DRD2 (dopamine receptor D2) - Rat Genome Database
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Gene: DRD2 (dopamine receptor D2) Sus scrofa
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Symbol: DRD2
Name: dopamine receptor D2
RGD ID: 13920827
Description: ENCODES a protein that exhibits drug binding (ortholog); ionotropic glutamate receptor binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN acid secretion (ortholog); activation of protein kinase activity (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; ASSOCIATED WITH Alcoholic Intoxication (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN acrosomal vesicle (ortholog); axon terminus (ortholog); cilium (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D(2) dopamine receptor
Orthologs:
Homo sapiens (human) : DRD2 (dopamine receptor D2)  HGNC  Alliance
Mus musculus (house mouse) : Drd2 (dopamine receptor D2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Drd2 (dopamine receptor D2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd2 (dopamine receptor D2)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD2 (dopamine receptor D2)
Canis lupus familiaris (dog) : DRD2 (dopamine receptor D2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd2 (dopamine receptor D2)
Chlorocebus sabaeus (African green monkey) : DRD2 (dopamine receptor D2)
Heterocephalus glaber (naked mole-rat) : Drd2 (dopamine receptor D2)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,068,779 - 41,133,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,883,054 - 45,897,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
activation of protein kinase activity  (ISO)
adenohypophysis development  (IEA)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,IEA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
adult behavior  (ISO)
adult walking behavior  (IEA)
arachidonic acid secretion  (IEA)
associative learning  (ISO)
auditory behavior  (ISO)
autophagy  (ISO)
axonogenesis  (IEA)
behavioral response to cocaine  (IEA)
behavioral response to ethanol  (IEA)
branching morphogenesis of a nerve  (IEA)
cerebral cortex GABAergic interneuron migration  (IEA)
circadian regulation of gene expression  (IEA)
dopamine metabolic process  (IEA)
dopamine receptor signaling pathway  (ISO)
drinking behavior  (ISO)
feeding behavior  (IEA)
forebrain development  (ISO)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
grooming behavior  (IEA)
hyaloid vascular plexus regression  (IEA)
intracellular signal transduction  (ISO)
locomotory behavior  (ISO)
long-term memory  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of adenylate cyclase activity  (IBA)
negative regulation of blood pressure  (IEA)
negative regulation of cell death  (ISO)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of cytosolic calcium ion concentration  (IBA)
negative regulation of dopamine receptor signaling pathway  (IEA)
negative regulation of dopamine secretion  (ISO)
negative regulation of innate immune response  (IEA)
negative regulation of insulin secretion  (ISO)
negative regulation of protein kinase B signaling  (IEA)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein secretion  (IEA)
negative regulation of synaptic transmission  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IBA,IEA)
negative regulation of voltage-gated calcium channel activity  (IBA)
nervous system process involved in regulation of systemic arterial blood pressure  (IEA)
neuron-neuron synaptic transmission  (IEA)
orbitofrontal cortex development  (ISO)
peristalsis  (IEA)
phospholipase C-activating dopamine receptor signaling pathway  (IBA,IEA)
pigmentation  (IEA)
positive regulation of cytokinesis  (IEA)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA)
positive regulation of dopamine uptake involved in synaptic transmission  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glial cell-derived neurotrophic factor production  (IEA)
positive regulation of growth hormone secretion  (IEA)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of multicellular organism growth  (IEA)
positive regulation of neuroblast proliferation  (IEA)
positive regulation of neurogenesis  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of renal sodium excretion  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urine volume  (IEA)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (IEA,ISO)
protein localization  (IEA)
regulation of dopamine secretion  (IBA)
regulation of dopamine uptake involved in synaptic transmission  (ISO)
regulation of heart rate  (IEA)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of long-term neuronal synaptic plasticity  (IEA)
regulation of MAPK cascade  (ISO)
regulation of neurotransmitter uptake  (ISO)
regulation of phosphoprotein phosphatase activity  (ISO)
regulation of potassium ion transport  (IBA,IEA)
regulation of sodium ion transport  (IEA)
regulation of synapse structural plasticity  (ISO)
regulation of synaptic transmission, GABAergic  (IEA)
regulation of synaptic vesicle exocytosis  (IEA)
release of sequestered calcium ion into cytosol  (ISO)
response to amphetamine  (IEA)
response to axon injury  (ISO)
response to cocaine  (ISO)
response to drug  (IEA)
response to ethanol  (ISO)
response to histamine  (IEA)
response to hypoxia  (ISO)
response to inactivity  (ISO)
response to iron ion  (ISO)
response to light stimulus  (ISO)
response to morphine  (IEA)
response to nicotine  (ISO)
response to toxic substance  (ISO)
sensory perception of smell  (IEA)
startle response  (ISO)
striatum development  (ISO)
synapse assembly  (ISO)
synaptic transmission, dopaminergic  (IBA,IEA)
temperature homeostasis  (IEA)
visual learning  (IEA)
Wnt signaling pathway  (ISO)

References
Additional References at PubMed
PMID:18807216   PMID:22180074  


Genomics

Comparative Map Data
DRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,068,779 - 41,133,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,883,054 - 45,897,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11113,409,605 - 113,475,691 (-)EnsemblGRCh38hg38GRCh38
GRCh3811113,409,605 - 113,475,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711113,280,317 - 113,346,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,785,527 - 112,851,091 (-)NCBINCBI36hg18NCBI36
Build 3411112,785,527 - 112,851,103NCBI
Celera11110,433,249 - 110,498,937 (-)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11109,208,766 - 109,274,420 (-)NCBIHuRef
CHM1_111113,163,302 - 113,228,980 (-)NCBICHM1_1
Drd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,251,633 - 49,319,477 (+)NCBI
GRCm38949,340,360 - 49,408,177 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,340,627 - 49,408,177 (+)EnsemblGRCm38mm10GRCm38
MGSCv37949,148,767 - 49,215,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36949,092,857 - 49,160,407 (+)NCBImm8
Celera946,638,220 - 46,705,025 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.72NCBI
Drd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
Drd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,054,038 - 15,114,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,054,255 - 15,114,558 (-)NCBIChiLan1.0ChiLan1.0
DRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111112,132,703 - 112,168,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,132,703 - 112,198,935 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBIMhudiblu_PPA_v0panPan3
DRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1519,732,842 - 19,795,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Drd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1104,774,180 - 104,842,736 (-)Ensembl
ChlSab1.11104,774,632 - 104,843,417 (-)NCBI
Drd2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247848,828,589 - 8,906,617 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system musculoskeletal system nervous system reproductive system
High
Medium 1 2
Low 2 7
Below cutoff 1 1 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016414   ⟹   ENSSSCP00000015973
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl941,068,779 - 41,094,947 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000050179   ⟹   ENSSSCP00000053203
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl941,068,779 - 41,094,947 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000055534   ⟹   ENSSSCP00000049999
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl941,068,803 - 41,133,599 (-)Ensembl
RefSeq Acc Id: NM_001244253   ⟹   NP_001231182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1941,068,729 - 41,083,388 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021102111   ⟹   XP_020957770
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1941,068,621 - 41,135,261 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021102112   ⟹   XP_020957771
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231182 (Get FASTA)   NCBI Sequence Viewer  
  XP_020957770 (Get FASTA)   NCBI Sequence Viewer  
  XP_020957771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEM97885 (Get FASTA)   NCBI Sequence Viewer  
  AEM97886 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020957771   ⟸   XM_021102112
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020957770   ⟸   XM_021102111
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001231182   ⟸   NM_001244253
- UniProtKB: F1SM69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000053203   ⟸   ENSSSCT00000050179
RefSeq Acc Id: ENSSSCP00000015973   ⟸   ENSSSCT00000016414
RefSeq Acc Id: ENSSSCP00000049999   ⟸   ENSSSCT00000055534
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015048 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070007391 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000015973 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049999 UniProtKB/TrEMBL
  ENSSSCP00000053203 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070011736 UniProtKB/TrEMBL
  ENSSSCP00070011738 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016414 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000050179 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000055534 UniProtKB/TrEMBL
  ENSSSCT00070014221 UniProtKB/TrEMBL
  ENSSSCT00070014224 UniProtKB/TrEMBL
InterPro Dopamine_D2_rcpt UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:100624857 UniProtKB/TrEMBL
NCBI Gene DRD2 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS DOPAMINED2R UniProtKB/TrEMBL
  DOPAMINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniGene Ssc.5297 ENTREZGENE
UniProt A0A287B0Q7_PIG UniProtKB/TrEMBL
  A0A4X1T900_PIG UniProtKB/TrEMBL
  F1SM69 ENTREZGENE, UniProtKB/TrEMBL
  G3ETR1_PIG UniProtKB/TrEMBL
UniProt Secondary G3ETR0 UniProtKB/TrEMBL
VGNC ID VGNC:87444 ENTREZGENE