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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xanthone
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Accession:CHEBI:37647 term browser browse the term
Definition:The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.
Synonyms:exact_synonym: 9H-xanthen-9-one
 related_synonym: 9-oxoxanthene;   9-xanthenone;   9-xanthone;   Formula=C13H8O2;   Genicide;   InChI=1S/C13H8O2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H;   InChIKey=JNELGWHKGNBSMD-UHFFFAOYSA-N;   SMILES=O=c1c2ccccc2oc2ccccc12;   benzophenone oxide;   dibenzo-gamma-pyrone;   diphenylene ketone oxide;   xanthenone
 xref: Beilstein:140443;   CAS:90-47-1;   Gmelin:166003
 xref_mesh: MESH:C009689
 xref: Reaxys:140443;   Wikipedia:Xanthone


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xanthone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Lep leptin multiple interactions EXP xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
mangiferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 ISO mangiferin results in increased expression of ABCB1 mRNA; mangiferin results in increased expression of ABCB1 protein
Dichlororibofuranosylbenzimidazole inhibits the reaction [mangiferin results in increased expression of ABCB1 protein]		 CTD PMID:20513373 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases expression ISO mangiferin results in decreased expression of ABL1 mRNA CTD PMID:15498116 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases phosphorylation		 EXP dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of ACACA protein] CTD PMID:22292039 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein]
mangiferin results in decreased activity of ACHE protein		 CTD PMID:19182383 PMID:22426032 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:20683903 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADRB3 protein CTD PMID:32417366 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP mangiferin results in decreased expression of AGER mRNA; mangiferin results in decreased expression of AGER protein CTD PMID:24036348 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen multiple interactions EXP mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein] CTD PMID:17645561 PMID:19706694 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein] CTD PMID:17645561 PMID:19706694 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein] CTD PMID:19201465 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO		 mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased phosphorylation of AKT1 protein]
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]		 CTD PMID:19201465 PMID:22465218 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin affects binding ISO mangiferin binds to ALB protein CTD PMID:19157745 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein] CTD PMID:23451106 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] CTD PMID:20683903 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]
mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein]		 CTD PMID:19201465 PMID:23451106 PMID:24095822 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
mangiferin inhibits the reaction [Galactosamine results in decreased expression of BCL2 protein]
mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]		 CTD PMID:21420233 PMID:22118634 PMID:23451106 PMID:24095822 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO mangiferin results in decreased expression of BCL2L1 protein CTD PMID:21547680 PMID:26996543 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO mangiferin results in decreased expression of BIRC5 protein CTD PMID:26996543 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G C3 complement C3 decreases expression ISO mangiferin results in decreased expression of C3 mRNA CTD PMID:15135318 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Calcr calcitonin receptor multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:20683903 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]
mangiferin results in increased activity of CASP3 protein
mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP3 protein]		 CTD PMID:21547680 PMID:22118634 PMID:22310181 PMID:23451106 PMID:26996543 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression ISO mangiferin results in increased expression of CASP8 protein CTD PMID:32420661 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP		 mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein]
mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP9 protein]		 CTD PMID:22118634 PMID:23451106 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
increases activity		 ISO
EXP		 mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CAT mRNA]; mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
mangiferin inhibits the reaction [Mercuric Chloride results in decreased expression of CAT protein]
mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
mangiferin results in increased activity of CAT protein		 CTD PMID:15161907 PMID:16076520 PMID:16584858 PMID:16697266 PMID:17433543 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO mangiferin results in decreased expression of CCL2 mRNA CTD PMID:15135318 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein] CTD PMID:15135318 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO mangiferin results in increased expression of CCNB1 mRNA CTD PMID:20518311 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 EXP dorsomorphin inhibits the reaction [mangiferin results in increased expression of CD36 protein] CTD PMID:22292039 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdh1 cadherin 1 increases expression
affects expression
multiple interactions		 ISO mangiferin results in increased expression of CDH1 protein
mangiferin affects the expression of CDH1 protein
lipopolysaccharide, Escherichia coli O111 B4 affects the reaction [mangiferin affects the expression of CDH1 protein]		 CTD PMID:23707762 PMID:32420661 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO mangiferin results in increased expression of CDK1 mRNA CTD PMID:20518311 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]
mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of CHUK protein]		 CTD PMID:21420233 PMID:22310181 PMID:23451106 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CIDEA mRNA CTD PMID:32417366 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA] CTD PMID:19706694 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA] CTD PMID:19706694 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression
multiple interactions		 EXP mangiferin results in increased expression of CPT1A protein
dorsomorphin inhibits the reaction [mangiferin results in increased expression of CPT1A protein]		 CTD PMID:22292039 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases expression		 ISO mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein]
mangiferin results in decreased expression of CSF2 mRNA		 CTD PMID:15135318 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions
decreases expression		 ISO mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein]
mangiferin results in decreased expression of CSF3 mRNA		 CTD PMID:15135318 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ctnnb1 catenin beta 1 decreases response to substance ISO CTNNB1 protein results in decreased susceptibility to mangiferin CTD PMID:23707762 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctnnd1 catenin delta 1 multiple interactions ISO mangiferin inhibits the reaction [Paraquat results in decreased expression of and affects the localization of CTNND1 protein]; mangiferin inhibits the reaction [Paraquat results in decreased expression of CTNND1 mRNA alternative form] CTD PMID:24912632 NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516 		JBrowse link
G Ctsd cathepsin D multiple interactions EXP mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] CTD PMID:19172585 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:20683903 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CXCR4 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA] CTD PMID:21420233 PMID:32420661 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO mangiferin results in increased expression of CYP1A1 mRNA CTD PMID:22815239 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression		 EXP
ISO		 mangiferin results in decreased activity of CYP1A2 protein
mangiferin results in increased expression of CYP1A2 mRNA		 CTD PMID:18053976 PMID:22815239 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP mangiferin results in increased activity of CYP2B1 protein CTD PMID:18053976 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity EXP mangiferin results in decreased activity of CYP2C6V1 protein CTD PMID:18053976 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO mangiferin results in decreased activity of CYP2D6 protein CTD PMID:22815239 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP mangiferin results in decreased activity of CYP2E1 protein CTD PMID:18053976 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO mangiferin results in decreased activity of CYP3A4 protein CTD PMID:22815239 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases activity EXP mangiferin results in decreased activity of CYP3A23-3A1 protein CTD PMID:18053976 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:20683903 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression
affects expression
multiple interactions		 EXP mangiferin results in decreased expression of DGAT2 protein
mangiferin affects the expression of DGAT2 mRNA; mangiferin affects the expression of DGAT2 protein
dorsomorphin inhibits the reaction [mangiferin results in increased expression of DGAT2 protein]		 CTD PMID:22292039 PMID:25123789 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO mangiferin inhibits the reaction [Methylmercury Compounds results in increased expression of and results in increased phosphorylation of DNM1L protein] CTD PMID:28071871 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G F10 coagulation factor X decreases activity ISO mangiferin analog results in decreased activity of F10 protein CTD PMID:21732671 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO mangiferin results in increased expression of FAS protein CTD PMID:17634039 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO mangiferin results in decreased expression of FBP1 mRNA CTD PMID:19028559 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:19706694 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gcg glucagon multiple interactions EXP [mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of GCG protein alternative form CTD PMID:22948814 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Glo1 glyoxalase 1 increases expression
multiple interactions		 EXP mangiferin results in increased expression of GLO1 mRNA
mangiferin results in increased expression of and results in increased activity of GLO1 protein		 CTD PMID:24036348 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP mangiferin inhibits the reaction [Streptozocin results in increased activity of GPT protein] CTD PMID:29223569 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP		 mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]
mangiferin inhibits the reaction [Methylmercury Compounds results in decreased activity of GSR protein]
mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]		 CTD PMID:16697266 PMID:18816296 PMID:23451106 PMID:28071871 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein] CTD PMID:19172585 NCBI chr12:26,701,191...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP mangiferin inhibits the reaction [Galactosamine results in decreased expression of HMOX1 protein] CTD PMID:22310181 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
mangiferin results in decreased expression of ICAM1 mRNA		 CTD PMID:15135318 PMID:15161907 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Icam2 intercellular adhesion molecule 2 decreases expression ISO mangiferin results in decreased expression of ICAM2 mRNA CTD PMID:15135318 NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293 		JBrowse link
G Icam5 intercellular adhesion molecule 5 decreases expression ISO mangiferin results in decreased expression of ICAM5 mRNA CTD PMID:15135318 NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588 		JBrowse link
G Ifna1 interferon, alpha 1 increases expression ISO mangiferin results in increased expression of IFNA1 mRNA CTD PMID:15135318 NCBI chr 5:103,095,767...103,098,260
Ensembl chr 5:103,097,356...103,097,925 		JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO mangiferin results in increased expression of IFNB1 mRNA CTD PMID:15135318 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of IFNG mRNA]		 CTD PMID:12694877 PMID:15135318 PMID:15177302 PMID:15177305 PMID:15222974 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]
mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of IKBKB protein]		 CTD PMID:21420233 PMID:22310181 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP mangiferin inhibits the reaction [Galactosamine results in decreased expression of IL10 mRNA] CTD PMID:22310181 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A decreases expression ISO mangiferin results in decreased expression of IL12A mRNA CTD PMID:15135318 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions EXP mangiferin inhibits the reaction [Galactosamine results in increased expression of IL12B mRNA] CTD PMID:22310181 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] CTD PMID:22310181 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO mangiferin results in decreased expression of IL1A mRNA CTD PMID:15135318 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 mangiferin inhibits the reaction [Galactosamine results in increased expression of IL1B mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:15381052 PMID:22310181 PMID:27125760 PMID:27474068 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta decreases expression ISO mangiferin results in decreased expression of IL2RB mRNA CTD PMID:15135318 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 mangiferin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
mangiferin inhibits the reaction [Galactosamine results in increased expression of IL6 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [Ketamine results in increased expression of IL6 protein]
mangiferin results in decreased expression of IL6 mRNA		 CTD PMID:15135318 PMID:21420233 PMID:22310181 PMID:23087136 PMID:27474068 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf1 interferon regulatory factor 1 decreases expression ISO mangiferin results in decreased expression of IRF1 mRNA CTD PMID:15135318 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases activity
increases expression		 ISO MK-886 inhibits the reaction [mangiferin results in increased activity of LPL protein]; MK-886 inhibits the reaction [mangiferin results in increased expression of LPL mRNA] CTD PMID:15975614 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 decreases phosphorylation ISO mangiferin results in decreased phosphorylation of MAP3K14 protein CTD PMID:26996543 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
decreases activity
affects binding
multiple interactions		 ISO
EXP		 mangiferin results in increased phosphorylation of MAPK1 protein
mangiferin metabolite results in decreased activity of MAPK1 protein
mangiferin metabolite binds to MAPK1 protein
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases activity
increases phosphorylation		 ISO
EXP		 mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
mangiferin metabolite results in decreased activity of MAPK3 protein
mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein]
mangiferin results in increased phosphorylation of MAPK3 protein		 CTD PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression ISO mangiferin results in decreased expression of MAPK8 mRNA CTD PMID:15135318 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression ISO mangiferin results in decreased expression of MAPK9 mRNA CTD PMID:15135318 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Max MYC associated factor X decreases expression ISO mangiferin results in decreased expression of MAX mRNA CTD PMID:15135318 NCBI chr 6:95,636,857...95,662,204
Ensembl chr 6:95,636,858...95,662,137 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO mangiferin results in decreased expression of MMP7 protein CTD PMID:23707762 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
decreases activity		 ISO mangiferin results in decreased expression of MMP9 mRNA; mangiferin results in decreased expression of MMP9 protein
mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]
mangiferin results in decreased expression of and results in decreased secretion of MMP9 protein
mangiferin results in decreased activity of MMP9 protein		 CTD PMID:22465218 PMID:23707762 PMID:27125760 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO mangiferin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:27125760 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP mangiferin affects the reaction [Galactosamine affects the localization of NFE2L2 protein]; mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFE2L2 protein] CTD PMID:22310181 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:15161907 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein]
mangiferin results in increased expression of NFKBIA protein
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]		 CTD PMID:15161907 PMID:20683903 PMID:22310181 PMID:23451106 PMID:27474068 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression
multiple interactions		 ISO mangiferin results in decreased expression of NFKBIB mRNA
mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]		 CTD PMID:15135318 PMID:21420233 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO mangiferin results in decreased expression of NFKBIE mRNA CTD PMID:15135318 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437 		JBrowse link
G Nfkbil1 NFKB inhibitor like 1 decreases expression ISO mangiferin results in decreased expression of NFKBIL1 mRNA CTD PMID:15135318 NCBI chr20:3,589,974...3,608,348
Ensembl chr20:3,590,642...3,605,616 		JBrowse link
G Ngf nerve growth factor increases secretion ISO mangiferin results in increased secretion of NGF protein CTD PMID:20303935 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of NLRP3 protein] CTD PMID:32420661 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO		 mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNFB protein] results in increased expression of NOS2 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]		 CTD PMID:12694877 PMID:15381052 PMID:22118634 PMID:22310181 PMID:27474068 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP mangiferin inhibits the reaction [Galactosamine results in decreased expression of NQO1 protein] CTD PMID:22310181 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Per1 period circadian regulator 1 affects expression
multiple interactions		 ISO mangiferin affects the expression of PER1 protein
mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of PER1 protein]		 CTD PMID:32420661 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases activity ISO mangiferin results in decreased activity of PLA2G2A protein CTD PMID:15177302 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] CTD PMID:19706694 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity		 ISO MK-886 inhibits the reaction [mangiferin results in increased activity of PPARA protein]
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARA mRNA		 CTD PMID:15975614 PMID:32417366 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO		 mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein		 CTD PMID:29223569 PMID:32417366 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A protein CTD PMID:32417366 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prdm16 PR/SET domain 16 multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 protein CTD PMID:32417366 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein CTD PMID:22292039 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
affects expression		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
mangiferin affects the expression of PTGS2 mRNA		 CTD PMID:15161907 PMID:15381052 PMID:18621015 PMID:19026997 PMID:21420233 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO mangiferin results in decreased expression of RAF1 mRNA CTD PMID:15135318 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
decreases expression
decreases localization		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]
mangiferin affects the localization of RELA protein
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [Galactosamine results in increased expression of RELA protein]
mangiferin results in decreased expression of RELA mRNA
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]; mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]
mangiferin results in decreased localization of RELA protein		 CTD PMID:15135318 PMID:15161907 PMID:19182383 PMID:19201465 PMID:20683903 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit decreases expression ISO mangiferin results in decreased expression of RELB mRNA CTD PMID:15135318 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 decreases expression ISO mangiferin results in decreased expression of RIPK1 mRNA CTD PMID:15135318 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Sele selectin E decreases expression ISO mangiferin results in decreased expression of SELE mRNA CTD PMID:15135318 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selplg selectin P ligand decreases expression ISO mangiferin results in decreased expression of SELPLG mRNA CTD PMID:15135318 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA] CTD PMID:19706694 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO mangiferin results in increased expression of SLC22A1 mRNA CTD PMID:21348301 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression ISO mangiferin results in decreased expression of SLC22A12 mRNA; mangiferin results in decreased expression of SLC22A12 protein CTD PMID:21348301 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression ISO mangiferin results in increased expression of SLC22A2 mRNA CTD PMID:21348301 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 increases expression ISO mangiferin results in increased expression of SLC22A4 mRNA CTD PMID:21348301 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO mangiferin results in increased expression of SLC22A5 mRNA CTD PMID:21348301 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases expression		 ISO
EXP		 2-chloro-5-nitrobenzanilide inhibits the reaction [mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]]; mangiferin affects the localization of and results in increased activity of SLC2A4 protein; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Glucose]
mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]
mangiferin results in increased expression of SLC2A4 mRNA		 CTD PMID:19477051 PMID:29223569 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO mangiferin results in decreased expression of SNAI1 protein CTD PMID:23707762 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO mangiferin results in decreased expression of SNAI2 protein CTD PMID:23707762 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA] CTD PMID:17433543 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases activity ISO mangiferin results in decreased activity of SRD5A2 protein CTD PMID:20823678 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Srf serum response factor decreases expression ISO mangiferin results in decreased expression of SRF mRNA CTD PMID:15135318 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 decreases expression ISO mangiferin results in decreased expression of TAB1 mRNA CTD PMID:15135318 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tbk1 TANK-binding kinase 1 decreases expression ISO mangiferin results in decreased expression of TBK1 mRNA CTD PMID:15135318 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO mangiferin results in decreased activity of TERT protein CTD PMID:17634039 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP		 mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]
mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; mangiferin inhibits the reaction [Streptozocin results in increased secretion of TGFB1 protein]		 CTD PMID:12694877 PMID:19706694 PMID:19960420 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr6 toll-like receptor 6 decreases expression ISO mangiferin results in decreased expression of TLR6 mRNA CTD PMID:15135318 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr7 toll-like receptor 7 decreases expression ISO mangiferin results in decreased expression of TLR7 mRNA CTD PMID:15135318 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr8 toll-like receptor 8 decreases expression ISO mangiferin results in decreased expression of TLR8 mRNA CTD PMID:15135318 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
G Tlr9 toll-like receptor 9 decreases expression ISO mangiferin results in decreased expression of TLR9 mRNA CTD PMID:15135318 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
affects expression
increases secretion		 ISO
EXP		 mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein]; mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
mangiferin results in decreased expression of TNF mRNA
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]
mangiferin affects the expression of TNF protein
mangiferin results in increased secretion of TNF protein		 CTD PMID:12694877 PMID:15135318 PMID:15161907 PMID:15177305 PMID:15222974 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A decreases expression ISO mangiferin results in decreased expression of TNFRSF11A mRNA CTD PMID:15135318 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:20683903 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP mangiferin inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein] CTD PMID:10657591 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tradd TNFRSF1A-associated via death domain decreases expression ISO mangiferin results in decreased expression of TRADD mRNA CTD PMID:15135318 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf6 TNF receptor associated factor 6 decreases expression ISO mangiferin results in decreased expression of TRAF6 mRNA CTD PMID:15135318 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions ISO [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP1 protein CTD PMID:32417366 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
decreases activity		 ISO mangiferin results in increased expression of UGT1A1 mRNA
mangiferin results in decreased activity of UGT1A1 protein		 CTD PMID:22815239 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO mangiferin results in increased expression of UGT1A9 mRNA CTD PMID:22815239 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity ISO mangiferin results in decreased activity of UGT2B7 protein CTD PMID:22815239 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Umod uromodulin affects expression ISO mangiferin affects the expression of UMOD protein CTD PMID:21348301 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO mangiferin results in decreased expression of VCAM1 mRNA CTD PMID:15135318 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] CTD PMID:21420233 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin decreases expression
multiple interactions		 ISO mangiferin results in decreased expression of VIM protein
mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of VIM protein]		 CTD PMID:23707762 PMID:32420661 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
decreases expression		 ISO mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]
mangiferin results in decreased expression of XIAP protein		 CTD PMID:21420233 PMID:21547680 PMID:26996543 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        pesticide 17231
          insecticide 15266
            xanthone 151
              bellidin + 0
              mangiferin 149
              vieillardixanthone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      ketone 17097
                                        cyclic ketone 15648
                                          xanthones 175
                                            xanthone 151
                                              bellidin + 0
                                              mangiferin 149
                                              vieillardixanthone 0
paths to the root