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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iprodione
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Accession:CHEBI:28909 term browser browse the term
Definition:An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide.
Synonyms:exact_synonym: 3-(3,5-dichlorophenyl)-2,4-dioxo-N-(propan-2-yl)-imidazolidine-1-carboxamide
 related_synonym: 3-(3,5-dichlorophenyl)-1-(1-methylethyl)carbamoylhydantoin;   3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide;   3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxoimidazolidine-1-carboxamide;   3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide;   3-(3,5-dichlorophenyl)hydantoin-1-carboxylic acid isopropylamide;   Formula=C13H13Cl2N3O3;   InChI=1S/C13H13Cl2N3O3/c1-7(2)16-12(20)17-6-11(19)18(13(17)21)10-4-8(14)3-9(15)5-10/h3-5,7H,6H2,1-2H3,(H,16,20);   InChIKey=ONUFESLQCSAYKA-UHFFFAOYSA-N;   Rovral;   Rovrol;   SMILES=CC(C)NC(=O)N1CC(=O)N(C1=O)c1cc(Cl)cc(Cl)c1
 alt_id: CHEBI:24871;   CHEBI:8902
 xref: Beilstein:895003;   CAS:36734-19-7;   HMDB:HMDB0031795;   KEGG:C11208
 xref_mesh: MESH:C033148
 xref: PMID:11451425;   PMID:22115616;   PMID:22262495;   PPDB:403;   Patent:CN103053579;   Patent:CN103392726;   Patent:DE2149923;   Patent:US3755350;   Pesticides:iprodione;   Reaxys:895003;   UM-BBD_compID:c0635;   Wikipedia:Iprodione

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iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO
EXP		 iprodione binds to and results in increased activity of AHR protein CTD PMID:14636698 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Anxa10 annexin A10 increases expression ISO iprodione results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:29,674,699...29,741,521
Ensembl chr16:29,674,793...29,741,465 		JBrowse link
G Ar androgen receptor multiple interactions
affects binding		 ISO [iprodione binds to and results in decreased activity of AR protein] inhibits the reaction [Metribolone binds to AR protein]; iprodione inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; iprodione inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
iprodione binds to AR protein		 CTD PMID:19564212 PMID:33049310 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cldn11 claudin 11 increases expression
multiple interactions		 EXP iprodione results in increased expression of CLDN11 protein
[carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein		 CTD PMID:28576679 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity ISO iprodione results in increased activity of CYP19A1 protein CTD PMID:11884232 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO iprodione results in increased expression of CYP1A1 mRNA; iprodione results in increased expression of CYP1A1 protein CTD PMID:16696176 PMID:32194361 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO iprodione results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO iprodione results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO iprodione results in increased expression of DDIT3 mRNA CTD PMID:16696176 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO iprodione binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO iprodione binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO iprodione results in increased expression of FOS mRNA CTD PMID:16696176 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO iprodione results in increased expression of GADD45A mRNA CTD PMID:16696176 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO iprodione results in increased expression of GSTA2 mRNA CTD PMID:16696176 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein CTD PMID:22389207 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO iprodione results in increased expression of HSPA5 mRNA CTD PMID:16696176 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased activity of NR1I2 protein; iprodione binds to and results in increased activity of NR1I2 protein CTD PMID:25028461 PMID:33049310 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions		 ISO iprodione results in increased activity of PPARG protein
iprodione binds to and results in increased activity of PPARG protein		 CTD PMID:20143881 PMID:33049310 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Stmn1 stathmin 1 increases expression EXP iprodione results in increased expression of STMN1 mRNA CTD PMID:28576679 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO iprodione binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO iprodione binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Acetylcysteine inhibits the reaction [iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; iprodione inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:33226166 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        pesticide 16670
          nematicide 3538
            iprodione 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic acid 18215
                                        carboacyl group 17441
                                          univalent carboacyl group 17441
                                            carbamoyl group 17248
                                              carboxamide 17248
                                                monocarboxylic acid amide 14868
                                                  urea 5107
                                                    ureas 5105
                                                      iprodione 23
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