Mos (Moloney sarcoma oncogene) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mos (Moloney sarcoma oncogene) Mus musculus
Analyze
Symbol: Mos
Name: Moloney sarcoma oncogene
RGD ID: 10910
MGI Page MGI
Description: Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of metaphase/anaphase transition of meiotic cell cycle; and positive regulation of MAPK cascade. Acts upstream of or within regulation of meiotic nuclear division. Located in cytoplasm. Is expressed in brain; early conceptus; gonad; large intestine; and metanephros. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-m; c-mos; c-mos proto-oncogene; oocyte maturation factor mos; proto-oncogene c-Mos; proto-oncogene serine/threonine-protein kinase mos
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,870,658 - 3,872,105 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm39 Ensembl
GRCm3843,870,658 - 3,872,105 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm38mm10GRCm38
MGSCv3743,797,805 - 3,799,252 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,797,930 - 3,799,104 (-)NCBIMGSCv36mm8
Celera43,827,056 - 3,828,607 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1311971   PMID:1315307   PMID:1351769   PMID:1421760   PMID:1461652   PMID:1508191   PMID:1639403   PMID:1684952   PMID:1685142   PMID:1833718   PMID:2165966   PMID:2166832  
PMID:2341157   PMID:2568329   PMID:2570024   PMID:2574141   PMID:2906048   PMID:3028423   PMID:4000280   PMID:6096859   PMID:6173134   PMID:6190012   PMID:6243788   PMID:6251463  
PMID:6256659   PMID:6283546   PMID:6292737   PMID:6300424   PMID:6316344   PMID:6594688   PMID:7143580   PMID:7233190   PMID:7622418   PMID:7684693   PMID:7724579   PMID:7736667  
PMID:7752808   PMID:7774913   PMID:7813775   PMID:7821612   PMID:7838525   PMID:7848911   PMID:7949731   PMID:7956345   PMID:8015609   PMID:8015610   PMID:8069308   PMID:8188294  
PMID:8276397   PMID:8369223   PMID:8480178   PMID:8541219   PMID:8622874   PMID:8631259   PMID:8692939   PMID:8790740   PMID:8825643   PMID:8835542   PMID:8858597   PMID:8864742  
PMID:8891345   PMID:8903793   PMID:8949889   PMID:9008414   PMID:9013780   PMID:9321476   PMID:9322252   PMID:9362468   PMID:9464852   PMID:9590541   PMID:10349636   PMID:10655585  
PMID:10725249   PMID:10922068   PMID:10954860   PMID:11042159   PMID:11069114   PMID:11076861   PMID:11080153   PMID:11180847   PMID:11217851   PMID:11319135   PMID:12021186   PMID:12112586  
PMID:12207927   PMID:12426378   PMID:12466851   PMID:12477932   PMID:12663500   PMID:14594209   PMID:15188402   PMID:15326356   PMID:15837801   PMID:15970507   PMID:16141072   PMID:16141073  
PMID:16690745   PMID:16964442   PMID:17369397   PMID:17827876   PMID:18097537   PMID:18550795   PMID:20724447   PMID:21267068   PMID:21460039   PMID:21677750   PMID:21873635   PMID:23851486  
PMID:24194600   PMID:24357321   PMID:24920040   PMID:25597399   PMID:34293340   PMID:35104175  


Genomics

Comparative Map Data
Mos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,870,658 - 3,872,105 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm39 Ensembl
GRCm3843,870,658 - 3,872,105 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm38mm10GRCm38
MGSCv3743,797,805 - 3,799,252 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,797,930 - 3,799,104 (-)NCBIMGSCv36mm8
Celera43,827,056 - 3,828,607 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.16NCBI
MOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,112,942 - 56,113,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl856,112,942 - 56,113,982 (-)EnsemblGRCh38hg38GRCh38
GRCh37857,025,501 - 57,026,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,188,055 - 57,189,095 (-)NCBINCBI36Build 36hg18NCBI36
Build 34857,188,054 - 57,189,095NCBI
Celera853,016,252 - 53,017,292 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,492,986 - 52,494,026 (-)NCBIHuRef
CHM1_1857,077,104 - 57,078,144 (-)NCBICHM1_1
T2T-CHM13v2.0856,489,918 - 56,490,958 (-)NCBIT2T-CHM13v2.0
Mos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8521,657,549 - 21,658,856 (-)NCBIGRCr8
mRatBN7.2516,859,957 - 16,861,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,859,957 - 16,861,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,101,026 - 19,102,333 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0520,699,515 - 20,700,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0520,451,008 - 20,452,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0516,746,085 - 16,747,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,746,197 - 16,747,222 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,526,047 - 21,527,345 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,158,906 - 17,160,204 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,157,660 - 17,160,891 (-)NCBI
Celera516,224,269 - 16,225,576 (-)NCBICelera
Cytogenetic Map5q12NCBI
Mos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545415,193,132 - 15,194,268 (-)NCBIChiLan1.0ChiLan1.0
MOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2771,770,387 - 71,771,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1847,494,891 - 47,496,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0852,559,066 - 52,560,362 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1849,930,077 - 49,931,117 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl849,930,077 - 49,931,117 (-)Ensemblpanpan1.1panPan2
MOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,510,987 - 7,513,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,823,723 - 7,826,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,585,329 - 7,589,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl297,585,443 - 7,586,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1297,599,834 - 7,602,449 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,731,622 - 7,735,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,008,489 - 8,012,354 (-)NCBIUU_Cfam_GSD_1.0
Mos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530372,020,606 - 72,021,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364962,763,822 - 2,764,871 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364962,763,822 - 2,764,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,739,402 - 75,741,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,739,402 - 75,741,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,657,132 - 82,658,806 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,150,113 - 52,152,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,150,237 - 52,151,274 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,647,409 - 89,648,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248863,934,192 - 3,935,220 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248863,934,081 - 3,935,341 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mos
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:52
Interacting mature miRNAs:52
Transcripts:ENSMUST00000105158
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11049579Lmr9b_mleishmaniasis resistance 9b (mouse)4120657234Mouse
11049580Lmr9a_mleishmaniasis resistance 9 (mouse)4120657234Mouse
1301274Lmr9_mleishmaniasis resistance 9 (mouse)Not determined4120657234Mouse
10412079Sm1_msusceptibility to Schistosoma mansoni infection 1 (mouse)Not determined4122955614Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse

Markers in Region
UniSTS:234860  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3843,870,773 - 3,870,968UniSTSGRCm38
MGSCv3743,797,920 - 3,798,115UniSTSGRCm37
Celera43,827,171 - 3,827,366UniSTS
Cytogenetic Map4A1-A2UniSTS
Mos  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3843,870,803 - 3,871,669UniSTSGRCm38
MGSCv3743,797,950 - 3,798,816UniSTSGRCm37
Celera43,827,201 - 3,828,171UniSTS
Cytogenetic Map4A1-A2UniSTS
cM Map4 UniSTS
UniSTS:492607  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3843,870,699 - 3,872,019UniSTSGRCm38
MGSCv3743,797,846 - 3,799,166UniSTSGRCm37
Celera43,827,097 - 3,828,521UniSTS
Cytogenetic Map4A1-A2UniSTS
Mos  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3843,870,690 - 3,871,034UniSTSGRCm38
MGSCv3743,797,837 - 3,798,181UniSTSGRCm37
Celera43,827,088 - 3,827,432UniSTS
Cytogenetic Map4A1-A2UniSTS
cM Map4 UniSTS
Mos  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3843,871,036 - 3,871,535UniSTSGRCm38
MGSCv3743,798,183 - 3,798,682UniSTSGRCm37
Celera43,827,434 - 3,828,037UniSTS
Cytogenetic Map4A1-A2UniSTS
Mos  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3843,871,344 - 3,871,657UniSTSGRCm38
MGSCv3743,798,491 - 3,798,804UniSTSGRCm37
Celera43,827,846 - 3,828,159UniSTS
Cytogenetic Map4A1-A2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000105158   ⟹   ENSMUSP00000100789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl43,870,657 - 3,872,105 (-)Ensembl
GRCm38.p6 Ensembl43,870,657 - 3,872,105 (-)Ensembl
RefSeq Acc Id: NM_020021   ⟹   NP_064405
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3943,870,658 - 3,872,105 (-)NCBI
GRCm3843,870,658 - 3,872,105 (-)ENTREZGENE
MGSCv3743,797,805 - 3,799,252 (-)RGD
Celera43,827,056 - 3,828,607 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_064405 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB59724 (Get FASTA)   NCBI Sequence Viewer  
  AAB59725 (Get FASTA)   NCBI Sequence Viewer  
  AAI37691 (Get FASTA)   NCBI Sequence Viewer  
  AAI45746 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100789
  ENSMUSP00000100789.2
GenBank Protein P00536 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_064405   ⟸   NM_020021
- UniProtKB: Q61887 (UniProtKB/Swiss-Prot),   Q61886 (UniProtKB/Swiss-Prot),   P00536 (UniProtKB/Swiss-Prot),   E9PV67 (UniProtKB/Swiss-Prot),   Q78EH5 (UniProtKB/Swiss-Prot),   F6UHW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000100789   ⟸   ENSMUST00000105158
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00536-F1-model_v2 AlphaFold P00536 1-343 view protein structure

Promoters
RGD ID:6850228
Promoter ID:EP29022
Type:multiple initiation site
Name:MM_MOS_2
Description:Cellular-Moloney murine sarcoma virus oncogene ovary
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #2 of 2; 5' exon 1; site 2.; see alsoEP29021  
Tissues & Cell Lines:ovary
Experiment Methods:Nuclease protection; Primer extension
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3743,799,033 - 3,799,093EPD
MGSCv3643,799,033 - 3,799,093EPD
RGD ID:6850226
Promoter ID:EP29021
Type:initiation region
Name:MM_MOS_1
Description:Cellular-Moloney murine sarcoma virus oncogene testis
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:alternative promoter #1 of 2; 5' exon 1; site 1.; see alsoEP29022  
Tissues & Cell Lines:testis; spermatids
Experiment Methods:Nuclease protection; low-precision data; Primer extension; low-precision data; [1].
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3743,799,247 - 3,799,307EPD
MGSCv3643,799,247 - 3,799,307EPD
RGD ID:6882732
Promoter ID:EPDNEW_M4816
Type:single initiation site
Name:MOS_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4817  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3843,871,886 - 3,871,946EPDNEW
RGD ID:6882734
Promoter ID:EPDNEW_M4817
Type:preliminary
Name:MOS_2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4816  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3843,872,100 - 3,872,160EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97052 AgrOrtholog
Ensembl Genes ENSMUSG00000028235
  ENSMUSG00000078365 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000105158 ENTREZGENE
  ENSMUST00000105158.2 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:17451 UniProtKB/Swiss-Prot
MGD MGI:97052 ENTREZGENE
NCBI Gene 17451 ENTREZGENE
PANTHER PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS UniProtKB/Swiss-Prot
  SERINE-THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Mos PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt E9PV67 ENTREZGENE
  F6UHW1 ENTREZGENE
  MOS_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q61886 ENTREZGENE
  Q61887 ENTREZGENE
  Q78EH5 ENTREZGENE
UniProt Secondary E9PV67 UniProtKB/Swiss-Prot
  F6UHW1 UniProtKB/Swiss-Prot
  Q61886 UniProtKB/Swiss-Prot
  Q61887 UniProtKB/Swiss-Prot
  Q78EH5 UniProtKB/Swiss-Prot