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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perchlorate
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Accession:CHEBI:49706 term browser browse the term
Definition:A monovalent inorganic anion obtained by deprotonation of perchloric acid.
Synonyms:exact_synonym: tetraoxidochlorate(1-)
 related_synonym: Chlorat(VII);   ClO4(-);   Formula=ClO4;   InChI=1S/ClHO4/c2-1(3,4)5/h(H,2,3,4,5)/p-1;   InChIKey=VLTRZXGMWDSKGL-UHFFFAOYSA-M;   PERCHLORATE ION;   Perchlorat;   SMILES=[O-]Cl(=O)(=O)=O;   tetraoxochlorate;   tetraoxochlorate(1-);   tetraoxochlorate(VII)
 alt_id: CHEBI:29220;   CHEBI:49705;   MESH:C494474
 xref: CAS:14797-73-0;   DrugBank:DB03138;   Gmelin:2136
 xref_mesh: MESH:C494474
 xref: MolBase:1883;   PDBeChem:LCP
 cyclic_relationship: is_conjugate_base_of CHEBI:29221


show annotations for term's descendants           Sort by:
perchlorate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp1 aquaporin 1 affects expression EXP perchlorate affects the expression of AQP1 mRNA CTD PMID:21623536 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression EXP perchlorate results in decreased expression of BDNF mRNA CTD PMID:35385113 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bmp7 bone morphogenetic protein 7 decreases expression EXP perchlorate results in decreased expression of BMP7 mRNA CTD PMID:35385113 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression EXP perchlorate results in decreased expression of CAMK4 mRNA CTD PMID:35385113 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO perchlorate results in decreased activity of CA1 protein CTD PMID:15664814 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO perchlorate results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car5a carbonic anhydrase 5A decreases activity ISO perchlorate results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906 		JBrowse link
G Car9 carbonic anhydrase 9 decreases activity ISO perchlorate results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP perchlorate results in increased activity of CASP3 protein
Sodium Iodide promotes the reaction [perchlorate results in increased activity of CASP3 protein]		 CTD PMID:11834455 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [sodium perchlorate results in increased abundance of perchlorate] which results in increased expression of FOS protein CTD PMID:30991129 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Mir133a1 microRNA 133a-1 multiple interactions ISO [Methimazole co-treated with perchlorate] results in increased expression of MIR133A1 mRNA CTD PMID:20808432 NCBI chr18:1,885,082...1,885,168 JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Methimazole co-treated with perchlorate] results in increased expression of MIR133B mRNA CTD PMID:20808432 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217 		JBrowse link
G Mir135a microRNA 135a multiple interactions ISO [Methimazole co-treated with perchlorate] results in increased expression of MIR135A mRNA CTD PMID:20808432 NCBI chr 7:26,611,990...26,612,089
Ensembl chr 7:26,611,990...26,612,089 		JBrowse link
G Mir135b microRNA 135b multiple interactions ISO [Methimazole co-treated with perchlorate] results in increased expression of MIR135B mRNA CTD PMID:20808432 NCBI chr13:43,638,857...43,638,953
Ensembl chr13:43,638,857...43,638,953 		JBrowse link
G Mir148a microRNA 148a multiple interactions ISO [Methimazole co-treated with perchlorate] results in decreased expression of MIR148A mRNA CTD PMID:20808432 NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858 		JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Methimazole co-treated with perchlorate] results in increased expression of MIR206 mRNA CTD PMID:20808432 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions ISO perchlorate binds to and results in decreased activity of PAPSS1 protein CTD PMID:15065880 NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395 		JBrowse link
G Pax8 paired box 8 decreases expression EXP perchlorate results in decreased expression of PAX8 mRNA CTD PMID:35385113 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 affects expression EXP perchlorate affects the expression of SLC22A3 mRNA CTD PMID:21623536 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc26a4 solute carrier family 26 member 4 increases expression EXP perchlorate results in increased expression of SLC26A4 mRNA CTD PMID:35385113 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 increases expression
multiple interactions
decreases activity
affects expression		 ISO
EXP		 perchlorate results in increased expression of SLC5A5 protein
perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]]; perchlorate inhibits the reaction [SLC5A5 protein results in increased abundance of Sodium Iodide]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]
perchlorate results in decreased activity of SLC5A5 protein
perchlorate affects the expression of SLC5A5 mRNA
perchlorate results in increased expression of SLC5A5 mRNA		 CTD PMID:12601449 PMID:14633711 PMID:15347726 PMID:15850642 PMID:15941870 More... NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Tg thyroglobulin decreases expression ISO
EXP		 perchlorate results in decreased expression of TG protein
perchlorate results in decreased expression of TG mRNA		 CTD PMID:17332529 PMID:35385113 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP perchlorate results in decreased expression of THRB mRNA CTD PMID:35385113 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tpo thyroid peroxidase increases expression EXP perchlorate results in increased expression of TPO mRNA CTD PMID:35385113 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression
multiple interactions		 ISO perchlorate results in increased expression of TSHB protein
[Iodides deficiency co-treated with perchlorate] results in increased expression of TSHB protein		 CTD PMID:17332529 PMID:20439182 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Tshr thyroid stimulating hormone receptor decreases expression EXP perchlorate results in decreased expression of TSHR mRNA CTD PMID:35385113 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538 		JBrowse link
sodium perchlorate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH1L1 protein CTD PMID:30090431 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH5A1 protein CTD PMID:30090431 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide increases expression EXP sodium perchlorate results in increased expression of CGA mRNA; sodium perchlorate results in increased expression of CGA protein CTD PMID:29139221 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of CTH protein CTD PMID:30090431 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of CYB5A protein CTD PMID:30090431 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases expression EXP sodium perchlorate results in decreased expression of DIO1 mRNA CTD PMID:29139221 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [sodium perchlorate results in increased abundance of perchlorate] which results in increased expression of FOS protein CTD PMID:30991129 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of FTCD protein CTD PMID:30090431 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of GAMT protein CTD PMID:30090431 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Ifng interferon gamma increases expression
multiple interactions		 EXP sodium perchlorate results in increased expression of IFNG mRNA
sodium perchlorate results in increased expression of and results in increased secretion of IFNG protein		 CTD PMID:29139221 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP sodium perchlorate results in increased expression of IL1A mRNA CTD PMID:29139221 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 EXP sodium perchlorate results in increased expression of and results in increased secretion of IL6 protein
sodium perchlorate results in increased expression of IL6 mRNA		 CTD PMID:29139221 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Krt18 keratin 18 multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of KRT18 protein CTD PMID:30090431 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lep leptin multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Iodine deficiency co-treated with sodium perchlorate] results in decreased secretion of LHB protein CTD PMID:30090431 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nkx2-1 NK2 homeobox 1 increases expression EXP sodium perchlorate results in increased expression of NKX2-1 protein CTD PMID:29139221 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Pax8 paired box 8 increases expression EXP sodium perchlorate results in increased expression of PAX8 protein CTD PMID:29139221 NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON1 protein; [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of PON1 protein CTD PMID:30090431 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon2 paraoxonase 2 multiple interactions EXP [[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON2 protein CTD PMID:30090431 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions
increases expression
decreases activity		 ISO
EXP		 sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Technetium]
sodium perchlorate results in increased expression of SLC5A5 mRNA; sodium perchlorate results in increased expression of SLC5A5 protein
sodium perchlorate results in decreased activity of SLC5A5 protein		 CTD PMID:12488351 PMID:12489024 PMID:12541134 PMID:15221289 PMID:15520214 More... NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Tg thyroglobulin increases expression EXP sodium perchlorate results in increased expression of TG protein CTD PMID:29139221 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 EXP sodium perchlorate results in increased expression of TNF mRNA
sodium perchlorate results in increased expression of and results in increased secretion of TNF protein		 CTD PMID:29139221 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpo thyroid peroxidase decreases activity
increases expression		 EXP sodium perchlorate results in decreased activity of TPO protein
sodium perchlorate results in increased expression of TPO mRNA; sodium perchlorate results in increased expression of TPO protein		 CTD PMID:23959146 PMID:29139221 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Trh thyrotropin releasing hormone decreases expression
increases expression		 EXP sodium perchlorate results in decreased expression of TRH protein
sodium perchlorate results in increased expression of TRH mRNA		 CTD PMID:29139221 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
increases expression		 ISO
EXP		 sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]]
[Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of TSHB protein
sodium perchlorate results in increased expression of TSHB mRNA; sodium perchlorate results in increased expression of TSHB protein		 CTD PMID:16030158 PMID:29139221 PMID:30090431 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Tshr thyroid stimulating hormone receptor increases expression EXP sodium perchlorate results in increased expression of TSHR mRNA; sodium perchlorate results in increased expression of TSHR protein CTD PMID:29139221 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      molecular entity 19806
        ion 16690
          anion 16074
            inorganic anion 12647
              monovalent inorganic anion 9451
                perchlorate 45
                  Magnesium perchlorate 0
                  sodium perchlorate 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            oxide 12745
                              oxoanion 10291
                                halogen oxoanion 236
                                  chlorine oxoanion 69
                                    perchlorate 45
                                      Magnesium perchlorate 0
                                      sodium perchlorate 26
paths to the root