MOS (MOS proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: MOS (MOS proto-oncogene, serine/threonine kinase) Sus scrofa
Analyze
Symbol: MOS
Name: MOS proto-oncogene, serine/threonine kinase
RGD ID: 14094512
Description: ENCODES a protein that exhibits MAP kinase kinase kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN ERK1 and ERK2 cascade; MAPK cascade; negative regulation of metaphase/anaphase transition of meiotic cell cycle; ASSOCIATED WITH genetic disease (ortholog); Oocyte/Zygote/Embryo Maturation Arrest 20 (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: c-mos; oocyte maturation factor mos; p39-mos; proto-oncogene c-Mos; proto-oncogene serine/threonine-protein kinase mos; v-mos Moloney murine sarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,739,402 - 75,741,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,739,402 - 75,741,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,657,132 - 82,658,806 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (ISS)

References
Additional References at PubMed
PMID:8858597   PMID:12533425   PMID:15987821   PMID:19550110   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,739,402 - 75,741,076 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,739,402 - 75,741,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,657,132 - 82,658,806 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,112,942 - 56,113,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl856,112,942 - 56,113,982 (-)EnsemblGRCh38hg38GRCh38
GRCh37857,025,501 - 57,026,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,188,055 - 57,189,095 (-)NCBINCBI36Build 36hg18NCBI36
Build 34857,188,054 - 57,189,095NCBI
Celera853,016,252 - 53,017,292 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,492,986 - 52,494,026 (-)NCBIHuRef
CHM1_1857,077,104 - 57,078,144 (-)NCBICHM1_1
T2T-CHM13v2.0856,489,918 - 56,490,958 (-)NCBIT2T-CHM13v2.0
Mos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,870,658 - 3,872,105 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm39 Ensembl
GRCm3843,870,658 - 3,872,105 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,870,657 - 3,872,105 (-)EnsemblGRCm38mm10GRCm38
MGSCv3743,797,805 - 3,799,252 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,797,930 - 3,799,104 (-)NCBIMGSCv36mm8
Celera43,827,056 - 3,828,607 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.16NCBI
Mos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8521,657,549 - 21,658,856 (-)NCBIGRCr8
mRatBN7.2516,859,957 - 16,861,264 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,859,957 - 16,861,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,101,026 - 19,102,333 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0520,699,515 - 20,700,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0520,451,008 - 20,452,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0516,746,085 - 16,747,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,746,197 - 16,747,222 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,526,047 - 21,527,345 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,158,906 - 17,160,204 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,157,660 - 17,160,891 (-)NCBI
Celera516,224,269 - 16,225,576 (-)NCBICelera
Cytogenetic Map5q12NCBI
Mos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545415,193,132 - 15,194,268 (-)NCBIChiLan1.0ChiLan1.0
MOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2771,770,387 - 71,771,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1847,494,891 - 47,496,185 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0852,559,066 - 52,560,362 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1849,930,077 - 49,931,117 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl849,930,077 - 49,931,117 (-)Ensemblpanpan1.1panPan2
MOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,510,987 - 7,513,180 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,823,723 - 7,826,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,585,329 - 7,589,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl297,585,443 - 7,586,489 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1297,599,834 - 7,602,449 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,731,622 - 7,735,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,008,489 - 8,012,354 (-)NCBIUU_Cfam_GSD_1.0
Mos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530372,020,606 - 72,021,655 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364962,763,822 - 2,764,871 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364962,763,822 - 2,764,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,150,113 - 52,152,390 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,150,237 - 52,151,274 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,647,409 - 89,648,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248863,934,192 - 3,935,220 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248863,934,081 - 3,935,341 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MOS
36 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system
High
Medium
Low 1 1 9
Below cutoff 3 1 2 2 1 12 1 1

Sequence


RefSeq Acc Id: ENSSSCT00000006847   ⟹   ENSSSCP00000006661
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl475,739,402 - 75,741,076 (+)Ensembl
RefSeq Acc Id: NM_001113219   ⟹   NP_001106690
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1475,739,402 - 75,741,076 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001106690   ⟸   NM_001113219
- UniProtKB: P50118 (UniProtKB/Swiss-Prot),   A0A8D1JQ05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000006661   ⟸   ENSSSCT00000006847
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006248 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005011465 UniProtKB/Swiss-Prot
  ENSSSCG00015062389 UniProtKB/Swiss-Prot
  ENSSSCG00025021845 UniProtKB/Swiss-Prot
  ENSSSCG00030042704 UniProtKB/Swiss-Prot
  ENSSSCG00035041576 UniProtKB/Swiss-Prot
  ENSSSCG00040023423 UniProtKB/Swiss-Prot
  ENSSSCG00045019514 UniProtKB/Swiss-Prot
  ENSSSCG00050007929 UniProtKB/TrEMBL
  ENSSSCG00055025768 UniProtKB/Swiss-Prot
  ENSSSCG00060063857 UniProtKB/Swiss-Prot
  ENSSSCG00065079211 UniProtKB/Swiss-Prot
  ENSSSCG00070004101 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000006847 ENTREZGENE
  ENSSSCT00000006847.2 UniProtKB/Swiss-Prot
  ENSSSCT00005017682.1 UniProtKB/Swiss-Prot
  ENSSSCT00015083319.1 UniProtKB/Swiss-Prot
  ENSSSCT00025029719.1 UniProtKB/Swiss-Prot
  ENSSSCT00030059487.1 UniProtKB/Swiss-Prot
  ENSSSCT00035055230.1 UniProtKB/Swiss-Prot
  ENSSSCT00040031368.1 UniProtKB/Swiss-Prot
  ENSSSCT00045033223.1 UniProtKB/Swiss-Prot
  ENSSSCT00050010810.1 UniProtKB/TrEMBL
  ENSSSCT00055050924.1 UniProtKB/Swiss-Prot
  ENSSSCT00060087118.1 UniProtKB/Swiss-Prot
  ENSSSCT00065110114.1 UniProtKB/Swiss-Prot
  ENSSSCT00070007703.1 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100127484 UniProtKB/Swiss-Prot
NCBI Gene MOS ENTREZGENE
PANTHER PROTO-ONCOGENE SERINE_THREONINE-PROTEIN KINASE MOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Integrin-linked_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A8D1JQ05 ENTREZGENE, UniProtKB/TrEMBL
  MOS_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:90312 ENTREZGENE