxisome proliferator-activated receptor gamma
increases activity multiple interactions
ISO
iprodione results in increased activity of PPARG protein iprodione binds to and results in increased activity of PPARG protein
CTD
PMID:20143881 PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppargc1a
PPARG coactivator 1 alpha
decreases expression multiple interactions
EXP
iprodione results in decreased expression of PPARGC1A mRNA Chlorpyrifos promotes the reaction [iprodione results in decreased expression of PPARGC1A mRNA]; iprodione promotes the reaction [Chlorpyrifos results in decreased expression of PPARGC1A mRNA]
CTD
PMID:33586219
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
G
Sirt1
sirtuin 1
multiple interactions decreases expression
EXP
[iprodione co-treated with Chlorpyrifos] results in decreased expression of SIRT1 mRNA iprodione results in decreased expression of SIRT1 mRNA
CTD
PMID:33586219
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
G
Stmn1
stathmin 1
increases expression
EXP
iprodione results in increased expression of STMN1 mRNA
CTD
PMID:28576679
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
G
Tert
telomerase reverse transcriptase
multiple interactions decreases expression
EXP
[iprodione co-treated with Chlorpyrifos] results in decreased expression of TERT mRNA iprodione results in decreased expression of TERT mRNA
CTD
PMID:33586219
NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
iprodione binds to and results in increased activity of THRA protein
CTD
PMID:33049310
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Thrb
thyroid hormone receptor beta
multiple interactions
ISO
iprodione binds to and results in increased activity of THRB protein
CTD
PMID:33049310
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Tnf
tumor necrosis factor
multiple interactions
ISO
Acetylcysteine inhibits the reaction [iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD
PMID:33226166
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all