RGD Reference Report - mRNA D(2) dopaminergic receptor expression after hypoxia-ischemia in rat immature brain. - Rat Genome Database

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mRNA D(2) dopaminergic receptor expression after hypoxia-ischemia in rat immature brain.

Authors: Cantagrel, S  Gressens, P  Bodard, S  Suc, AL  Laugier, J  Guilloteau, D  Chalon, S 
Citation: Cantagrel S, etal., Biol Neonate. 2001 Jul;80(1):68-73.
RGD ID: 1580883
Pubmed: PMID:11474153   (View Abstract at PubMed)
DOI: DOI:47123   (Journal Full-text)

Previous studies have shown a reduction of dopaminergic D(2) receptors (D(2)R) in the striatum after hypoxia-ischemia in newborn rats. We show here an early and transient reduction of mRNA D(2)R in nonatrophic brains following hypoxia-ischemia. The left carotid artery of P7 rats was ligated followed by hypoxia for 2 h. The rats were sacrificed after 24 h, 48 h and 14 days. D(2)R mRNA was studied by in situ hybridization, the cell number by conventional histology, and neuronal and astrocyte differentiation by immunohistochemistry. A 20% reduction of striatal mRNA D(2)R occurred 24 h after hypoxia-ischemia, whereas no reduction was observed after 48 h and 14 days. There were no differences in total cell number and in the expression of neuronal (MAP-1, MAP-2) and astrocyte (GFAP) markers between both brain hemispheres nor between control and hypoxia-ischemia animals. The early decrease in mRNA D(2)R could explain the delayed reduced D(2)R after neonatal hypoxia-ischemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain ischemia  ISODrd2 (Rattus norvegicus)1580883; 1580883 RGD 
brain ischemia  IEP 1580883 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)

Genes (Mus musculus)
Drd2  (dopamine receptor D2)

Genes (Homo sapiens)
DRD2  (dopamine receptor D2)


Additional Information