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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lysergic acid diethylamide
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Accession:CHEBI:6605 term browser browse the term
Definition:An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.
Synonyms:exact_synonym: (8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide
 related_synonym: D-lysergic acid diethylamide;   Formula=C20H25N3O;   InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1;   InChIKey=VAYOSLLFUXYJDT-RDTXWAMCSA-N;   LSD;   LSD 25;   Lysergide;   Lysergsaeurediaethylamid;   Lysergsaeurediethylamid;   N,N-diethyl-(+)-lysergamide;   N,N-diethyl-D-lysergamide;   N,N-diethyllysergamide;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N(CC)CC)c34
 xref: Beilstein:94179;   CAS:50-37-3;   Drug_Central:1621;   KEGG:C07542
 xref_mesh: MESH:D008238
 xref: MetaCyc:CPD-14458;   PMID:11723224;   PMID:13952224;   PMID:16005500;   PMID:17077317;   PMID:22898355;   PMID:23222128;   PMID:23423312;   PMID:24594678;   PMID:24785760;   PMID:24830180;   PMID:25036425;   PMID:8428600;   PMID:9698051;   Patent:US2736728;   Patent:US2774763;   Patent:US3141887;   Reaxys:94179;   Wikipedia:Lysergic_acid_diethylamide

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lysergic acid diethylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects binding EXP LSD binds to Drd2 protein RGD PMID:15852061 RGD:1581406 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Lysergic Acid Diethylamide results in increased expression of FOS mRNA CTD PMID:10521585 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions
affects binding
ISO 2-aminoindan analog inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]; Lysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein] CTD PMID:14659797 PMID:29458138 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B multiple interactions EXP lysergic acid diethylamide binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b] RGD PMID:8224165 RGD:2303647 NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 affects binding ISO Lysergic Acid Diethylamide binds to HTR6 protein CTD PMID:21866910 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        pharmacological role 19087
          neurotransmitter agent 16522
            serotonergic drug 4254
              serotonergic agonist 981
                lysergic acid diethylamide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                monocarboxylic acid amide 15515
                                                  lysergic acid diethylamide 5
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