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Gene: Dld (dihydrolipoamide dehydrogenase) Rattus norvegicus
Symbol: Dld
Name: dihydrolipoamide dehydrogenase
RGD ID: 735073
Description: Exhibits dihydrolipoyl dehydrogenase activity; lipoamide binding activity; and nucleotide binding activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Involved in aging; carboxylic acid metabolic process; and dihydrolipoamide metabolic process. Localizes to mitochondrion; oxoglutarate dehydrogenase complex; and pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; INTERACTS WITH (R)-lipoic acid; 1,3-dinitrobenzene; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); dihydrolipoyl dehydrogenase, mitochondrial
Homo sapiens (human) : DLD (dihydrolipoamide dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Dld (dihydrolipoamide dehydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dld (dihydrolipoamide dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : DLD (dihydrolipoamide dehydrogenase)
Canis lupus familiaris (dog) : DLD (dihydrolipoamide dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dld (dihydrolipoamide dehydrogenase)
Sus scrofa (pig) : DLD (dihydrolipoamide dehydrogenase)
Chlorocebus sabaeus (African green monkey) : DLD (dihydrolipoamide dehydrogenase)
Heterocephalus glaber (naked mole-rat) : Dld (dihydrolipoamide dehydrogenase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0650,597,677 - 50,618,694 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl650,597,677 - 50,618,694 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,273,427 - 59,293,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4649,185,188 - 49,205,894 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1649,188,314 - 49,209,020 (-)NCBI
Celera647,106,161 - 47,126,575 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Dld
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735073
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.