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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bacitracin A
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Accession:CHEBI:35862 term browser browse the term
Definition:A homodetic cyclic peptide consisting of (4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid attached head-to-tail to L-leucyl,D-glutamyl, L-lysyl, D-ornityl, L-isoleucyl, D-phenylalanyl, L-histidyl. D-aspartyl and L-asparaginyl residues coupled in sequence and cyclised by condensation of the side-chain amino group of the L-lysyl residue with the C-terminal carboxylic acid group. It is the major component of bacitracin.
Synonyms:exact_synonym: N-({(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazol-4-yl}carbonyl)-L-leucyl-D-alpha-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-4-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]-L-isoleucinamide
 related_synonym: Bacitracin A2a;   Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-l-leucine)-;   Formula=C66H103N17O16S;   InChI=1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35-,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48-,52-,53-,54-/m0/s1;   InChIKey=CLKOFPXJLQSYAH-ABRJDSQDSA-N;   SMILES=CC[C@H](C)[C@H](N)C1=N[C@@H](CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]1CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC1=O)[C@@H](C)CC
 xref: CAS:22601-59-8;   KEGG:C15482;   Reaxys:8969478


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bacitracin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Bacitracin results in increased expression of A2M mRNA CTD PMID:18289764 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Bacitracin binds to and results in decreased metabolism of and results in decreased secretion of ACHE protein CTD PMID:23047022 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Bacitracin results in increased expression of ALDH1A1 mRNA CTD PMID:18289764 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Anxa5 annexin A5 increases expression EXP Bacitracin results in increased expression of ANXA5 mRNA CTD PMID:18289764 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Bmp1 bone morphogenetic protein 1 increases expression EXP Bacitracin results in increased expression of BMP1 mRNA CTD PMID:18289764 NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776 		JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Bacitracin results in decreased expression of BMP4 mRNA CTD PMID:18289764 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Calb1 calbindin 1 decreases expression EXP Bacitracin results in decreased expression of CALB1 mRNA CTD PMID:18289764 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Cat catalase decreases expression EXP Bacitracin results in decreased expression of CAT mRNA CTD PMID:18289764 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn1 cellular communication network factor 1 affects expression EXP Bacitracin affects the expression of CCN1 mRNA CTD PMID:18289764 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Bacitracin results in increased expression of CCND1 mRNA CTD PMID:18289764 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP Bacitracin results in increased expression of CCNG1 mRNA CTD PMID:18289764 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cd24 CD24 molecule increases expression EXP Bacitracin results in increased expression of CD24 mRNA CTD PMID:18289764 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
G Cd44 CD44 molecule increases expression EXP Bacitracin results in increased expression of CD44 mRNA CTD PMID:18289764 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Clu clusterin increases expression EXP Bacitracin results in increased expression of CLU mRNA CTD PMID:18289764 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cp ceruloplasmin increases expression EXP Bacitracin results in increased expression of CP mRNA CTD PMID:18289764 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Ctss cathepsin S increases expression EXP Bacitracin results in increased expression of CTSS mRNA CTD PMID:18289764 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases expression EXP Bacitracin results in decreased expression of CYP2D22 mRNA CTD PMID:18289764 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Egf epidermal growth factor decreases expression EXP Bacitracin results in decreased expression of EGF mRNA CTD PMID:18289764 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fn1 fibronectin 1 increases expression EXP Bacitracin results in increased expression of FN1 mRNA CTD PMID:18289764 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Bacitracin results in decreased expression of G6PC1 mRNA CTD PMID:18289764 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Bacitracin results in increased expression of GADD45A mRNA CTD PMID:18289764 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Ghr growth hormone receptor affects expression EXP Bacitracin affects the expression of GHR mRNA CTD PMID:18289764 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735 		JBrowse link
G Glul glutamate-ammonia ligase increases expression EXP Bacitracin results in increased expression of GLUL mRNA CTD PMID:18289764 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Bacitracin results in increased expression of GSTM2 mRNA CTD PMID:18289764 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Bacitracin results in increased expression of HAVCR1 mRNA CTD PMID:18289764 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Bacitracin results in increased expression of HMOX1 mRNA CTD PMID:18289764 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 increases expression EXP Bacitracin results in increased expression of HMOX2 mRNA CTD PMID:18289764 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Bacitracin results in increased expression of IGFBP1 mRNA CTD PMID:18289764 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Igkc immunoglobulin kappa constant decreases expression
increases expression		 EXP Bacitracin results in decreased expression of IGKC mRNA
Bacitracin results in increased expression of IGKC mRNA		 CTD PMID:18289764
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Bacitracin results in increased expression of JUN mRNA CTD PMID:18289764 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klk1b3 kallikrein 1-related peptidase B3 decreases expression EXP Bacitracin results in decreased expression of KLK1B3 mRNA CTD PMID:18289764 NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Bacitracin results in increased expression of LCN2 mRNA CTD PMID:18289764 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Mgp matrix Gla protein increases expression EXP Bacitracin results in increased expression of MGP mRNA CTD PMID:18289764 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP Bacitracin results in increased expression of MT1A mRNA CTD PMID:18289764 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin decreases expression EXP Bacitracin results in decreased expression of NPHS2 mRNA CTD PMID:18289764 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Oat ornithine aminotransferase increases expression EXP Bacitracin results in increased expression of OAT mRNA CTD PMID:18289764 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Rgn regucalcin decreases expression EXP Bacitracin results in decreased expression of RGN mRNA CTD PMID:18289764 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression EXP Bacitracin results in decreased expression of SLC22A1 mRNA CTD PMID:18289764 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP Bacitracin results in decreased expression of SLC22A6 mRNA CTD PMID:18289764 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Bacitracin results in increased expression of SPP1 mRNA CTD PMID:18289764 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Bacitracin results in increased expression of TIMP1 mRNA CTD PMID:18289764 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tmsb10 thymosin, beta 10 increases expression EXP Bacitracin results in increased expression of TMSB10 mRNA CTD PMID:18289764 NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Bacitracin results in increased expression of VCAM1 mRNA CTD PMID:18289764 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Bacitracin results in decreased expression of VEGFA mRNA CTD PMID:18289764 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin increases expression EXP Bacitracin results in increased expression of VIM mRNA CTD PMID:18289764 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      biological role 19858
        antimicrobial agent 18239
          bacitracin A 45
            bacitracin 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbon oxoacid 18666
                                    carboxylic acid 18663
                                      carboacyl group 17715
                                        univalent carboacyl group 17690
                                          carbamoyl group 17566
                                            carboxamide 17566
                                              peptide 11439
                                                cyclic peptide 8924
                                                  homodetic cyclic peptide 8402
                                                    bacitracin A 45
                                                      bacitracin 45
paths to the root