Mos (MOS proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Mos (MOS proto-oncogene, serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Mos
Name: MOS proto-oncogene, serine/threonine kinase
RGD ID: 3103
Description: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including ERK1 and ERK2 cascade; microtubule cytoskeleton organization; and negative regulation of metaphase/anaphase transition of meiotic cell cycle. Predicted to act upstream of or within regulation of meiotic nuclear division. Located in cytosol. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-mos; Moloney murine sarcoma viral (v-mos) oncogene homolog; Moloney sarcoma oncogene; oocyte maturation factor mos; proto-oncogene c-Mos; proto-oncogene serine/threonine-protein kinase mos; v-mos moloney murine sarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2516,859,957 - 16,861,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,859,957 - 16,861,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,101,026 - 19,102,333 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0520,699,515 - 20,700,822 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0520,451,008 - 20,452,315 (-)NCBIRnor_WKY
Rnor_6.0516,746,085 - 16,747,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,746,197 - 16,747,222 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,526,047 - 21,527,345 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,158,906 - 17,160,204 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,157,660 - 17,160,891 (-)NCBI
Celera516,224,269 - 16,225,576 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
4. cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes. Lazar S, etal., Mol Endocrinol 2002 Feb;16(2):331-41.
5. Rat myogenic c-mos cDNA: cloning sequence analysis and regulation during muscle development. Leibovitch SA, etal., Oncogene 1990 Aug;5(8):1149-57.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Definitive expression of c-mos in late meiotic prophase leads to phosphorylation of a 34 kda protein in cultured rat spermatocytes. Nagao Y Cell Biol Int 2002;26(2):193-201.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Complete c-mos (rat) nucleotide sequence: presence of conserved domains in c-mos proteins. van der Hoorn FA and Firzlaff J, Nucleic Acids Res 1984 Feb 24;12(4):2147-56.
13. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
Additional References at PubMed
PMID:1298984   PMID:8015609   PMID:8015610   PMID:8631259   PMID:8692939   PMID:12207927   PMID:12533425   PMID:19550110   PMID:19802389   PMID:20724447  


Genomics

Comparative Map Data
Mos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2516,859,957 - 16,861,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,859,957 - 16,861,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,101,026 - 19,102,333 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0520,699,515 - 20,700,822 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0520,451,008 - 20,452,315 (-)NCBIRnor_WKY
Rnor_6.0516,746,085 - 16,747,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,746,197 - 16,747,222 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,526,047 - 21,527,345 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,158,906 - 17,160,204 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,157,660 - 17,160,891 (-)NCBI
Celera516,224,269 - 16,225,576 (-)NCBICelera
Cytogenetic Map5q12NCBI
MOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,112,942 - 56,113,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl856,112,942 - 56,113,982 (-)EnsemblGRCh38hg38GRCh38
GRCh37857,025,501 - 57,026,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,188,055 - 57,189,095 (-)NCBINCBI36Build 36hg18NCBI36
Build 34857,188,054 - 57,189,095NCBI
Celera853,016,252 - 53,017,292 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,492,986 - 52,494,026 (-)NCBIHuRef
CHM1_1857,077,104 - 57,078,144 (-)NCBICHM1_1
T2T-CHM13v2.0856,489,918 - 56,490,958 (-)NCBIT2T-CHM13v2.0
Mos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,870,658 - 3,872,105 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm39 Ensembl
GRCm3843,870,658 - 3,872,105 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm38mm10GRCm38
MGSCv3743,797,805 - 3,799,252 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,797,930 - 3,799,104 (-)NCBIMGSCv36mm8
Celera43,827,056 - 3,828,607 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.16NCBI
Mos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545415,193,132 - 15,194,268 (-)NCBIChiLan1.0ChiLan1.0
MOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1849,930,077 - 49,931,117 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl849,930,077 - 49,931,117 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0852,559,066 - 52,560,362 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,510,987 - 7,513,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,823,723 - 7,826,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,585,329 - 7,589,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl297,585,443 - 7,586,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1297,599,834 - 7,602,449 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,731,622 - 7,735,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,008,489 - 8,012,354 (-)NCBIUU_Cfam_GSD_1.0
Mos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530372,020,606 - 72,021,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364962,763,822 - 2,764,871 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364962,763,822 - 2,764,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,739,402 - 75,741,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,739,402 - 75,741,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,657,132 - 82,658,806 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,150,113 - 52,152,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,150,237 - 52,151,274 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,647,409 - 89,648,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248863,934,192 - 3,935,220 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248863,934,081 - 3,935,341 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mos
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:130
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000011602
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 9 12 25 1
Below cutoff 35 20 16 5 16 5 6 61 12 14 10 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011602   ⟹   ENSRNOP00000064243
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl516,859,957 - 16,861,264 (-)Ensembl
Rnor_6.0 Ensembl516,746,197 - 16,747,222 (-)Ensembl
RefSeq Acc Id: NM_020102   ⟹   NP_064487
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,859,957 - 16,861,264 (-)NCBI
Rnor_6.0516,746,085 - 16,747,392 (-)NCBI
Rnor_5.0521,526,047 - 21,527,345 (-)NCBI
RGSC_v3.4517,158,906 - 17,160,204 (-)RGD
Celera516,224,269 - 16,225,576 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_064487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA25123 (Get FASTA)   NCBI Sequence Viewer  
  CAA37128 (Get FASTA)   NCBI Sequence Viewer  
  EDM11614 (Get FASTA)   NCBI Sequence Viewer  
  P00539 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_064487   ⟸   NM_020102
- UniProtKB: M0R4F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064243   ⟸   ENSRNOT00000011602
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00539-F1-model_v2 AlphaFold P00539 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3103 AgrOrtholog
BioCyc Gene G2FUF-42115 BioCyc
Ensembl Genes ENSRNOG00000008567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064243 ENTREZGENE
  ENSRNOP00000064243.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011602 ENTREZGENE
  ENSRNOT00000011602.6 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24559 UniProtKB/TrEMBL
NCBI Gene 24559 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mos PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M0R4F9 ENTREZGENE, UniProtKB/TrEMBL
  MOS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Mos  MOS proto-oncogene, serine/threonine kinase  Mos  Moloney sarcoma oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Mos  Moloney sarcoma oncogene  Mos  v-mos moloney murine sarcoma viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mos  v-mos moloney murine sarcoma viral oncogene homolog      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Mos  v-mos moloney murine sarcoma viral oncogene homolog      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression highest in skeletal muscle, heart, and brain; expression in cardiac ventricle increases after birth 70317
gene_function phosphorylates and activates Map2k1 70317
gene_product mitogen activated protein kinase kinase kinase 70317
gene_protein 43 kDa 70317