RGD Reference Report - Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum. - Rat Genome Database

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Stress-induced depressive behaviors are correlated with Par-4 and DRD2 expression in rat striatum.

Authors: Zhu, X  Peng, S  Zhang, S  Zhang, X 
Citation: Zhu X, etal., Behav Brain Res. 2011 Oct 1;223(2):329-35. Epub 2011 May 8.
RGD ID: 6907449
Pubmed: PMID:21596067   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbr.2011.04.052   (Journal Full-text)

Depression is a common mental disorder; however, its molecular mechanism has not been fully elucidated. In this study, we investigated the role of maternal deprivation (MD) and chronic mild stress (CMS) in the pathogenesis of depression in rat models. The mRNA levels of prostate apoptosis response-4 (Par-4) and dopamine receptor D2 (DRD2) genes in the striatum were measured by real-time PCR. Methylation level in the promoter of Par-4 gene was detected by bisulfite sequencing. Correlation between gene expression and depression-like behaviors were analyzed. Our results demonstrated that MD and CMS alone or their combination (dual stresses: DS) caused depression-like behaviors in rats. The mRNA levels of Par-4 and DRD2 genes in the striatum were significantly lower in MD-, CMS-, and DS-treated rats than in control rats. Importantly, Par-4 and DRD2 mRNA levels significantly correlated with depression-like behaviors. However, no significant differences in total methylation levels in the promoter of Par-4 gene were found between four groups. Our study suggested that either maternal deprivation or chronic mild stress plays a crucial role in the development of depression-like behaviors in rats. This process is associated with down-regulated Par-4 and DRD2 gene expression in the striatum through a non-methylation mechanism.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
depressive disorder  ISODrd2 (Rattus norvegicus)6907449; 6907449mRNA:decreased expression:striatumRGD 
depressive disorder  IEP 6907449; 6907449mRNA:decreased expression:striatumRGD 
depressive disorder  ISOPawr (Rattus norvegicus)6907449; 6907449mRNA:decreased expression:striatumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)
Pawr  (pro-apoptotic WT1 regulator)

Genes (Mus musculus)
Drd2  (dopamine receptor D2)
Pawr  (PRKC, apoptosis, WT1, regulator)

Genes (Homo sapiens)
DRD2  (dopamine receptor D2)
PAWR  (pro-apoptotic WT1 regulator)


Additional Information