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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:39230
Term: emamectin
Definition: A mixture of emamectin B1a (major component) and emamectin B1b (minor component).
Chemical ID: MESH:C443359
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4multiple interactionsISORGD:7341036480464CTDemamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]], emamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein], emamectin inhibits the reaction [pregna-4, 17-diene-3, 16-dione results in decreased activity of NR1H4 protein]

PMID:25257666, PMID:27773686
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.