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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:organofluorine pesticide
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Accession:CHEBI:38805 term browser browse the term
Synonyms:related_synonym: fluoroorganic pesticide;   fluororganische Pestizide;   organofluorine pesticides


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chlorfluazuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
increases activity		 ISO chlorfluazuron results in increased expression of CYP2B6 mRNA
chlorfluazuron results in increased activity of CYP2B6 protein		 CTD PMID:22310298 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO chlorfluazuron inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
chlorfluazuron results in decreased activity of CYP2E1 protein		 CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO chlorfluazuron results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
etoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 ISO etoxazole results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; U 0126 promotes the reaction [etoxazole results in increased phosphorylation of AKT1 protein]		 CTD PMID:33618463 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor increases expression ISO etoxazole results in increased expression of AR mRNA CTD PMID:33618463 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects expression
increases expression		 ISO etoxazole affects the expression of CYP17A1 mRNA
etoxazole results in increased expression of CYP17A1 mRNA		 CTD PMID:33618463 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO etoxazole results in increased expression of CYP3A4 mRNA CTD PMID:17293382 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO etoxazole results in increased expression of JUN mRNA CTD PMID:33618463 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO etoxazole results in decreased expression of JUND mRNA CTD PMID:33618463 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein] CTD PMID:33618463 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein] CTD PMID:33618463 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression
affects expression		 ISO etoxazole results in increased expression of STAR mRNA
etoxazole affects the expression of STAR mRNA		 CTD PMID:33618463 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
flubendiamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
multiple interactions		 EXP flubendiamide results in decreased activity of CAT protein
alpha-Tocopherol affects the reaction [flubendiamide results in decreased activity of CAT protein]		 CTD PMID:27823922 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO flubendiamide promotes the reaction [Ryanodine binds to RYR1 protein] CTD PMID:30329129 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
flucythrinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [flucythrinate results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects binding ISO flucythrinate binds to CYP3A4 protein CTD PMID:32278787 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO flucythrinate results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO flucythrinate binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO flucythrinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO flucythrinate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO flucythrinate binds to RORA protein CTD PMID:32278787 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Vdr vitamin D receptor affects binding ISO flucythrinate binds to VDR protein CTD PMID:32278787 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
fluensulfone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases response to substance
increases metabolic processing		 ISO CYP2F2 protein results in increased susceptibility to fluensulfone
CYP2F2 protein results in increased metabolism of fluensulfone		 CTD PMID:27605420 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
flumethrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO flumethrin results in increased expression of BAX mRNA CTD PMID:34142587 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO flumethrin results in decreased expression of BCL2 mRNA CTD PMID:34142587 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO flumethrin results in increased expression of CDKN1A mRNA CTD PMID:34142587 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO flumethrin results in increased expression of ESR1 mRNA CTD PMID:34142587 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO flumethrin results in increased expression of ESR2 mRNA CTD PMID:34142587 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Pgr progesterone receptor increases expression ISO flumethrin results in increased expression of PGR mRNA CTD PMID:34142587 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO flumethrin results in increased expression of TFF1 mRNA CTD PMID:34142587 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO flumethrin results in increased expression of TP53 mRNA CTD PMID:34142587 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
flupyradifurone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases transport		 ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of flupyradifurone] CTD PMID:37011773 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
fluvalinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO fluvalinate analog promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:25684042 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects binding ISO fluvalinate binds to CDK2 protein CTD PMID:32278787 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects binding ISO fluvalinate binds to CYP3A4 protein CTD PMID:32278787 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects binding ISO fluvalinate binds to ERBB2 protein CTD PMID:32278787 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects binding ISO fluvalinate binds to FGFR2 protein CTD PMID:32278787 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO fluvalinate binds to MMP9 protein CTD PMID:32278787 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects binding ISO fluvalinate binds to NQO1 protein CTD PMID:32278787 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO fluvalinate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding ISO fluvalinate binds to PPARD protein CTD PMID:32278787 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO fluvalinate binds to RORA protein CTD PMID:32278787 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Rorc RAR-related orphan receptor C affects binding ISO fluvalinate binds to RORC protein CTD PMID:32278787 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
hexaflumuron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases expression EXP hexafluoron results in decreased expression of ALB protein CTD PMID:34993831 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP hexafluoron results in increased expression of BAX mRNA CTD PMID:35773501 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP hexafluoron results in decreased expression of BCL2 mRNA CTD PMID:35773501 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression EXP hexafluoron results in increased expression of CASP3 mRNA; hexafluoron results in increased expression of CASP3 protein CTD PMID:34993831 PMID:35773501 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity EXP hexafluoron results in decreased activity of CAT protein CTD PMID:35773501 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity
increases expression		 ISO hexafluoron results in increased activity of CYP2B6 protein
hexafluoron results in increased expression of CYP2B6 mRNA		 CTD PMID:22310298 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO hexafluoron results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP hexafluoron results in increased expression of GPT protein CTD PMID:34993831 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP hexafluoron results in increased expression of HMOX1 mRNA CTD PMID:34993831 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP hexafluoron results in decreased expression of KEAP1 mRNA CTD PMID:34993831 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression EXP hexafluoron results in increased expression of MAPK8 mRNA CTD PMID:34993831 PMID:35773501 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP hexafluoron results in increased expression of TNF protein CTD PMID:34993831 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pesticide 18059
          organofluorine pesticide 42
            N-\{2-[(4,6-dimethoxypyrimidin-2-yl)(hydroxy)methyl]-6-(methoxymethyl)phenyl\}-1,1-difluoromethanesulfonamide + 0
            fluazaindolizine 0
            flucofuron 0
            fluensulfone 1
            fluoroimide 0
            inpyrfluxam 0
            isoflucypram 0
            organofluorine acaricide + 29
            organofluorine insecticide + 29
            pyraziflumid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organohalogen compound 18520
                                organofluorine compound 14990
                                  organofluorine pesticide 42
                                    N-\{2-[(4,6-dimethoxypyrimidin-2-yl)(hydroxy)methyl]-6-(methoxymethyl)phenyl\}-1,1-difluoromethanesulfonamide + 0
                                    fluazaindolizine 0
                                    flucofuron 0
                                    fluensulfone 1
                                    fluoroimide 0
                                    inpyrfluxam 0
                                    isoflucypram 0
                                    organofluorine acaricide + 29
                                    organofluorine insecticide + 29
                                    pyraziflumid 0
paths to the root