Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Me2 (malic enzyme 2) Rattus norvegicus
Symbol: Me2
Name: malic enzyme 2
RGD ID: 1310321
Description: Predicted to have malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process; pyruvate metabolic process; and regulation of NADP metabolic process. Predicted to localize to mitochondrion. Orthologous to human ME2 (malic enzyme 2); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC307270; malic enzyme 2, NAD(+)-dependent, mitochondrial; NAD-dependent malic enzyme, mitochondrial
Homo sapiens (human) : ME2 (malic enzyme 2)  HGNC  Alliance
Mus musculus (house mouse) : Me2 (malic enzyme 2, NAD(+)-dependent, mitochondrial)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Me2 (malic enzyme 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ME2 (malic enzyme 2)
Canis lupus familiaris (dog) : ME2 (malic enzyme 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Me2 (malic enzyme 2)
Sus scrofa (pig) : ME2 (malic enzyme 2)
Chlorocebus sabaeus (African green monkey) : ME2 (malic enzyme 2)
Heterocephalus glaber (naked mole-rat) : Me2 (malic enzyme 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01869,737,515 - 69,784,099 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,738,686 - 69,784,099 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01868,882,367 - 68,927,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,545,530 - 70,590,828 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11870,619,765 - 70,655,815 (-)NCBI
Celera1865,538,881 - 65,583,847 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Me2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310321
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.