Arr3 (arrestin 3) - Rat Genome Database

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Gene: Arr3 (arrestin 3) Rattus norvegicus
Analyze
Symbol: Arr3
Name: arrestin 3
RGD ID: 621385
Description: Enables protein domain specific binding activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within endocytosis and regulation of protein phosphorylation. Predicted to be located in photoreceptor inner segment; photoreceptor outer segment; and synapse. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ARR3 (arrestin 3); PARTICIPATES IN eicosanoid signaling pathway; visual phototransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arrestin 3, retinal; arrestin 3, retinal (X-arrestin); arrestin-C; cArr; cone arrestin; retinal cone arrestin-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,739,959 - 69,752,300 (+)NCBIGRCr8
mRatBN7.2X65,699,881 - 65,712,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,698,699 - 65,712,153 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,183,297 - 67,195,639 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,683,687 - 70,696,028 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,244,588 - 68,256,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,438,590 - 70,452,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,438,617 - 70,452,067 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,310,209 - 71,323,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,602,380 - 88,614,721 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,684,283 - 88,688,153 (+)NCBI
CeleraX66,058,741 - 66,071,082 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
2. Identification of quantitative trait Loci for anxiety and locomotion phenotypes in rat recombinant inbred strains. Conti LH, etal., Behav Genet 2004 Jan;34(1):93-103.
3. Cone arrestin identified by targeting expression of a functional family. Craft CM, etal., J Biol Chem 1994 Feb 11;269(6):4613-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The functional cycle of visual arrestins in photoreceptor cells. Gurevich VV, etal., Prog Retin Eye Res. 2011 Nov;30(6):405-30. Epub 2011 Jul 29.
7. Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion. Kishi H, etal., J Biol Chem 2002 Jun 14;277(24):21939-46.
8. Loss of intracellular dystrophin: a potential mechanism for myocardial reperfusion injury. Kyoi S, etal., Circ J. 2003 Aug;67(8):725-7.
9. Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons. Macey TA, etal., Mol Pharmacol. 2004 Dec;66(6):1635-42. Epub 2004 Sep 10.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10725384   PMID:12486395   PMID:15218143   PMID:22159081   PMID:23139825   PMID:23704327   PMID:25972452   PMID:31080119  


Genomics

Comparative Map Data
Arr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,739,959 - 69,752,300 (+)NCBIGRCr8
mRatBN7.2X65,699,881 - 65,712,224 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,698,699 - 65,712,153 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,183,297 - 67,195,639 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,683,687 - 70,696,028 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,244,588 - 68,256,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,438,590 - 70,452,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,438,617 - 70,452,067 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,310,209 - 71,323,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,602,380 - 88,614,721 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,684,283 - 88,688,153 (+)NCBI
CeleraX66,058,741 - 66,071,082 (+)NCBICelera
Cytogenetic MapXq22NCBI
ARR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,268,334 - 70,281,883 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,268,305 - 70,281,840 (+)EnsemblGRCh38hg38GRCh38
GRCh37X69,488,184 - 69,501,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,404,910 - 69,418,415 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X69,271,222 - 69,284,711NCBI
CeleraX69,841,522 - 69,855,024 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,309,253 - 63,322,604 (+)NCBIHuRef
CHM1_1X69,382,163 - 69,395,648 (+)NCBICHM1_1
T2T-CHM13v2.0X68,701,653 - 68,715,201 (+)NCBIT2T-CHM13v2.0
Arr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,649,086 - 99,662,099 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,649,103 - 99,662,099 (+)EnsemblGRCm39 Ensembl
GRCm38X100,605,480 - 100,618,493 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,605,497 - 100,618,493 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X97,800,836 - 97,813,832 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,808,275 - 96,821,212 (+)NCBIMGSCv36mm8
CeleraX87,531,523 - 87,544,518 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.72NCBI
Arr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,819,792 - 9,835,200 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,819,783 - 9,835,526 (+)NCBIChiLan1.0ChiLan1.0
ARR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X69,945,634 - 69,959,110 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X69,949,236 - 69,962,712 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,536,796 - 59,550,274 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,596,163 - 69,609,624 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,596,163 - 69,609,624 (+)Ensemblpanpan1.1panPan2
ARR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,725,034 - 54,730,920 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX54,718,323 - 54,730,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,544,260 - 45,556,911 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,684,406 - 55,697,072 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX55,684,472 - 55,697,004 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X53,653,383 - 53,666,039 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X54,984,189 - 54,997,103 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,911,364 - 54,924,024 (+)NCBIUU_Cfam_GSD_1.0
Arr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,432,077 - 47,445,740 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367621,194,166 - 1,208,844 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367621,194,251 - 1,207,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,296,596 - 56,310,506 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,295,107 - 56,310,507 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,491,381 - 63,505,290 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,111,875 - 60,127,144 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,114,643 - 60,127,255 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660651,958,268 - 1,971,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624903246,888 - 255,169 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arr3
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000003946
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
AI233013  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X65,704,232 - 65,704,340 (+)MAPPERmRatBN7.2
Rnor_6.0X70,444,149 - 70,444,256NCBIRnor6.0
Rnor_5.0X71,315,767 - 71,315,874UniSTSRnor5.0
RGSC_v3.4X88,606,732 - 88,606,839UniSTSRGSC3.4
CeleraX66,063,093 - 66,063,200UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 33 51 49 48 17 25 17 6 126 81 31 11 22 31

Sequence


Ensembl Acc Id: ENSRNOT00000003946   ⟹   ENSRNOP00000003946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,699,881 - 65,712,124 (+)Ensembl
Rnor_6.0 EnsemblX70,440,059 - 70,452,038 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX70,445,516 - 70,446,687 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076671   ⟹   ENSRNOP00000068038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,698,699 - 65,712,153 (+)Ensembl
Rnor_6.0 EnsemblX70,438,617 - 70,452,067 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114787   ⟹   ENSRNOP00000087483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,700,140 - 65,712,124 (+)Ensembl
RefSeq Acc Id: NM_001190993   ⟹   NP_001177922
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,739,959 - 69,752,300 (+)NCBI
mRatBN7.2X65,699,881 - 65,712,224 (+)NCBI
Rnor_6.0X70,439,797 - 70,452,138 (+)NCBI
Rnor_5.0X71,310,209 - 71,323,756 (+)NCBI
CeleraX66,058,741 - 66,071,082 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099437   ⟹   XP_038955365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,741,956 - 69,752,300 (+)NCBI
mRatBN7.2X65,701,878 - 65,712,224 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001177922 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955365 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA17552 (Get FASTA)   NCBI Sequence Viewer  
  EDL95933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003946.4
  ENSRNOP00000068038.2
  ENSRNOP00000087483.1
GenBank Protein P36576 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001177922   ⟸   NM_001190993
- UniProtKB: F1LMR6 (UniProtKB/TrEMBL),   A6IQ79 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003946   ⟸   ENSRNOT00000003946
Ensembl Acc Id: ENSRNOP00000068038   ⟸   ENSRNOT00000076671
RefSeq Acc Id: XP_038955365   ⟸   XM_039099437
- Peptide Label: isoform X1
- UniProtKB: A6IQ79 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087483   ⟸   ENSRNOT00000114787
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36576-F1-model_v2 AlphaFold P36576 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621385 AgrOrtholog
BioCyc Gene G2FUF-2129 BioCyc
Ensembl Genes ENSRNOG00000002904 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003946.5 UniProtKB/TrEMBL
  ENSRNOT00000076671.3 UniProtKB/TrEMBL
  ENSRNOT00000114787.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.840 UniProtKB/TrEMBL
InterPro Arrestin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin-like_C UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/TrEMBL
  Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_CS UniProtKB/TrEMBL
  Arrestin_N UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171107 UniProtKB/TrEMBL
NCBI Gene 171107 ENTREZGENE
PANTHER PTHR11792 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11792:SF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/TrEMBL
  Arrestin_N UniProtKB/TrEMBL
PhenoGen Arr3 PhenoGen
PRINTS ARRESTIN UniProtKB/TrEMBL
PROSITE ARRESTINS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002904 RatGTEx
SMART Arrestin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJ89_RAT UniProtKB/TrEMBL
  A0A8I6A8Q4_RAT UniProtKB/TrEMBL
  A6IQ79 ENTREZGENE, UniProtKB/TrEMBL
  ARRC_RAT UniProtKB/Swiss-Prot
  F1LMR6 ENTREZGENE, UniProtKB/TrEMBL
  P36576 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Arr3  arrestin 3  Arr3  arrestin 3, retinal (X-arrestin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Arr3  arrestin 3, retinal (X-arrestin)  Arr3  arrestin 3, retinal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Arr3  arrestin 3, retinal    arrestin 3, retinal (X-arrestin)  Name updated 1299863 APPROVED
2002-08-07 Arr3  arrestin 3, retinal (X-arrestin)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog located at X chromosome, may be candidate for several inherited X-linked retinopathies 727257
gene_expression present in the retina with cone photoreceptors and in the pineal to a subpopulation of pinealocytes 727257
gene_function binds to cone-related G-protein-coupled receptors 727257