Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:astemizole
go back to main search page
Accession:CHEBI:2896 term browser browse the term
Definition:A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Synonyms:exact_synonym: 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
 related_synonym: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole;   1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole;   Astemison;   Formula=C28H31FN4O;   InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31);   InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N;   SMILES=COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1;   astemizol;   astemizolum
 xref: Beilstein:4830190;   CAS:68844-77-9;   DrugBank:DB00637;   Drug_Central:249;   KEGG:C06832;   KEGG:D00234;   LINCS:LSM-5502
 xref_mesh: MESH:D016589
 xref: Patent:EP5318;   Patent:US4219559


show annotations for term's descendants           Sort by:
astemizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity		 ISO Astemizole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Astemizole results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Ak3 adenylate kinase 3 increases expression ISO Astemizole results in increased expression of AK3 mRNA CTD PMID:20221588 NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361 		JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid increases expression ISO Astemizole results in increased expression of ALAS2 mRNA CTD PMID:20221588 NCBI chr  X:149,330,443...149,353,614
Ensembl chr  X:149,330,371...149,353,634 		JBrowse link
G Angpt2 angiopoietin 2 increases expression ISO Astemizole results in increased expression of ANGPT2 mRNA CTD PMID:20221588 NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Astemizole results in increased expression of ATF3 mRNA CTD PMID:32661532 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236 		JBrowse link
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide increases expression ISO Astemizole results in increased expression of ATP1B1 mRNA CTD PMID:20221588 NCBI chr 1:164,264,668...164,285,924
Ensembl chr 1:164,264,678...164,285,924 		JBrowse link
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide decreases expression ISO Astemizole results in decreased expression of ATP1B2 mRNA CTD PMID:20221588 NCBI chr11:69,490,554...69,496,786
Ensembl chr11:69,490,562...69,496,768 		JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon increases expression ISO Astemizole results in increased expression of ATP5F1E mRNA CTD PMID:20221588 NCBI chr 2:174,302,868...174,305,894
Ensembl chr 2:174,302,865...174,305,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Astemizole results in decreased expression of BCL2 mRNA CTD PMID:20221588 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO Astemizole results in decreased expression of BMP1 mRNA CTD PMID:20221588 NCBI chr14:70,711,998...70,758,280
Ensembl chr14:70,711,998...70,757,674 		JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II, delta decreases expression ISO Astemizole results in decreased expression of CAMK2D mRNA CTD PMID:20221588 NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975 		JBrowse link
G Cat catalase increases expression ISO Astemizole results in increased expression of CAT mRNA CTD PMID:20221588 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO Astemizole results in decreased expression of CCL7 mRNA CTD PMID:20221588 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO Astemizole results in increased expression of CEBPB mRNA CTD PMID:20221588 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma decreases expression ISO Astemizole results in decreased expression of CEBPG mRNA CTD PMID:20221588 NCBI chr 7:34,745,847...34,755,991
Ensembl chr 7:34,745,847...34,755,998 		JBrowse link
G Cfh complement component factor h decreases expression ISO Astemizole results in decreased expression of CFH mRNA CTD PMID:20221588 NCBI chr 1:140,013,593...140,111,149
Ensembl chr 1:140,012,446...140,111,502 		JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO Astemizole results in decreased expression of COLEC12 mRNA CTD PMID:20221588 NCBI chr18:9,707,648...9,877,995
Ensembl chr18:9,707,595...9,882,644 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO Astemizole inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]] CTD PMID:18835572 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Astemizole results in decreased expression of CXCL3 mRNA CTD PMID:20221588 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO Astemizole results in decreased expression of CXCL9 mRNA CTD PMID:20221588 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 decreases methylation
increases metabolic processing
multiple interactions		 ISO CYP2J2 protein results in decreased methylation of Astemizole
CYP2J2 protein results in increased metabolism of Astemizole
Arachidonic Acid inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]; ebastine inhibits the reaction [CYP2J2 protein results in decreased methylation of Astemizole]		 CTD PMID:12386130 PMID:15861034 PMID:17162467 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Eaf1 ELL associated factor 1 increases expression ISO Astemizole results in increased expression of EAF1 mRNA CTD PMID:20221588 NCBI chr14:31,217,036...31,231,815
Ensembl chr14:31,216,356...31,231,815 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression ISO Astemizole results in increased expression of EGLN1 mRNA CTD PMID:20221588 NCBI chr 8:125,635,325...125,676,063
Ensembl chr 8:125,635,326...125,676,063 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 increases expression ISO Astemizole results in increased expression of EIF4A1 mRNA CTD PMID:20221588 NCBI chr11:69,557,762...69,563,249
Ensembl chr11:69,557,762...69,563,249 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression ISO Astemizole results in decreased expression of ERRFI1 mRNA CTD PMID:20221588 NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349 		JBrowse link
G Etv5 ets variant 5 decreases expression ISO Astemizole results in decreased expression of ETV5 mRNA CTD PMID:20221588 NCBI chr16:22,200,063...22,258,320
Ensembl chr16:22,200,059...22,258,469 		JBrowse link
G Fam124a family with sequence similarity 124, member A increases expression ISO Astemizole results in increased expression of FAM124A mRNA CTD PMID:20221588 NCBI chr14:62,793,186...62,845,935
Ensembl chr14:62,793,186...62,845,935 		JBrowse link
G Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide multiple interactions ISO Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein] CTD PMID:9088877 NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781 		JBrowse link
G Gdf10 growth differentiation factor 10 increases expression ISO Astemizole results in increased expression of GDF10 mRNA CTD PMID:20221588 NCBI chr14:33,645,544...33,658,471
Ensembl chr14:33,645,544...33,659,940 		JBrowse link
G Gimap1 GTPase, IMAP family member 1 increases expression ISO Astemizole results in increased expression of GIMAP1 mRNA CTD PMID:20221588 NCBI chr 6:48,715,981...48,720,729
Ensembl chr 6:48,715,988...48,720,729 		JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Astemizole results in increased expression of GPM6B mRNA CTD PMID:20221588 NCBI chr  X:165,021,911...165,172,028
Ensembl chr  X:165,021,907...165,171,984 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO Astemizole results in increased expression of GPX4 mRNA CTD PMID:20221588 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Hexb hexosaminidase B increases secretion
multiple interactions		 ISO Astemizole results in increased secretion of HEXB protein
Astemizole inhibits the reaction [FCER1A protein results in increased secretion of HEXB protein]		 CTD PMID:9088877 NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Astemizole results in increased expression of HMOX1 mRNA CTD PMID:32661532 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hrh1 histamine receptor H1 multiple interactions EXP
ISO		 [Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline
Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]		 CTD PMID:12147327 PMID:16129921 NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 decreases expression ISO Astemizole results in decreased expression of HSP90AB1 mRNA CTD PMID:20221588 NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197 		JBrowse link
G Hspa8 heat shock protein 8 increases expression ISO Astemizole results in increased expression of HSPA8 mRNA CTD PMID:20221588 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Hspb8 heat shock protein 8 increases expression ISO Astemizole results in increased expression of HSPB8 mRNA CTD PMID:20221588 NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923 		JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 decreases expression ISO Astemizole results in decreased expression of HSPH1 mRNA CTD PMID:20221588 NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein] CTD PMID:17517105 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Astemizole results in decreased expression of IFIT3 mRNA CTD PMID:20221588 NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igsf6 immunoglobulin superfamily, member 6 decreases expression ISO Astemizole results in decreased expression of IGSF6 mRNA CTD PMID:20221588 NCBI chr 7:120,663,290...120,673,753
Ensembl chr 7:120,663,290...120,673,795 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:17517105 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il36rn interleukin 36 receptor antagonist increases expression ISO Astemizole results in increased expression of IL36RN mRNA CTD PMID:20221588 NCBI chr 2:24,166,966...24,172,444
Ensembl chr 2:24,166,966...24,173,438 		JBrowse link
G Il7r interleukin 7 receptor decreases expression ISO Astemizole results in decreased expression of IL7R mRNA CTD PMID:20221588 NCBI chr15:9,505,880...9,530,270
Ensembl chr15:9,505,874...9,530,262 		JBrowse link
G Itga8 integrin alpha 8 increases expression ISO Astemizole results in increased expression of ITGA8 mRNA CTD PMID:20221588 NCBI chr 2:12,111,443...12,306,755
Ensembl chr 2:12,111,443...12,306,733 		JBrowse link
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 multiple interactions
affects binding
decreases activity		 ISO Astemizole binds to and results in decreased activity of KCNH1 protein; Astemizole inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
Astemizole binds to KCNH1 protein
Astemizole results in decreased activity of KCNH1 protein		 CTD PMID:14985237 PMID:16816845 PMID:17520698 PMID:18471075 PMID:18497958 More... NCBI chr 1:191,871,759...192,192,467
Ensembl chr 1:191,873,082...192,192,467 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions
decreases activity
affects localization
affects binding		 ISO
EXP		 Astemizole binds to and results in decreased activity of KCNH2 protein; Astemizole inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]; Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]; Astemizole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein]
Astemizole affects the localization of KCNH2 protein mutant form
Astemizole binds to KCNH2 gene polymorphism; Astemizole binds to KCNH2 protein		 CTD PMID:8641472 PMID:9658196 PMID:10376921 PMID:10422790 PMID:10531299 More... NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] CTD PMID:12147327 NCBI chr 2:180,717,372...180,777,368
Ensembl chr 2:180,717,372...180,777,093 		JBrowse link
G Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 multiple interactions ISO Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]] CTD PMID:12147327 NCBI chr15:65,858,223...66,158,485
Ensembl chr15:65,858,236...66,158,491 		JBrowse link
G Maoa monoamine oxidase A decreases expression ISO Astemizole results in decreased expression of MAOA mRNA CTD PMID:20221588 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Mapt microtubule-associated protein tau affects binding ISO Astemizole binds to MAPT protein alternative form CTD PMID:20110603 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Astemizole results in decreased expression of MMP2 mRNA CTD PMID:20221588 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Ms4a6c membrane-spanning 4-domains, subfamily A, member 6C decreases expression ISO Astemizole results in decreased expression of MS4A6A mRNA CTD PMID:20221588 NCBI chr19:11,446,718...11,464,433
Ensembl chr19:11,446,730...11,459,556 		JBrowse link
G Mt2 metallothionein 2 increases expression ISO Astemizole results in increased expression of MT2A mRNA CTD PMID:32661532 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mtf1 metal response element binding transcription factor 1 multiple interactions ISO MTF1 protein affects the reaction [Astemizole results in increased expression of MT1M mRNA] CTD PMID:32661532 NCBI chr 4:124,696,342...124,743,593
Ensembl chr 4:124,695,897...124,743,593 		JBrowse link
G Mtus1 mitochondrial tumor suppressor 1 decreases expression ISO Astemizole results in decreased expression of MTUS1 mRNA CTD PMID:20221588 NCBI chr 8:41,443,949...41,587,318
Ensembl chr 8:41,443,951...41,586,763 		JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha increases expression ISO Astemizole results in increased expression of MYH6 mRNA CTD PMID:20221588 NCBI chr14:55,179,378...55,205,553
Ensembl chr14:55,179,378...55,204,384 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 increases expression ISO Astemizole results in increased expression of NDUFS7 mRNA CTD PMID:20221588 NCBI chr10:80,084,939...80,092,628
Ensembl chr10:80,084,955...80,092,628 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression ISO Astemizole results in increased expression of NDUFV2 mRNA CTD PMID:20221588 NCBI chr17:66,385,790...66,408,554
Ensembl chr17:66,385,633...66,408,554 		JBrowse link
G Necab1 N-terminal EF-hand calcium binding protein 1 decreases expression ISO Astemizole results in decreased expression of NECAB1 mRNA CTD PMID:20221588 NCBI chr 4:14,952,245...15,149,804
Ensembl chr 4:14,952,245...15,149,794 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO Astemizole results in increased expression of NR4A3 mRNA CTD PMID:20221588 NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447 		JBrowse link
G Oasl1 2'-5' oligoadenylate synthetase-like 1 decreases expression ISO Astemizole results in decreased expression of OASL1 mRNA CTD PMID:20221588 NCBI chr 5:115,061,236...115,075,970
Ensembl chr 5:115,061,299...115,075,974 		JBrowse link
G Osbpl3 oxysterol binding protein-like 3 increases expression ISO Astemizole results in increased expression of OSBPL3 mRNA CTD PMID:20221588 NCBI chr 6:50,270,307...50,433,334
Ensembl chr 6:50,270,310...50,433,181 		JBrowse link
G Osgepl1 O-sialoglycoprotein endopeptidase-like 1 increases expression ISO Astemizole results in increased expression of OSGEPL1 mRNA CTD PMID:20221588 NCBI chr 1:53,352,070...53,365,502
Ensembl chr 1:53,352,783...53,365,502 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 increases expression ISO Astemizole results in increased expression of PARK7 mRNA CTD PMID:20221588 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Pcdh17 protocadherin 17 decreases expression ISO Astemizole results in decreased expression of PCDH17 mRNA CTD PMID:20221588 NCBI chr14:84,680,626...84,775,005
Ensembl chr14:84,681,003...84,776,442 		JBrowse link
G Peli2 pellino 2 increases expression ISO Astemizole results in increased expression of PELI2 mRNA CTD PMID:20221588 NCBI chr14:48,358,096...48,519,035
Ensembl chr14:48,358,280...48,519,032 		JBrowse link
G Psmb5 proteasome (prosome, macropain) subunit, beta type 5 increases expression ISO Astemizole results in increased expression of PSMB5 mRNA CTD PMID:20221588 NCBI chr14:54,851,577...54,855,452
Ensembl chr14:54,851,576...54,855,479 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Astemizole results in decreased expression of PTGS1 mRNA CTD PMID:20221588 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Pycr3 pyrroline-5-carboxylate reductase 3 increases expression ISO Astemizole results in increased expression of PYCR3 mRNA CTD PMID:20221588 NCBI chr15:75,788,319...75,793,369
Ensembl chr15:75,788,326...75,793,409 		JBrowse link
G Pygm muscle glycogen phosphorylase increases expression ISO Astemizole results in increased expression of PYGM mRNA CTD PMID:20221588 NCBI chr19:6,434,438...6,448,494
Ensembl chr19:6,434,429...6,448,489 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO Astemizole results in increased expression of S100A8 mRNA CTD PMID:20221588 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100b S100 protein, beta polypeptide, neural decreases expression ISO Astemizole results in decreased expression of S100B mRNA CTD PMID:20221588 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Sik1 salt inducible kinase 1 decreases expression ISO Astemizole results in decreased expression of SIK1 mRNA CTD PMID:20221588 NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778 		JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 increases expression ISO Astemizole results in increased expression of SLC1A1 mRNA CTD PMID:20221588 NCBI chr19:28,812,535...28,891,360
Ensembl chr19:28,812,449...28,891,360 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO Astemizole results in increased expression of SOD2 mRNA CTD PMID:20221588 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Astemizole results in increased expression of SQSTM1 mRNA CTD PMID:20221588 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression ISO Astemizole results in increased expression of TGFB2 mRNA CTD PMID:20221588 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Astemizole results in decreased expression of TLR2 mRNA CTD PMID:20221588 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr7 toll-like receptor 7 decreases expression ISO Astemizole results in decreased expression of TLR7 mRNA CTD PMID:20221588 NCBI chr  X:166,086,376...166,113,570
Ensembl chr  X:166,087,925...166,113,554 		JBrowse link
G Tmod1 tropomodulin 1 increases expression ISO Astemizole results in increased expression of TMOD1 mRNA CTD PMID:20221588 NCBI chr 4:46,038,940...46,116,032
Ensembl chr 4:46,038,935...46,116,032 		JBrowse link
G Trf transferrin decreases expression ISO Astemizole results in decreased expression of TF mRNA CTD PMID:20221588 NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Astemizole inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:17517105 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vcan versican decreases expression ISO Astemizole results in decreased expression of VCAN mRNA CTD PMID:20221588 NCBI chr13:89,803,429...89,891,146
Ensembl chr13:89,803,431...89,890,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22304
    role 22290
      biological role 22289
        antimicrobial agent 19676
          antiviral agent 11731
            anticoronaviral agent 10141
              astemizole 86
Path 2
Term Annotations click to browse term
  CHEBI ontology 22304
    subatomic particle 22299
      composite particle 22299
        hadron 22299
          baryon 22299
            nucleon 22299
              atomic nucleus 22299
                atom 22299
                  main group element atom 22180
                    p-block element atom 22180
                      carbon group element atom 21982
                        carbon atom 21922
                          organic molecular entity 21922
                            organic molecule 21750
                              organic cyclic compound 21368
                                organic heterocyclic compound 20382
                                  organic heteropolycyclic compound 19677
                                    organic heterobicyclic compound 18252
                                      benzimidazoles 1183
                                        astemizole 86
paths to the root