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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:simazine
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Accession:CHEBI:27496 term browser browse the term
Definition:A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Synonyms:exact_synonym: 6-chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine
 related_synonym: 2-chloro-4,6-bis(ethylamino)-1,3,5-triazine;   2-chloro-4,6-bis(ethylamino)-s-triazine;   6-chloro-N(2),N(4)-diethyl-1,3,5-triazine-2,4-diamine;   6-chloro-N,N'-diethyl-[1,3,5]triazin-2,4-diamine;   Formula=C7H12ClN5;   Gesatop;   InChI=1S/C7H12ClN5/c1-3-9-6-11-5(8)12-7(13-6)10-4-2/h3-4H2,1-2H3,(H2,9,10,11,12,13);   InChIKey=ODCWYMIRDDJXKW-UHFFFAOYSA-N;   Princep;   SMILES=CCNc1nc(Cl)nc(NCC)n1;   Simanex
 alt_id: CHEBI:26679;   CHEBI:9146
 xref: Beilstein:10895;   CAS:122-34-9;   KEGG:C11172;   LINCS:LSM-19997
 xref_mesh: MESH:D012839
 xref: MetaCyc:CPD-9355;   PMID:12791541;   PMID:14640584;   PMID:15149137;   PMID:19101008;   PPDB:592;   Pesticides:simazine;   Reaxys:10895;   UM-BBD_compID:c0254;   Wikipedia:Simazine



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simazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin receptor IIB decreases expression ISO Simazine results in decreased expression of SCGB2A2 mRNA CTD PMID:15519604 NCBI chr 9:119,231,081...119,271,214
Ensembl chr 9:119,231,184...119,264,061
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein; U 0126 inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27431321 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression EXP Simazine results in decreased expression of BCL2 mRNA CTD PMID:25461544 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b decreases expression EXP Simazine results in decreased expression of BCL2A1 mRNA CTD PMID:25461544 NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880
JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression EXP Simazine results in decreased expression of BCL2L1 mRNA CTD PMID:25461544 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bcl2l2 BCL2-like 2 decreases expression EXP Simazine results in decreased expression of BCL2L2 mRNA CTD PMID:25461544 NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691
JBrowse link
G Ccnb1 cyclin B1 decreases expression EXP Simazine results in decreased expression of CCNB1 mRNA CTD PMID:25461544 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
JBrowse link
G Ccnd2 cyclin D2 decreases expression EXP Simazine results in decreased expression of CCND2 mRNA CTD PMID:25461544 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156
JBrowse link
G Comt catechol-O-methyltransferase decreases expression
increases expression
EXP
ISO
Simazine results in decreased expression of COMT mRNA; Simazine results in decreased expression of COMT protein
Simazine results in increased expression of COMT mRNA
CTD PMID:29115391 PMID:29137186 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602
JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression EXP Simazine results in decreased expression of CREB5 mRNA CTD PMID:22984576 NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO formestane inhibits the reaction [Simazine results in increased activity of CYP19A1 protein]
Simazine results in increased expression of CYP19A1 mRNA
CTD PMID:10746939 PMID:11675267 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of Simazine CTD PMID:16248553 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
decreases response to substance
ISO Simazine results in increased activity of CYP1A2 protein
Simazine results in increased expression of CYP1A2 protein
CYP1A2 protein results in decreased susceptibility to Simazine
CTD PMID:9711812 PMID:26771455 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene decreases activity ISO Simazine results in decreased activity of CYP2C11 protein CTD PMID:9711812 NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B increases activity
increases expression
ISO Simazine results in increased activity of CYP4A22 protein
Simazine results in increased expression of CYP4A22 protein
CTD PMID:9711812 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231
JBrowse link
G Dbh dopamine beta hydroxylase multiple interactions
decreases expression
ISO Colforsin inhibits the reaction [Simazine results in decreased expression of DBH protein]; Dexamethasone inhibits the reaction [Simazine results in decreased expression of DBH protein] CTD PMID:14550852 NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
JBrowse link
G Ddc dopa decarboxylase affects expression
decreases expression
EXP
ISO
Simazine affects the expression of DDC mRNA; Simazine affects the expression of DDC protein
Simazine results in decreased expression of DDC mRNA; Simazine results in decreased expression of DDC protein
CTD PMID:29115391 PMID:29137186 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144
JBrowse link
G Dtwd2 DTW domain containing 2 increases expression EXP Simazine results in increased expression of DTWD2 mRNA CTD PMID:22984576 NCBI chr18:49,829,212...49,890,255
Ensembl chr18:49,829,212...49,888,668
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
affects binding
ISO Simazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]
Simazine binds to ESR1 protein
CTD PMID:8858116 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects expression ISO Simazine affects the expression of GPER1 mRNA CTD PMID:26955487 NCBI chr 5:139,408,905...139,413,555
Ensembl chr 5:139,408,906...139,413,555
JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP Simazine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011
JBrowse link
G Ifng interferon gamma decreases expression ISO Simazine results in decreased expression of IFNG protein CTD PMID:10883730 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression EXP Simazine results in decreased expression of KIT mRNA CTD PMID:25461544 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382
JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha increases expression
multiple interactions
decreases expression
EXP Simazine results in increased expression of LMX1A mRNA; Simazine results in increased expression of LMX1A protein
LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 protein]; LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 protein]; LMX1A protein promotes the reaction [Simazine results in increased expression of TH protein]; LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 protein]
Simazine results in decreased expression of LMX1A mRNA; Simazine results in decreased expression of LMX1A protein
CTD PMID:32822773 PMID:34936186 NCBI chr 1:167,515,864...167,676,310
Ensembl chr 1:167,516,806...167,676,310
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta increases expression EXP Simazine results in increased expression of LMX1B mRNA; Simazine results in increased expression of LMX1B protein CTD PMID:27513680 PMID:32822773 NCBI chr 2:33,450,977...33,531,219
Ensembl chr 2:33,450,977...33,530,620
JBrowse link
G Maoa monoamine oxidase A decreases expression
affects expression
EXP
ISO
Simazine results in decreased expression of MAOA mRNA
Simazine affects the expression of MAOA mRNA
CTD PMID:29115391 PMID:29137186 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Simazine results in decreased expression of MAOB protein CTD PMID:29137186 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; U 0126 inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein] CTD PMID:27431321 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein; U 0126 inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein] CTD PMID:27431321 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression EXP Simazine results in decreased expression of MCM7 mRNA CTD PMID:25461544 NCBI chr 5:138,162,845...138,170,675
Ensembl chr 5:138,162,845...138,170,684
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP Simazine results in decreased expression of MMP9 mRNA CTD PMID:22984576 PMID:27431321 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
JBrowse link
G Mos Moloney sarcoma oncogene increases expression EXP Simazine results in increased expression of MOS mRNA CTD PMID:22984576 NCBI chr 4:3,870,658...3,872,105
Ensembl chr 4:3,870,657...3,872,105
JBrowse link
G Neurog2 neurogenin 2 increases expression EXP Simazine results in increased expression of NEUROG2 mRNA CTD PMID:27513680 NCBI chr 3:127,426,382...127,429,285
Ensembl chr 3:127,426,784...127,429,280
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP Simazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression
multiple interactions
EXP
ISO
Simazine results in decreased expression of NOS2 mRNA; Simazine results in decreased expression of NOS2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS2 protein]; U 0126 inhibits the reaction [Simazine results in decreased expression of NOS2 protein]
CTD PMID:22984576 PMID:27431321 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases expression
multiple interactions
EXP
ISO
Simazine results in decreased expression of NOS3 mRNA; Simazine results in decreased expression of NOS3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS3 protein]; U 0126 inhibits the reaction [Simazine results in decreased expression of NOS3 protein]
CTD PMID:22984576 PMID:27431321 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 affects expression
decreases expression
multiple interactions
increases expression
EXP
ISO
Simazine affects the expression of NR4A2 mRNA
Simazine results in decreased expression of NR4A2 mRNA; Simazine results in decreased expression of NR4A2 protein
LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of NR4A2 protein]
Simazine results in increased expression of NR4A2 mRNA; Simazine results in increased expression of NR4A2 protein
CTD PMID:27513680 PMID:29115391 PMID:32822773 PMID:34936186 NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases expression ISO Simazine results in increased expression of NR5A1 mRNA CTD PMID:17520059 NCBI chr 2:38,582,668...38,604,554
Ensembl chr 2:38,582,668...38,604,554
JBrowse link
G Odc1 ornithine decarboxylase, structural 1 decreases expression ISO Simazine results in decreased expression of ODC1 mRNA CTD PMID:15519604 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506
JBrowse link
G Pde4a phosphodiesterase 4A, cAMP specific decreases activity ISO Simazine results in decreased activity of PDE4A protein CTD PMID:21251949 NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,073,005...21,124,544
JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific affects activity ISO Simazine affects the activity of PDE5 protein CTD PMID:21251949 NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Simazine inhibits the reaction [Progesterone binds to PGR protein] CTD PMID:8812239 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612
JBrowse link
G Pitx3 paired-like homeodomain transcription factor 3 increases expression
multiple interactions
decreases expression
EXP Simazine results in increased expression of PITX3 mRNA; Simazine results in increased expression of PITX3 protein
LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of PITX3 protein]
Simazine results in decreased expression of PITX3 mRNA; Simazine results in decreased expression of PITX3 protein
CTD PMID:32822773 PMID:34936186 NCBI chr19:46,123,720...46,136,764
Ensembl chr19:46,124,124...46,136,765
JBrowse link
G Plcz1 phospholipase C, zeta 1 increases expression EXP Simazine results in increased expression of PLCZ1 mRNA CTD PMID:22984576 NCBI chr 6:139,933,118...139,987,188
Ensembl chr 6:139,935,399...139,987,183
JBrowse link
G Pomc pro-opiomelanocortin-alpha increases secretion ISO Simazine results in increased secretion of POMC protein modified form CTD PMID:19690231 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642
JBrowse link
G Prl prolactin increases expression ISO Simazine results in increased expression of PRL protein CTD PMID:11071396 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
G Rasal2 RAS protein activator like 2 increases expression EXP Simazine results in increased expression of RASAL2 mRNA CTD PMID:22984576 NCBI chr 1:156,962,759...157,240,170
Ensembl chr 1:156,962,752...157,240,165
JBrowse link
G Rln1 relaxin 1 multiple interactions ISO Simazine inhibits the reaction [RLN1 protein binds to RXFP1 protein] CTD PMID:27431321 NCBI chr19:29,309,155...29,312,070
Ensembl chr19:29,308,570...29,312,070
JBrowse link
G Rxfp1 relaxin/insulin-like family peptide receptor 1 decreases expression
multiple interactions
EXP
ISO
Simazine results in decreased expression of RXFP1 mRNA; Simazine results in decreased expression of RXFP1 protein
Simazine inhibits the reaction [RLN1 protein binds to RXFP1 protein]
CTD PMID:22984576 PMID:27431321 NCBI chr 3:79,548,910...79,645,258
Ensembl chr 3:79,548,918...79,645,187
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 affects expression
decreases expression
EXP
ISO
Simazine affects the expression of SLC18A2 mRNA; Simazine affects the expression of SLC18A2 protein
Simazine results in decreased expression of SLC18A2 mRNA; Simazine results in decreased expression of SLC18A2 protein
CTD PMID:29115391 PMID:29137186 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 decreases expression
affects expression
ISO
EXP
Simazine results in decreased expression of SLC6A3 mRNA; Simazine results in decreased expression of SLC6A3 protein
Simazine affects the expression of SLC6A3 mRNA; Simazine affects the expression of SLC6A3 protein
CTD PMID:29115391 PMID:29137186 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link
G Spag6 sperm associated antigen 6 decreases expression EXP Simazine results in decreased expression of SPAG6 mRNA CTD PMID:22984576 NCBI chr 2:18,698,808...18,754,561
Ensembl chr 2:18,698,843...18,755,224
JBrowse link
G Tas2r129 taste receptor, type 2, member 129 decreases expression EXP Simazine results in decreased expression of TAS2R129 mRNA CTD PMID:22984576 NCBI chr 6:132,928,065...132,929,027
Ensembl chr 6:132,928,065...132,929,029
JBrowse link
G Th tyrosine hydroxylase decreases expression
increases expression
affects expression
multiple interactions
ISO
EXP
Simazine results in decreased expression of TH protein
Simazine results in increased expression of TH mRNA; Simazine results in increased expression of TH protein
Simazine affects the expression of TH mRNA; Simazine affects the expression of TH protein
LMX1A protein promotes the reaction [Simazine results in increased expression of TH protein]
Simazine results in decreased expression of TH mRNA; Simazine results in decreased expression of TH protein
CTD PMID:14550852 PMID:27513680 PMID:29137186 PMID:32822773 PMID:34936186 NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
Simazine results in decreased expression of TNF protein
Simazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:10883730 PMID:15256756 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tssk1 testis-specific serine kinase 1 decreases expression EXP Simazine results in decreased expression of TSSK1 mRNA CTD PMID:22984576 NCBI chr16:17,712,067...17,713,517
Ensembl chr16:17,712,087...17,715,786
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Simazine results in decreased expression of VEGFA mRNA CTD PMID:22984576 PMID:27431321 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Wnt1 wingless-type MMTV integration site family, member 1 increases expression
multiple interactions
decreases expression
EXP Simazine results in increased expression of WNT1 mRNA; Simazine results in increased expression of WNT1 protein
LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 mRNA]; LMX1A protein promotes the reaction [Simazine results in increased expression of WNT1 protein]
Simazine results in decreased expression of WNT1 mRNA; Simazine results in decreased expression of WNT1 protein
CTD PMID:27513680 PMID:32822773 PMID:34936186 NCBI chr15:98,687,738...98,691,711
Ensembl chr15:98,687,738...98,691,718
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      biological role 22166
        xenobiotic 19678
          simazine 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    main group molecular entity 22108
                      s-block molecular entity 21708
                        hydrogen molecular entity 21626
                          hydrides 20762
                            inorganic hydride 18674
                              pnictogen hydride 18654
                                nitrogen hydride 18521
                                  azane 18428
                                    ammonia 18427
                                      organic amino compound 18427
                                        polyamine 8961
                                          diamine 8898
                                            diamino-1,3,5-triazine 5034
                                              simazine 57
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