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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:emamectin
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Accession:CHEBI:39230 term browser browse the term
Definition:A mixture of emamectin B1a (major component) and emamectin B1b (minor component).
Synonyms:related_synonym: (4''R)- 4''-deoxy-4''-(methylamino)avermectin B1;   4''-epi-methylamino-4''-deoxyavermectin B1
 xref: CAS:119791-41-2;   CAS:137335-79-6
 xref_mesh: MESH:C443359


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emamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions		 ISO emamectin results in decreased activity of ABCB1 protein
emamectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
emamectin results in decreased activity of ABCB1A protein
emamectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]		 CTD PMID:25865432 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity		 ISO emamectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
emamectin results in decreased activity of ABCC1 protein		 CTD PMID:25865432 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO emamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; emamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; emamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
emamectin benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity		 ISO Plant Oils inhibits the reaction [emamectin benzoate results in decreased activity of CAT protein] CTD PMID:29268245 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO emamectin benzoate results in increased expression of CCL11 mRNA CTD PMID:36269090 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression ISO emamectin benzoate results in increased expression of CCL27 mRNA CTD PMID:36269090 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression		 ISO Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of CYP2E1 mRNA] CTD PMID:29268245 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO emamectin benzoate results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions EXP [cypermethrin co-treated with emamectin benzoate] results in decreased expression of ESR1 mRNA; [cypermethrin co-treated with emamectin benzoate] results in decreased expression of ESR1 protein CTD PMID:37984602 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP [cypermethrin co-treated with emamectin benzoate] results in increased expression of FSHB protein CTD PMID:37984602 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP [cypermethrin co-treated with emamectin benzoate] results in decreased expression of GNRH1 protein CTD PMID:37984602 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP [cypermethrin co-treated with emamectin benzoate] results in decreased activity of GPX1 protein CTD PMID:37984602 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO emamectin benzoate results in increased expression of and affects the localization of IKBKB protein CTD PMID:36269090 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 decreases expression ISO emamectin benzoate results in decreased expression of IL10 mRNA CTD PMID:36269090 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 decreases expression ISO emamectin benzoate results in decreased expression of IL13 mRNA CTD PMID:36269090 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO emamectin benzoate results in increased expression of IL1B mRNA CTD PMID:36269090 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 increases expression ISO emamectin benzoate results in increased expression of IL2 mRNA CTD PMID:36269090 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il3 interleukin 3 increases expression ISO emamectin benzoate results in increased expression of IL3 mRNA CTD PMID:36269090 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 decreases expression ISO emamectin benzoate results in decreased expression of IL4 mRNA CTD PMID:36269090 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 increases expression ISO emamectin benzoate results in increased expression of IL5 mRNA CTD PMID:36269090 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases expression ISO emamectin benzoate results in increased expression of IL6 mRNA CTD PMID:36269090 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7 interleukin 7 increases expression ISO emamectin benzoate results in increased expression of IL7 mRNA CTD PMID:36269090 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Il9 interleukin 9 increases expression ISO emamectin benzoate results in increased expression of IL9 mRNA CTD PMID:36269090 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor multiple interactions EXP [cypermethrin co-treated with emamectin benzoate] results in increased expression of KISS1 mRNA; [cypermethrin co-treated with emamectin benzoate] results in increased expression of KISS1 protein CTD PMID:37984602 NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612 		JBrowse link
G Kiss1r KISS1 receptor multiple interactions EXP [cypermethrin co-treated with emamectin benzoate] results in increased expression of KISS1R mRNA; [cypermethrin co-treated with emamectin benzoate] results in increased expression of KISS1R protein CTD PMID:37984602 NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression
multiple interactions		 ISO emamectin benzoate results in increased expression of MGST1 mRNA
Plant Oils inhibits the reaction [emamectin benzoate results in increased expression of MGST1 mRNA]		 CTD PMID:29268245 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO emamectin benzoate results in increased expression of MIF mRNA CTD PMID:36269090 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO emamectin benzoate results in increased expression of NFKBIA protein CTD PMID:36269090 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO emamectin benzoate results in decreased expression of NOS2 protein CTD PMID:36269090 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nts neurotensin affects activity ISO emamectin benzoate affects the activity of NTS protein CTD PMID:23611293 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO emamectin benzoate results in increased phosphorylation of RELA protein CTD PMID:36269090 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [cypermethrin co-treated with emamectin benzoate] results in decreased activity of SOD1 protein CTD PMID:37984602 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO emamectin benzoate results in increased expression of TNF mRNA CTD PMID:36269090 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        pesticide 17927
          insecticide 16518
            antibiotic insecticide 249
              macrolide insecticide 56
                avermectin insecticide 55
                  emamectin 34
                    emamectin benzoate 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            heteroorganic entity 19492
                              organochalcogen compound 19255
                                organooxygen compound 19172
                                  ester 17354
                                    carboxylic ester 16736
                                      lactone 13238
                                        macrocyclic lactone 7580
                                          macrolide 7528
                                            macrolide antibiotic 733
                                              macrolide pesticide 56
                                                macrolide insecticide 56
                                                  avermectin insecticide 55
                                                    emamectin 34
                                                      emamectin benzoate 30
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