Cfh (complement component factor h) - Rat Genome Database

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Gene: Cfh (complement component factor h) Mus musculus
Analyze
Symbol: Cfh
Name: complement component factor h
RGD ID: 733427
MGI Page MGI
Description: Enables complement component C3b binding activity and heparin binding activity. Acts upstream of or within several processes, including complement activation; retina development in camera-type eye; and skeletal system development. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; humerus cartilage condensation; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement factor H; complement factor H related protein 3A4/5G4; Mud-1; NOM; protein beta-1-H; S; Sa; Sas-1; Sas1
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm16332  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBIGRCm39mm39
GRCm39 Ensembl1140,012,446 - 140,111,502 (-)Ensembl
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIGRCm37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBImm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 4  (IEA,ISO)
amphetamine abuse  (ISO)
anterior uveitis  (ISO)
atypical hemolytic-uremic syndrome  (IEA,ISO)
Bacteremia  (ISO)
basal laminar drusen  (ISO)
brain infarction  (ISO)
C3 Glomerulopathy 3  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic kidney disease  (ISO)
Complement Factor H Deficiency  (ISO)
COVID-19  (ISO)
diabetic retinopathy  (ISO)
Experimental Arthritis  (IDA)
gastrointestinal stromal tumor  (ISO)
glaucoma  (ISO)
glomerulonephritis  (IMP)
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency  (IMP,ISO)
hemolytic-uremic syndrome  (IEA,ISO)
Hemorrhagic Shock  (ISO)
Intestinal Ischemia  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (IEA,ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
multiple sclerosis  (ISO)
nephrosis  (ISO)
obstructive jaundice  (ISO)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
Pneumococcal Infections  (IMP,ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
posterior uveitis  (ISO)
primary immunodeficiency disease  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinal drusen  (ISO)
sarcoidosis  (ISO)
Sepsis  (ISO)
squamous cell carcinoma  (ISO)
Stroke  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
Thrombotic Microangiopathies  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
astemizole  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
chlorpromazine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP,ISO)
flutamide  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
isoprenaline  (EXP)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
olanzapine  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tamoxifen  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of membrane attack complex  (IMP)
angiogenesis  (IMP)
ATP metabolic process  (IMP)
bone development  (IGI)
cartilage development  (IGI)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (IGI,ISO)
complement activation  (IBA,IDA,IGI,IMP,ISO)
complement activation, alternative pathway  (IGI,IMP)
creatinine homeostasis  (IGI)
determination of adult lifespan  (IMP)
gene expression  (IMP)
glomerulus development  (IGI,IMP)
immune complex clearance  (IGI)
immune response  (IMP)
immune system process  (IEA)
immunoglobulin mediated immune response  (IGI)
inflammatory response  (IGI,IMP)
inflammatory response to wounding  (IGI)
innate immune response  (IEA)
kidney development  (IGI,IMP)
mitochondrial DNA metabolic process  (IMP)
mitochondrial gene expression  (IMP)
mitochondrion organization  (IMP)
monocyte aggregation  (IMP)
neuromuscular process  (IMP)
neutrophil homeostasis  (IGI)
organ or tissue specific immune response  (IGI)
organelle localization  (IMP)
photoreceptor cell differentiation  (IMP)
platelet aggregation  (IMP)
proteolysis  (ISO)
regulation of complement activation  (IMP,ISO)
regulation of complement activation, alternative pathway  (ISO)
regulation of complement-dependent cytotoxicity  (ISO)
response to cytokine  (IDA)
response to dietary excess  (IMP)
retina development in camera-type eye  (IGI,IMP)
retinal pigment epithelium development  (IMP)
retinal rod cell development  (IMP)
vascular associated smooth muscle cell differentiation  (IGI,IMP)
visual perception  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal brain thrombosis  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal circulating complement protein level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal complement protein level  (IAGP)
abnormal glomerular capillary endothelium morphology  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glomerular capillary thrombosis  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal hepatic portal vein thrombosis  (IAGP)
abnormal kidney blood vessel morphology  (IAGP)
abnormal kidney capillary morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney thrombosis  (IAGP)
abnormal kidney venous thrombosis  (IAGP)
abnormal lung thrombosis  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina rod bipolar cell morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal thrombosis  (IAGP)
albuminuria  (IAGP)
amyloid beta deposits  (IAGP)
anasarca  (IAGP)
anemia  (IAGP)
artery occlusion  (IAGP)
brain ischemia  (IAGP)
circling  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body size  (IAGP)
decreased circulating complement protein level  (IAGP)
decreased complement C5 level  (IAGP)
decreased hemoglobin content  (IAGP)
decreased serum complement activity  (IAGP)
decreased visual acuity  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
expanded mesangial matrix  (IAGP)
glomerulonephritis  (IAGP)
hematuria  (IAGP)
hindlimb paralysis  (IAGP)
impaired muscle relaxation  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased creatine level  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased mesangial cell number  (IAGP)
increased susceptibility to type III hypersensitivity reaction  (IAGP)
increased susceptilbility to retina ischemic injury  (IAGP)
increased urine protein level  (IAGP)
intracerebral hemorrhage  (IAGP)
kidney failure  (IAGP)
mesangial cell interposition  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
renal glomerular protein deposits  (IAGP)
reticulocytosis  (IAGP)
retina detachment  (IAGP)
schistocytosis  (IAGP)
thrombocytopenia  (IAGP)
white pupil  (IAGP)
References

References - curated
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Additional References at PubMed
PMID:540002   PMID:1311971   PMID:1486806   PMID:1495973   PMID:1689298   PMID:1834169   PMID:2071146   PMID:2136885   PMID:2165966   PMID:2522412   PMID:2533512   PMID:2564419  
PMID:2574151   PMID:2878046   PMID:2892757   PMID:2895697   PMID:2940596   PMID:2972715   PMID:2993224   PMID:3156187   PMID:3384439   PMID:3416634   PMID:4955525   PMID:4992636  
PMID:6308669   PMID:6332054   PMID:6934364   PMID:6967858   PMID:6973596   PMID:7165695   PMID:7410386   PMID:7474114   PMID:7558020   PMID:7894156   PMID:8075500   PMID:8422330  
PMID:8468048   PMID:8482578   PMID:8615824   PMID:10349636   PMID:10693874   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11489951   PMID:11739537   PMID:12091909   PMID:12477932  
PMID:12914820   PMID:15574507   PMID:15582152   PMID:16023208   PMID:16141072   PMID:16141073   PMID:16597679   PMID:16602821   PMID:16769899   PMID:16829211   PMID:16849499   PMID:16936129  
PMID:16944957   PMID:17028856   PMID:17330941   PMID:17410102   PMID:17420242   PMID:17562771   PMID:17921253   PMID:18202746   PMID:18554416   PMID:18947875   PMID:19299737   PMID:19411110  
PMID:19458267   PMID:19541934   PMID:19620346   PMID:20445496   PMID:20538999   PMID:20675597   PMID:20702729   PMID:20813971   PMID:20854881   PMID:20962256   PMID:21148254   PMID:21148255  
PMID:21267068   PMID:21302086   PMID:21544060   PMID:21677750   PMID:21862448   PMID:21873635   PMID:21920606   PMID:21979047   PMID:22174452   PMID:22219359   PMID:22819137   PMID:22832515  
PMID:22875704   PMID:22918646   PMID:23029250   PMID:23133374   PMID:23184055   PMID:23204401   PMID:23436934   PMID:23469078   PMID:23487775   PMID:23747511   PMID:23799019   PMID:23844226  
PMID:24006456   PMID:24279761   PMID:24370827   PMID:24550112   PMID:24664701   PMID:24929970   PMID:25284781   PMID:25447048   PMID:25565310   PMID:25684976   PMID:25921262   PMID:25991857  
PMID:26030099   PMID:26149919   PMID:26374608   PMID:26768663   PMID:27165610   PMID:27397653   PMID:27564415   PMID:27918307   PMID:28057640   PMID:28228282   PMID:28535371   PMID:29070671  
PMID:29389016   PMID:29392311   PMID:29858280   PMID:30107932   PMID:30642982   PMID:30705315   PMID:30711487   PMID:30808757   PMID:30972735   PMID:31133737   PMID:31354740   PMID:31409673  
PMID:32165615   PMID:32325033   PMID:32369457   PMID:32376801   PMID:32737203   PMID:32849636   PMID:32962822   PMID:33410734   PMID:33558624   PMID:33708358   PMID:33859044   PMID:33953184  
PMID:34054871   PMID:34139209   PMID:34775843  


Genomics

Comparative Map Data
Cfh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBIGRCm39mm39
GRCm39 Ensembl1140,012,446 - 140,111,502 (-)Ensembl
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIGRCm37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBImm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
CFH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,652,043 - 196,747,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1196,651,754 - 196,752,476 (+)EnsemblGRCh38hg38GRCh38
GRCh371196,621,173 - 196,716,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,887,764 - 194,983,257 (+)NCBINCBI36hg18NCBI36
Build 341193,352,831 - 193,448,257NCBI
Celera1169,729,995 - 169,825,611 (+)NCBI
Cytogenetic Map1q31.3NCBI
HuRef1167,862,965 - 167,958,566 (+)NCBIHuRef
CHM1_11198,042,727 - 198,138,292 (+)NCBICHM1_1
T2T-CHM13v2.01195,998,386 - 196,093,925 (+)NCBI
Cfh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21351,512,376 - 51,613,829 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)Ensembl
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Celera1351,770,541 - 51,871,522 (-)NCBICelera
Cytogenetic Map13q13NCBI
CFH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11176,434,107 - 176,507,049 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,455,247 - 176,525,521 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01172,155,882 - 172,251,632 (+)NCBIMhudiblu_PPA_v0panPan3
CFH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,878,677 - 2,956,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,970,756 - 3,047,389 (-)NCBI
ROS_Cfam_1.0382,876,209 - 2,953,077 (-)NCBI
ROS_Cfam_1.0 Ensembl382,875,485 - 2,953,035 (-)Ensembl
UMICH_Zoey_3.1382,869,120 - 2,945,692 (-)NCBI
UNSW_CanFamBas_1.0383,262,568 - 3,340,656 (-)NCBI
UU_Cfam_GSD_1.0383,463,162 - 3,540,549 (-)NCBI
CFH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21024,337,539 - 24,406,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,557,697 - 32,744,763 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBIVero_WHO_p1.0
Cfh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247983,332,549 - 3,414,435 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Cfh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381140,162,588 - 140,163,133UniSTSGRCm38
MGSCv371142,059,165 - 142,059,710UniSTSGRCm37
Celera1142,791,271 - 142,791,816UniSTS
Cytogenetic Map1FUniSTS
cM Map174.1UniSTS
Cfh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381139,774,492 - 139,774,577UniSTSGRCm38
MGSCv371141,671,069 - 141,671,154UniSTSGRCm37
Celera1142,421,498 - 142,421,583UniSTS
Cytogenetic Map1FUniSTS
Cfh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1FUniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:546
Count of miRNA genes:243
Interacting mature miRNAs:262
Transcripts:ENSMUST00000066859, ENSMUST00000111976, ENSMUST00000111977, ENSMUST00000123238, ENSMUST00000148225
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066859   ⟹   ENSMUSP00000066677
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,597 - 140,111,149 (-)Ensembl
GRCm38.p6 Ensembl1140,085,859 - 140,183,411 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111976   ⟹   ENSMUSP00000107607
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,593 - 140,111,149 (-)Ensembl
GRCm38.p6 Ensembl1140,085,855 - 140,183,411 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111977   ⟹   ENSMUSP00000107608
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,596 - 140,111,058 (-)Ensembl
GRCm38.p6 Ensembl1140,085,858 - 140,183,320 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123238   ⟹   ENSMUSP00000115166
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,617 - 140,111,060 (-)Ensembl
GRCm38.p6 Ensembl1140,085,879 - 140,183,322 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148225
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,072,957 - 140,111,149 (-)Ensembl
GRCm38.p6 Ensembl1140,145,219 - 140,183,411 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192880   ⟹   ENSMUSP00000141209
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,012,446 - 140,111,018 (-)Ensembl
GRCm38.p6 Ensembl1140,084,708 - 140,183,280 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192919   ⟹   ENSMUSP00000141634
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,600 - 140,075,550 (-)Ensembl
GRCm38.p6 Ensembl1140,085,862 - 140,147,812 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194688
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,110,872 - 140,111,502 (-)Ensembl
GRCm38.p6 Ensembl1140,183,134 - 140,183,764 (-)Ensembl
RefSeq Acc Id: NM_009888   ⟹   NP_034018
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391140,013,593 - 140,111,149 (-)NCBI
GRCm381140,085,855 - 140,183,411 (-)ENTREZGENE
MGSCv371141,982,432 - 142,079,988 (-)RGD
Celera1142,720,865 - 142,812,024 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034018   ⟸   NM_009888
- Peptide Label: precursor
- UniProtKB: P06909 (UniProtKB/Swiss-Prot),   E9Q8I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000066677   ⟸   ENSMUST00000066859
RefSeq Acc Id: ENSMUSP00000107607   ⟸   ENSMUST00000111976
RefSeq Acc Id: ENSMUSP00000107608   ⟸   ENSMUST00000111977
RefSeq Acc Id: ENSMUSP00000141209   ⟸   ENSMUST00000192880
RefSeq Acc Id: ENSMUSP00000141634   ⟸   ENSMUST00000192919
RefSeq Acc Id: ENSMUSP00000115166   ⟸   ENSMUST00000123238
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06909-F1-model_v2 AlphaFold P06909 1-1234 view protein structure

Promoters
RGD ID:6875162
Promoter ID:EPDNEW_M1031
Type:initiation region
Name:Cfh_1
Description:Mus musculus complement component factor h , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381140,183,301 - 140,183,361EPDNEW
RGD ID:6817506
Promoter ID:MM_KWN:2322
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:NM_009888,   OTTMUST00000060597,   OTTMUST00000060599,   UC007CWT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361142,079,571 - 142,080,071 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88385 AgrOrtholog
Ensembl Genes ENSMUSG00000026365 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000066677 UniProtKB/Swiss-Prot
  ENSMUSP00000107607 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000107608 UniProtKB/TrEMBL
  ENSMUSP00000115166 UniProtKB/TrEMBL
  ENSMUSP00000141209 UniProtKB/TrEMBL
  ENSMUSP00000141634 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066859 UniProtKB/Swiss-Prot
  ENSMUST00000111976 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000111977 UniProtKB/TrEMBL
  ENSMUST00000123238 UniProtKB/TrEMBL
  ENSMUST00000192880 UniProtKB/TrEMBL
  ENSMUST00000192919 UniProtKB/TrEMBL
InterPro Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12628 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88385 ENTREZGENE
NCBI Gene 12628 ENTREZGENE
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfh PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YVP8_MOUSE UniProtKB/TrEMBL
  A0A0A6YWP4_MOUSE UniProtKB/TrEMBL
  CFAH_MOUSE UniProtKB/Swiss-Prot
  D6RGQ0_MOUSE UniProtKB/TrEMBL
  E9Q8H9_MOUSE UniProtKB/TrEMBL
  E9Q8I0 ENTREZGENE, UniProtKB/TrEMBL
  P06909 ENTREZGENE
  Q8C5S1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q6NZK3 UniProtKB/Swiss-Prot