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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:pyruvate metabolic pathway
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Accession:PW:0000043 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis, utilization and/or degradation of pyruvate - a salt, ester, or anionic form of pyruvic acid. Pyruvate, which is the end-product of glycolysis, can be converted to lactate under anaerobic conditions, can be further oxidized via the Krebs or citrate cycle or can be converted back to glucose via gluconeogenesis.
Synonyms:related_synonym: Pyruvate metabolism;   pyruvate metabolic process
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pyruvate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acacb acetyl-CoA carboxylase beta IEA KEGG rno:00620 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:48,026,394...48,138,214 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 IEA KEGG rno:00620 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Acot12 acyl-CoA thioesterase 12 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 2:24,721,648...24,763,686
Ensembl chr 2:24,721,910...24,765,298 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 IEA KEGG rno:00620 NCBI chr 3:159,910,809...159,960,748
Ensembl chr 3:159,910,809...159,960,748 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:164,464,055...164,519,830 		JBrowse link
G Acyp1 acylphosphatase 1 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 6:110,650,213...110,663,404
Ensembl chr 6:110,650,213...110,663,612 		JBrowse link
G Acyp2 acylphosphatase 2 IEA KEGG rno:00620 NCBI chr14:108,402,837...108,572,367
Ensembl chr14:108,402,544...108,633,318 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IEA KEGG rno:00620 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 IEA KEGG rno:00620 NCBI chr 1:227,627,977...227,667,877
Ensembl chr 1:227,627,448...227,672,523 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 IEA KEGG rno:00620 NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:64,858,934...64,864,365 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 IEA KEGG rno:00620 NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 IEA KEGG rno:00620 NCBI chr18:52,208,035...52,240,293
Ensembl chr18:52,204,161...52,240,467 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 IEA KEGG rno:00620 NCBI chr13:82,038,679...82,055,478
Ensembl chr13:82,038,533...82,055,481 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase ISO
IEA 		KEGG
SMPDB
RGD		 PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:59,868,214...59,900,818
Ensembl chr 1:59,868,214...59,900,818 		JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO
IEA 		KEGG
SMPDB
RGD		 PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:53,619,631...53,652,354 		JBrowse link
G Glo1 glyoxalase 1 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191 		JBrowse link
G Grhpr glyoxylate and hydroxypyruvate reductase ISO SMPDB SMP:00060 NCBI chr 5:64,029,856...64,039,287
Ensembl chr 5:64,022,368...64,039,276 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr10:14,379,400...14,394,046
Ensembl chr10:14,382,410...14,394,043 		JBrowse link
G Ldha lactate dehydrogenase A IEA KEGG rno:00620 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Ldhal1 lactate dehydrogenase A like 1 IEA KEGG rno:00620 NCBI chr 8:38,621,351...38,622,975 JBrowse link
G Ldhal6b lactate dehydrogenase A-like 6B IEA KEGG rno:00620 NCBI chr 1:48,402,997...48,404,420
Ensembl chr 1:48,403,012...48,404,851 		JBrowse link
G Ldhb lactate dehydrogenase B IEA KEGG rno:00620 NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408 		JBrowse link
G Ldhc lactate dehydrogenase C IEA KEGG rno:00620 NCBI chr 1:106,522,140...106,539,649
Ensembl chr 1:106,522,236...106,542,802 		JBrowse link
G Ldhd lactate dehydrogenase D IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr19:56,492,827...56,497,695
Ensembl chr19:56,482,924...56,509,197 		JBrowse link
G Mdh1 malate dehydrogenase 1 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:99,831,615...99,847,232 		JBrowse link
G Mdh2 malate dehydrogenase 2 IEA KEGG rno:00620 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:26,530,881...26,543,841 		JBrowse link
G Me1 malic enzyme 1 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275 		JBrowse link
G Me2 malic enzyme 2 IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr18:69,626,073...69,676,218
Ensembl chr18:69,626,087...69,676,218 		JBrowse link
G Me3 malic enzyme 3 IEA KEGG rno:00620 NCBI chr 1:152,946,595...153,148,026
Ensembl chr 1:152,946,628...153,148,026 		JBrowse link
G Pc pyruvate carboxylase IEA
ISO 		KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEA
ISO 		KEGG lists it, no info KEGG
SMPDB		 SMP:00060 rno:00620 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IEA KEGG rno:00620 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 IEA
ISO 		KEGG lists it but there is info KEGG
SMPDB
RGD		 PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:38,509,084...38,522,536 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 IEA
ISO 		KEGG
RGD		 PMID:11795479 rno:00620, RGD:2307427 NCBI chr 2:232,545,550...232,547,098
Ensembl chr 2:232,415,088...232,549,624 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta ISO
IEA 		KEGG
SMPDB
RGD		 PMID:11795479 SMP:00060 rno:00620, RGD:2307427 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:19,181,208...19,188,976 		JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X ISO RGD PMID:11795479 RGD:2307427 NCBI chr 3:109,826,579...109,886,869
Ensembl chr 3:109,827,209...109,886,905 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr  X:62,480,535...62,547,371
Ensembl chr  X:62,480,535...62,547,371 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 ISO RGD PMID:11795479 PMID:17310282 RGD:2307427, RGD:2307428 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 ISO RGD PMID:17310282 RGD:2307428 NCBI chr 5:30,245,699...30,252,494
Ensembl chr 5:30,242,704...30,253,960 		JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 ISO RGD PMID:17310282 RGD:2307428 NCBI chr19:392,858...400,529
Ensembl chr19:392,183...400,902 		JBrowse link
G Pklr pyruvate kinase L/R IEA
IDA
ISO 		KEGG
SMPDB
RGD		 PMID:4273555 SMP:00060 rno:00620, RGD:2302790 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644 		JBrowse link
G Pkm pyruvate kinase M1/2 IDA RGD PMID:4273555 RGD:2302790 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1853
      carbohydrate metabolic pathway 526
        pyruvate metabolic pathway 48
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        organic chemical homeostasis pathway 767
          glucose homeostasis pathway 344
            glucose utilization pathway 121
              glucose oxidation pathway 100
                pyruvate metabolic pathway 48
paths to the root