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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bellidifolin
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Accession:CHEBI:3008 term browser browse the term
Definition:A member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris.
Synonyms:exact_synonym: 1,5,8-trihydroxy-3-methoxy-9H-xanthen-9-one
 related_synonym: 3-Methoxy-1,5,8-trihydroxyxanthone;   Bellidifoline;   Bellidifolium;   Formula=C14H10O6;   InChI=1S/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5,15-17H,1H3;   InChIKey=JDIORNFCMMYMLF-UHFFFAOYSA-N;   SMILES=COc1cc(O)c2c(c1)oc1c(O)ccc(O)c1c2=O
 alt_id: CHEBI:65477
 xref: CAS:2798-25-6;   CBA:344058;   KEGG:C10053;   KNApSAcK:C00002943
 xref_mesh: MESH:C091291
 xref: PMID:15490334;   PMID:18336006;   PMID:18446672;   PMID:19962285;   PMID:20614821;   PMID:21985644;   PMID:7480198;   PMID:7809201;   Reaxys:288441


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bellidifolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of ADAM17 mRNA] CTD PMID:37528096 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of AKT1 mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:36518482 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of BRD4 protein] CTD PMID:37528096 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein] CTD PMID:37127800 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases expression ISO bellidifolin results in increased expression of CASP3 protein CTD PMID:33299414 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression ISO bellidifolin results in increased expression of CASP8 protein CTD PMID:33299414 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO bellidifolin results in decreased expression of CEBPB mRNA CTD PMID:33299414 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Gck glucokinase decreases activity ISO bellidifolin results in decreased activity of GCK protein CTD PMID:19962285 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP bellidifolin results in increased expression of GCLC mRNA; bellidifolin results in increased expression of GCLC protein CTD PMID:30800665 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] affects the localization of GSDMD protein alternative form]; bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GSDMD protein] CTD PMID:37127800 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of GSK3B mRNA]; bellidifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of GSK3B protein] CTD PMID:36518482 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP bellidifolin results in increased expression of HMOX1 mRNA; bellidifolin results in increased expression of HMOX1 protein CTD PMID:30800665 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased secretion of IL18 protein] CTD PMID:37127800 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased secretion of IL1B protein] CTD PMID:37127800 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Insr insulin receptor increases expression ISO bellidifolin results in increased expression of INSR CTD PMID:19962285 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 increases expression ISO bellidifolin results in increased expression of IRS1 CTD PMID:19962285 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of MYH7 protein] CTD PMID:37528096 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein] CTD PMID:37127800 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA]; bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NOX4 protein] CTD PMID:37528096 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPA protein] CTD PMID:37528096 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:37528096 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of NR4A1 protein] CTD PMID:33995055 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO bellidifolin results in decreased expression of PARP1 protein CTD PMID:33299414 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ptger2 prostaglandin E receptor 2 decreases expression ISO bellidifolin results in decreased expression of PTGER2 mRNA CTD PMID:33299414 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO bellidifolin results in decreased expression of PTGER4 mRNA CTD PMID:33299414 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO bellidifolin results in decreased expression of PTGS2 protein CTD PMID:33299414 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO bellidifolin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PYCARD protein] CTD PMID:37127800 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of SMAD2 protein] CTD PMID:33995055 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:33995055 PMID:35586685 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein] CTD PMID:33995055 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions ISO bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SOX9 protein]
bellidifolin inhibits the reaction [Isoproterenol results in increased expression of SOX9 protein]		 CTD PMID:35586685 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression		 ISO bellidifolin results in decreased expression of and results in decreased phosphorylation of STAT3 protein
bellidifolin results in decreased expression of STAT3 mRNA		 CTD PMID:33299414 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SOX9 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of SMAD2 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR1 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR2 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of SMAD4 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of and affects the localization of NR4A1 protein]; bellidifolin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]		 CTD PMID:33995055 PMID:35586685 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR1 protein] CTD PMID:33995055 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions EXP bellidifolin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased phosphorylation of TGFBR2 protein] CTD PMID:33995055 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 bellidifolin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA] CTD PMID:37528096 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        biochemical role 19589
          metabolite 19575
            bellidifolin 36
              swerchirin 0
              swertianolin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19794
                        carbon atom 19790
                          organic molecular entity 19790
                            organic molecule 19743
                              organic cyclic compound 19533
                                organic heterocyclic compound 18900
                                  oxacycle 17920
                                    dibenzopyran 280
                                      xanthenes 274
                                        xanthones 210
                                          xanthone 185
                                            bellidin 36
                                              bellidifolin 36
                                                swerchirin 0
                                                swertianolin + 0
paths to the root