|
G |
Ace2 |
angiotensin I converting enzyme 2 |
multiple interactions |
EXP |
xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] |
CTD |
PMID:25205467 |
|
NCBI chr X:32,050,734...32,095,860
Ensembl chr X:32,049,931...32,096,016
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G |
Lep |
leptin |
multiple interactions |
EXP |
xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein]; xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] |
CTD |
PMID:25205467 |
|
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions |
ISO |
mangiferin results in increased expression of ABCB1 mRNA; mangiferin results in increased expression of ABCB1 protein Dichlororibofuranosylbenzimidazole inhibits the reaction [mangiferin results in increased expression of ABCB1 protein] |
CTD |
PMID:20513373 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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|
G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
decreases expression |
ISO |
mangiferin results in decreased expression of ABL1 mRNA |
CTD |
PMID:15498116 |
|
NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388 Ensembl chr 3:10,041,826...10,144,388
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|
G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions increases phosphorylation |
EXP |
dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of ACACA protein] |
CTD |
PMID:22292039 |
|
NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
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G |
Ache |
acetylcholinesterase |
multiple interactions decreases activity |
ISO |
mangiferin inhibits the reaction [Scopolamine results in decreased expression of ACHE protein] mangiferin results in decreased activity of ACHE protein |
CTD |
PMID:19182383 PMID:22426032 |
|
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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|
G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] |
CTD |
PMID:20683903 |
|
NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
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|
G |
Adrb3 |
adrenoceptor beta 3 |
multiple interactions |
ISO |
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ADRB3 protein |
CTD |
PMID:32417366 |
|
NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
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|
G |
Ager |
advanced glycosylation end product-specific receptor |
decreases expression |
EXP |
mangiferin results in decreased expression of AGER mRNA; mangiferin results in decreased expression of AGER protein |
CTD |
PMID:24036348 |
|
NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
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|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein]; mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein] |
CTD |
PMID:17645561 PMID:19706694 |
|
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
EXP |
mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of AGTR1A protein] |
CTD |
PMID:17645561 PMID:19706694 |
|
NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein] |
CTD |
PMID:19201465 |
|
NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP ISO |
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased phosphorylation of AKT1 protein] mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:19201465 PMID:22465218 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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|
G |
Alb |
albumin |
affects binding |
ISO |
mangiferin binds to ALB protein |
CTD |
PMID:19157745 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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|
G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO |
mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein] |
CTD |
PMID:23451106 |
|
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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|
G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA] |
CTD |
PMID:20683903 |
|
NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein] mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein] |
CTD |
PMID:19201465 PMID:23451106 PMID:24095822 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO EXP |
mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] mangiferin inhibits the reaction [Galactosamine results in decreased expression of BCL2 protein] mangiferin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein] |
CTD |
PMID:21420233 PMID:22118634 PMID:23451106 PMID:24095822 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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|
G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of BCL2L1 protein |
CTD |
PMID:21547680 PMID:26996543 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
mangiferin results in decreased expression of BIRC5 protein |
CTD |
PMID:26996543 |
|
NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
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G |
C3 |
complement C3 |
decreases expression |
ISO |
mangiferin results in decreased expression of C3 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
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|
G |
Calcr |
calcitonin receptor |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] |
CTD |
PMID:20683903 |
|
NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein] mangiferin results in increased activity of CASP3 protein mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP3 protein] |
CTD |
PMID:21547680 PMID:22118634 PMID:22310181 PMID:23451106 PMID:26996543 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Casp8 |
caspase 8 |
increases expression |
ISO |
mangiferin results in increased expression of CASP8 protein |
CTD |
PMID:32420661 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO EXP |
mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein] mangiferin inhibits the reaction [Galactosamine results in increased expression of CASP9 protein] |
CTD |
PMID:22118634 PMID:23451106 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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|
G |
Cat |
catalase |
multiple interactions increases activity |
ISO EXP |
mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CAT mRNA]; mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein] mangiferin inhibits the reaction [Mercuric Chloride results in decreased expression of CAT protein] mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] mangiferin results in increased activity of CAT protein |
CTD |
PMID:15161907 PMID:16076520 PMID:16584858 PMID:16697266 PMID:17433543 PMID:18816296 PMID:19201465 PMID:20629087 PMID:23451106 PMID:27125760 PMID:29223569 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression |
ISO |
mangiferin results in decreased expression of CCL2 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein] |
CTD |
PMID:15135318 |
|
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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|
G |
Ccnb1 |
cyclin B1 |
increases expression |
ISO |
mangiferin results in increased expression of CCNB1 mRNA |
CTD |
PMID:20518311 |
|
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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|
G |
Cd36 |
CD36 molecule |
multiple interactions increases expression |
EXP |
dorsomorphin inhibits the reaction [mangiferin results in increased expression of CD36 protein] |
CTD |
PMID:22292039 |
|
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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|
G |
Cdh1 |
cadherin 1 |
increases expression affects expression multiple interactions |
ISO |
mangiferin results in increased expression of CDH1 protein mangiferin affects the expression of CDH1 protein lipopolysaccharide, Escherichia coli O111 B4 affects the reaction [mangiferin affects the expression of CDH1 protein] |
CTD |
PMID:23707762 PMID:32420661 |
|
NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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|
G |
Cdk1 |
cyclin-dependent kinase 1 |
increases expression |
ISO |
mangiferin results in increased expression of CDK1 mRNA |
CTD |
PMID:20518311 |
|
NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
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|
G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO EXP |
mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein] mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein] mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of CHUK protein] |
CTD |
PMID:21420233 PMID:22310181 PMID:23451106 |
|
NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
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|
G |
Cidea |
cell death-inducing DFFA-like effector a |
multiple interactions |
ISO |
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CIDEA mRNA |
CTD |
PMID:32417366 |
|
NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
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|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
mangiferin inhibits the reaction [AGT protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:19706694 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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|
G |
Col4a1 |
collagen type IV alpha 1 chain |
multiple interactions |
EXP |
mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA] |
CTD |
PMID:19706694 |
|
NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression multiple interactions |
EXP |
mangiferin results in increased expression of CPT1A protein dorsomorphin inhibits the reaction [mangiferin results in increased expression of CPT1A protein] |
CTD |
PMID:22292039 |
|
NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions decreases expression |
ISO |
mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein] mangiferin results in decreased expression of CSF2 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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G |
Csf3 |
colony stimulating factor 3 |
multiple interactions decreases expression |
ISO |
mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein] mangiferin results in decreased expression of CSF3 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157
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G |
Ctnnb1 |
catenin beta 1 |
decreases response to substance |
ISO |
CTNNB1 protein results in decreased susceptibility to mangiferin |
CTD |
PMID:23707762 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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|
G |
Ctnnd1 |
catenin delta 1 |
multiple interactions |
ISO |
mangiferin inhibits the reaction [Paraquat results in decreased expression of and affects the localization of CTNND1 protein]; mangiferin inhibits the reaction [Paraquat results in decreased expression of CTNND1 mRNA alternative form] |
CTD |
PMID:24912632 |
|
NCBI chr 3:72,001,904...72,053,047
Ensembl chr 3:72,002,152...72,053,049
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G |
Ctsd |
cathepsin D |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein] |
CTD |
PMID:19172585 |
|
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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G |
Ctsk |
cathepsin K |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] |
CTD |
PMID:20683903 |
|
NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
multiple interactions |
ISO |
mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of CXCR4 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA] |
CTD |
PMID:21420233 PMID:32420661 |
|
NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
mangiferin results in increased expression of CYP1A1 mRNA |
CTD |
PMID:22815239 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity increases expression |
EXP ISO |
mangiferin results in decreased activity of CYP1A2 protein mangiferin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:18053976 PMID:22815239 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases activity |
EXP |
mangiferin results in increased activity of CYP2B1 protein |
CTD |
PMID:18053976 |
|
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
EXP |
mangiferin results in decreased activity of CYP2C6V1 protein |
CTD |
PMID:18053976 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
mangiferin results in decreased activity of CYP2D6 protein |
CTD |
PMID:22815239 |
|
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
EXP |
mangiferin results in decreased activity of CYP2E1 protein |
CTD |
PMID:18053976 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
decreases activity |
EXP |
mangiferin results in decreased activity of CYP3A23-3A1 protein |
CTD |
PMID:18053976 |
|
NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
decreases activity |
ISO |
mangiferin results in decreased activity of CYP3A4 protein |
CTD |
PMID:22815239 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Dcstamp |
dendrocyte expressed seven transmembrane protein |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] |
CTD |
PMID:20683903 |
|
NCBI chr 7:78,725,173...78,756,160
Ensembl chr 7:78,649,875...78,650,906 Ensembl chr 7:78,649,875...78,650,906
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G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
decreases expression affects expression multiple interactions |
EXP |
mangiferin results in decreased expression of DGAT2 protein mangiferin affects the expression of DGAT2 mRNA; mangiferin affects the expression of DGAT2 protein dorsomorphin inhibits the reaction [mangiferin results in increased expression of DGAT2 protein] |
CTD |
PMID:22292039 PMID:25123789 |
|
NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
ISO |
mangiferin inhibits the reaction [Methylmercury Compounds results in increased expression of and results in increased phosphorylation of DNM1L protein] |
CTD |
PMID:28071871 |
|
NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
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|
G |
F10 |
coagulation factor X |
decreases activity |
ISO |
mangiferin analog results in decreased activity of F10 protein |
CTD |
PMID:21732671 |
|
NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
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|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
mangiferin results in increased expression of FAS protein |
CTD |
PMID:17634039 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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|
G |
Fbp1 |
fructose-bisphosphatase 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of FBP1 mRNA |
CTD |
PMID:19028559 |
|
NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
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|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of FN1 protein] |
CTD |
PMID:19706694 |
|
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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|
G |
Gcg |
glucagon |
multiple interactions |
EXP |
[mangiferin co-treated with Sitagliptin Phosphate] results in increased expression of GCG protein alternative form |
CTD |
PMID:22948814 |
|
NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
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|
G |
Glo1 |
glyoxalase 1 |
increases expression multiple interactions |
EXP |
mangiferin results in increased expression of GLO1 mRNA mangiferin results in increased expression of and results in increased activity of GLO1 protein |
CTD |
PMID:24036348 |
|
NCBI chr20:9,273,589...9,291,608
Ensembl chr20:9,273,594...9,291,610
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Streptozocin results in increased activity of GPT protein] |
CTD |
PMID:29223569 |
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NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO EXP |
mangiferin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]; mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein] mangiferin inhibits the reaction [Methylmercury Compounds results in decreased activity of GSR protein] mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein] |
CTD |
PMID:16697266 PMID:18816296 PMID:23451106 PMID:28071871 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gusb |
glucuronidase, beta |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein] |
CTD |
PMID:19172585 |
|
NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Galactosamine results in decreased expression of HMOX1 protein] |
CTD |
PMID:22310181 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression |
ISO |
mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] mangiferin results in decreased expression of ICAM1 mRNA |
CTD |
PMID:15135318 PMID:15161907 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Icam2 |
intercellular adhesion molecule 2 |
decreases expression |
ISO |
mangiferin results in decreased expression of ICAM2 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr10:94,569,889...94,581,218
Ensembl chr10:94,569,890...94,576,512
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G |
Icam5 |
intercellular adhesion molecule 5 |
decreases expression |
ISO |
mangiferin results in decreased expression of ICAM5 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 8:22,050,222...22,057,209
Ensembl chr 8:22,050,222...22,057,209
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G |
Ifnb1 |
interferon beta 1 |
increases expression |
ISO |
mangiferin results in increased expression of IFNB1 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO EXP |
mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CCL5 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CSF3 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA] mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of IFNG mRNA] |
CTD |
PMID:12694877 PMID:15135318 PMID:15177302 PMID:15177305 PMID:15222974 PMID:16716910 PMID:22310181 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO EXP |
mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein] mangiferin inhibits the reaction [Galactosamine results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:21420233 PMID:22310181 |
|
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Galactosamine results in decreased expression of IL10 mRNA] |
CTD |
PMID:22310181 |
|
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il12a |
interleukin 12A |
decreases expression |
ISO |
mangiferin results in decreased expression of IL12A mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
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G |
Il12b |
interleukin 12B |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Galactosamine results in increased expression of IL12B mRNA] |
CTD |
PMID:22310181 |
|
NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Galactosamine results in increased expression of IL18 mRNA] |
CTD |
PMID:22310181 |
|
NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
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G |
Il1a |
interleukin 1 alpha |
decreases expression |
ISO |
mangiferin results in decreased expression of IL1A mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
mangiferin inhibits the reaction [Galactosamine results in increased expression of IL1B mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA] mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein] |
CTD |
PMID:15381052 PMID:22310181 PMID:27125760 PMID:27474068 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il2rb |
interleukin 2 receptor subunit beta |
decreases expression |
ISO |
mangiferin results in decreased expression of IL2RB mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 7:119,701,338...119,716,238
Ensembl chr 7:119,701,251...119,716,238
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO EXP |
mangiferin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein] mangiferin inhibits the reaction [Galactosamine results in increased expression of IL6 mRNA] mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL6 protein]; mangiferin inhibits the reaction [Ketamine results in increased expression of IL6 protein] mangiferin results in decreased expression of IL6 mRNA |
CTD |
PMID:15135318 PMID:21420233 PMID:22310181 PMID:23087136 PMID:27474068 PMID:32420661 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Irf1 |
interferon regulatory factor 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of IRF1 mRNA |
CTD |
PMID:15135318 |
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NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
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G |
Lpl |
lipoprotein lipase |
multiple interactions increases activity increases expression |
ISO |
MK-886 inhibits the reaction [mangiferin results in increased activity of LPL protein]; MK-886 inhibits the reaction [mangiferin results in increased expression of LPL mRNA] |
CTD |
PMID:15975614 |
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NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
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G |
Map3k14 |
mitogen-activated protein kinase kinase kinase 14 |
decreases phosphorylation |
ISO |
mangiferin results in decreased phosphorylation of MAP3K14 protein |
CTD |
PMID:26996543 |
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NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation decreases activity affects binding multiple interactions |
ISO EXP |
mangiferin results in increased phosphorylation of MAPK1 protein mangiferin metabolite results in decreased activity of MAPK1 protein mangiferin metabolite binds to MAPK1 protein mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein] mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 PMID:27474068 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases activity increases phosphorylation |
ISO EXP |
mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] mangiferin metabolite results in decreased activity of MAPK3 protein mangiferin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] mangiferin inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein] mangiferin results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:19201465 PMID:20683903 PMID:22084399 PMID:22465218 PMID:23451106 PMID:27474068 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
decreases expression |
ISO |
mangiferin results in decreased expression of MAPK8 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
decreases expression |
ISO |
mangiferin results in decreased expression of MAPK9 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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G |
Max |
MYC associated factor X |
decreases expression |
ISO |
mangiferin results in decreased expression of MAX mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 6:99,984,260...100,011,460
Ensembl chr 6:99,984,260...100,011,388
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
mangiferin results in decreased expression of MMP7 protein |
CTD |
PMID:23707762 |
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NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions decreases activity |
ISO |
mangiferin results in decreased expression of MMP9 mRNA; mangiferin results in decreased expression of MMP9 protein mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein] mangiferin results in decreased expression of and results in decreased secretion of MMP9 protein mangiferin results in decreased activity of MMP9 protein |
CTD |
PMID:22465218 PMID:23707762 PMID:27125760 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
mangiferin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] |
CTD |
PMID:27125760 |
|
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions |
EXP |
mangiferin affects the reaction [Galactosamine affects the localization of NFE2L2 protein]; mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFE2L2 protein] |
CTD |
PMID:22310181 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein] |
CTD |
PMID:15161907 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions increases expression |
ISO EXP |
mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] mangiferin inhibits the reaction [Galactosamine results in decreased expression of NFKBIA protein] mangiferin results in increased expression of NFKBIA protein mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein] |
CTD |
PMID:15161907 PMID:20683903 PMID:22310181 PMID:23451106 PMID:27474068 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nfkbib |
NFKB inhibitor beta |
decreases expression multiple interactions |
ISO |
mangiferin results in decreased expression of NFKBIB mRNA mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein] |
CTD |
PMID:15135318 PMID:21420233 |
|
NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
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G |
Nfkbie |
NFKB inhibitor epsilon |
decreases expression |
ISO |
mangiferin results in decreased expression of NFKBIE mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 9:17,828,405...17,835,240
Ensembl chr 9:17,828,408...17,835,240
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G |
Nfkbil1 |
NFKB inhibitor like 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of NFKBIL1 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr20:4,823,590...4,839,202
Ensembl chr20:4,822,935...4,839,202
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G |
Ngf |
nerve growth factor |
increases secretion |
ISO |
mangiferin results in increased secretion of NGF protein |
CTD |
PMID:20303935 |
|
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of NLRP3 protein] |
CTD |
PMID:32420661 |
|
NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; mangiferin promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNFB protein] results in increased expression of NOS2 mRNA] mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] |
CTD |
PMID:12694877 PMID:15381052 PMID:22118634 PMID:22310181 PMID:27474068 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Galactosamine results in decreased expression of NQO1 protein] |
CTD |
PMID:22310181 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Per1 |
period circadian regulator 1 |
affects expression multiple interactions |
ISO |
mangiferin affects the expression of PER1 protein mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of PER1 protein] |
CTD |
PMID:32420661 |
|
NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
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G |
Pla2g2a |
phospholipase A2 group IIA |
decreases activity |
ISO |
mangiferin results in decreased activity of PLA2G2A protein |
CTD |
PMID:15177302 |
|
NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
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G |
Plau |
plasminogen activator, urokinase |
multiple interactions |
EXP |
mangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] |
CTD |
PMID:19706694 |
|
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions increases activity |
ISO |
MK-886 inhibits the reaction [mangiferin results in increased activity of PPARA protein] [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARA mRNA |
CTD |
PMID:15975614 PMID:32417366 |
|
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP ISO |
mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein] [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein |
CTD |
PMID:29223569 PMID:32417366 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARGC1A protein |
CTD |
PMID:32417366 |
|
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Prdm16 |
PR/SET domain 16 |
multiple interactions |
ISO |
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 mRNA; [mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PRDM16 protein |
CTD |
PMID:32417366 |
|
NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
EXP |
dorsomorphin inhibits the reaction [mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; mangiferin results in increased phosphorylation of and results in increased activity of PRKAA1 protein |
CTD |
PMID:22292039 |
|
NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions affects expression |
ISO EXP |
mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] mangiferin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] mangiferin affects the expression of PTGS2 mRNA |
CTD |
PMID:15161907 PMID:15381052 PMID:18621015 PMID:19026997 PMID:21420233 PMID:27474068 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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|
G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
mangiferin results in decreased expression of RAF1 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization decreases expression decreases localization |
ISO EXP |
mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein] mangiferin affects the localization of RELA protein mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [Galactosamine results in increased expression of RELA protein] mangiferin results in decreased expression of RELA mRNA mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]; mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein] mangiferin results in decreased localization of RELA protein |
CTD |
PMID:15135318 PMID:15161907 PMID:19182383 PMID:19201465 PMID:20683903 PMID:21547680 PMID:22310181 PMID:23451106 PMID:26996543 PMID:27474068 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Relb |
RELB proto-oncogene, NF-kB subunit |
decreases expression |
ISO |
mangiferin results in decreased expression of RELB mRNA |
CTD |
PMID:15135318 |
|
NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
|
|
G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of RIPK1 mRNA |
CTD |
PMID:15135318 |
|
NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
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G |
Sele |
selectin E |
decreases expression |
ISO |
mangiferin results in decreased expression of SELE mRNA |
CTD |
PMID:15135318 |
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NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
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G |
Selplg |
selectin P ligand |
decreases expression |
ISO |
mangiferin results in decreased expression of SELPLG mRNA |
CTD |
PMID:15135318 |
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NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA] |
CTD |
PMID:19706694 |
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NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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G |
Slc22a1 |
solute carrier family 22 member 1 |
increases expression |
ISO |
mangiferin results in increased expression of SLC22A1 mRNA |
CTD |
PMID:21348301 |
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NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
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G |
Slc22a12 |
solute carrier family 22 member 12 |
decreases expression |
ISO |
mangiferin results in decreased expression of SLC22A12 mRNA; mangiferin results in decreased expression of SLC22A12 protein |
CTD |
PMID:21348301 |
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NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
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G |
Slc22a2 |
solute carrier family 22 member 2 |
increases expression |
ISO |
mangiferin results in increased expression of SLC22A2 mRNA |
CTD |
PMID:21348301 |
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NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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G |
Slc22a4 |
solute carrier family 22 member 4 |
increases expression |
ISO |
mangiferin results in increased expression of SLC22A4 mRNA |
CTD |
PMID:21348301 |
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NCBI chr10:39,334,972...39,373,508
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G |
Slc22a5 |
solute carrier family 22 member 5 |
increases expression |
ISO |
mangiferin results in increased expression of SLC22A5 mRNA |
CTD |
PMID:21348301 |
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NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions increases expression |
ISO EXP |
2-chloro-5-nitrobenzanilide inhibits the reaction [mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]]; mangiferin affects the localization of and results in increased activity of SLC2A4 protein; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Deoxyglucose]; mangiferin promotes the reaction [SLC2A4 protein results in increased uptake of Glucose] mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; mangiferin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] mangiferin results in increased expression of SLC2A4 mRNA |
CTD |
PMID:19477051 PMID:29223569 |
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NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of SNAI1 protein |
CTD |
PMID:23707762 |
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NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
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G |
Snai2 |
snail family transcriptional repressor 2 |
decreases expression |
ISO |
mangiferin results in decreased expression of SNAI2 protein |
CTD |
PMID:23707762 |
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NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
mangiferin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA] |
CTD |
PMID:17433543 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Srd5a2 |
steroid 5 alpha-reductase 2 |
decreases activity |
ISO |
mangiferin results in decreased activity of SRD5A2 protein |
CTD |
PMID:20823678 |
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NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
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G |
Srf |
serum response factor |
decreases expression |
ISO |
mangiferin results in decreased expression of SRF mRNA |
CTD |
PMID:15135318 |
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NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
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G |
Tab1 |
TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of TAB1 mRNA |
CTD |
PMID:15135318 |
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NCBI chr 7:121,350,953...121,382,100
Ensembl chr 7:121,350,965...121,382,088
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G |
Tbk1 |
TANK-binding kinase 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of TBK1 mRNA |
CTD |
PMID:15135318 |
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NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978
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G |
Tert |
telomerase reverse transcriptase |
decreases activity |
ISO |
mangiferin results in decreased activity of TERT protein |
CTD |
PMID:17634039 |
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NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO EXP |
mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA] mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; mangiferin inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; mangiferin inhibits the reaction [Streptozocin results in increased secretion of TGFB1 protein] |
CTD |
PMID:12694877 PMID:19706694 PMID:19960420 |
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NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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G |
Tlr6 |
toll-like receptor 6 |
decreases expression |
ISO |
mangiferin results in decreased expression of TLR6 mRNA |
CTD |
PMID:15135318 |
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NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
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G |
Tlr7 |
toll-like receptor 7 |
decreases expression |
ISO |
mangiferin results in decreased expression of TLR7 mRNA |
CTD |
PMID:15135318 |
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NCBI chr X:28,486,836...28,513,004
Ensembl chr X:28,486,869...28,512,957
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G |
Tlr8 |
toll-like receptor 8 |
decreases expression |
ISO |
mangiferin results in decreased expression of TLR8 mRNA |
CTD |
PMID:15135318 |
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NCBI chr X:28,539,158...28,562,803
Ensembl chr X:28,539,158...28,562,803
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G |
Tlr9 |
toll-like receptor 9 |
decreases expression |
ISO |
mangiferin results in decreased expression of TLR9 mRNA |
CTD |
PMID:15135318 |
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NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression affects expression increases secretion |
ISO EXP |
mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased activity of NFKB1 protein]; mangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; mangiferin inhibits the reaction [TNF protein results in increased degradation of NFKBIB protein]; mangiferin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of CXCR4 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; mangiferin inhibits the reaction [TNF protein results in increased secretion of IL6 protein] mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of NOS2 mRNA]; mangiferin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of NOS2 mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Galactosamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [Isoproterenol results in increased expression of TNF protein] mangiferin results in decreased expression of TNF mRNA mangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]; mangiferin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mangiferin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; mangiferin inhibits the reaction [Scopolamine results in increased expression of TNF protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein] mangiferin affects the expression of TNF protein mangiferin results in increased secretion of TNF protein |
CTD |
PMID:12694877 PMID:15135318 PMID:15161907 PMID:15177305 PMID:15222974 PMID:19172585 PMID:19182383 PMID:20303935 PMID:21420233 PMID:21837981 PMID:22118634 PMID:22310181 PMID:27125760 PMID:27474068 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Tnfrsf11a |
TNF receptor superfamily member 11A |
decreases expression |
ISO |
mangiferin results in decreased expression of TNFRSF11A mRNA |
CTD |
PMID:15135318 |
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NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:20683903 |
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NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
mangiferin inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein] |
CTD |
PMID:10657591 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Tradd |
TNFRSF1A-associated via death domain |
decreases expression |
ISO |
mangiferin results in decreased expression of TRADD mRNA |
CTD |
PMID:15135318 |
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NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
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G |
Traf6 |
TNF receptor associated factor 6 |
decreases expression |
ISO |
mangiferin results in decreased expression of TRAF6 mRNA |
CTD |
PMID:15135318 |
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NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
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G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
ISO |
[mangiferin co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of UCP1 protein |
CTD |
PMID:32417366 |
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NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression decreases activity |
ISO |
mangiferin results in increased expression of UGT1A1 mRNA mangiferin results in decreased activity of UGT1A1 protein |
CTD |
PMID:22815239 |
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NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases expression |
ISO |
mangiferin results in increased expression of UGT1A9 mRNA |
CTD |
PMID:22815239 |
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NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
decreases activity |
ISO |
mangiferin results in decreased activity of UGT2B7 protein |
CTD |
PMID:22815239 |
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NCBI chr14:22,597,103...22,619,968
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G |
Umod |
uromodulin |
affects expression |
ISO |
mangiferin affects the expression of UMOD protein |
CTD |
PMID:21348301 |
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NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
mangiferin results in decreased expression of VCAM1 mRNA |
CTD |
PMID:15135318 |
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NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
mangiferin inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] |
CTD |
PMID:21420233 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Vim |
vimentin |
decreases expression multiple interactions |
ISO |
mangiferin results in decreased expression of VIM protein mangiferin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the expression of VIM protein] |
CTD |
PMID:23707762 PMID:32420661 |
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NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions decreases expression |
ISO |
mangiferin inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] mangiferin results in decreased expression of XIAP protein |
CTD |
PMID:21420233 PMID:21547680 PMID:26996543 |
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NCBI chr X:128,409,425...128,455,786
Ensembl chr X:128,409,472...128,453,000
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