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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lysergic acid diethylamide
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Accession:CHEBI:6605 term browser browse the term
Definition:An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.
Synonyms:exact_synonym: (8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide
 related_synonym: D-lysergic acid diethylamide;   Formula=C20H25N3O;   InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1;   InChIKey=VAYOSLLFUXYJDT-RDTXWAMCSA-N;   LSD;   LSD 25;   Lysergide;   Lysergsaeurediaethylamid;   Lysergsaeurediethylamid;   N,N-diethyl-(+)-lysergamide;   N,N-diethyl-D-lysergamide;   N,N-diethyllysergamide;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N(CC)CC)c34
 xref: Beilstein:94179;   CAS:50-37-3;   Drug_Central:1621;   KEGG:C07542
 xref_mesh: MESH:D008238
 xref: MetaCyc:CPD-14458;   PMID:11723224;   PMID:13952224;   PMID:16005500;   PMID:17077317;   PMID:22898355;   PMID:23222128;   PMID:23423312;   PMID:24594678;   PMID:24785760;   PMID:24830180;   PMID:25036425;   PMID:8428600;   PMID:9698051;   Patent:US2736728;   Patent:US2774763;   Patent:US3141887;   Reaxys:94179;   Wikipedia:Lysergic_acid_diethylamide

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lysergic acid diethylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Lysergic Acid Diethylamide results in increased expression of FOS mRNA CTD PMID:10521585 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions
affects binding
ISO 2-aminoindan analog inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]; Lysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein] CTD PMID:14659797, PMID:29458138 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 affects binding ISO Lysergic Acid Diethylamide binds to HTR6 protein CTD PMID:21866910 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        pharmacological role 18793
          neurotransmitter agent 16423
            serotonergic drug 3956
              serotonergic agonist 978
                lysergic acid diethylamide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  lysergic acid diethylamide 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.