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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11414
Species: Mus musculus
RGD Object: Gene
Symbol: Th
Name: tyrosine hydroxylase
Acc ID: CHEBI:27496
Term: simazine
Definition: A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.
Chemical ID: MESH:D012839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thaffects expressionEXP 6480464CTDSimazine affects the expression of TH mRNA; Simazine affects the expression of TH proteinPMID:29137186
Thdecreases expressionEXP 6480464CTDSimazine results in decreased expression of TH mRNA; Simazine results in decreased expression of TH proteinPMID:34936186
Thincreases expressionEXP 6480464CTDSimazine results in increased expression of TH mRNA; Simazine results in increased expression of TH proteinPMID:27513680 PMID:32822773
Thmultiple interactionsEXP 6480464CTDLMX1A protein promotes the reaction [Simazine results in increased expression of TH protein]PMID:32822773
Thdecreases expressionISOTh (Rattus norvegicus)6480464CTDSimazine results in decreased expression of TH proteinPMID:14550852
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