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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lysergic acid diethylamide
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Accession:CHEBI:6605 term browser browse the term
Definition:An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.
Synonyms:exact_synonym: (8R)-9,10-didehydro-N,N-diethyl-6-methylergoline-8-carboxamide
 related_synonym: D-lysergic acid diethylamide;   Formula=C20H25N3O;   InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1;   InChIKey=VAYOSLLFUXYJDT-RDTXWAMCSA-N;   LSD;   LSD 25;   Lysergide;   Lysergsaeurediaethylamid;   Lysergsaeurediethylamid;   N,N-diethyl-(+)-lysergamide;   N,N-diethyl-D-lysergamide;   N,N-diethyllysergamide;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N(CC)CC)c34
 xref: Beilstein:94179;   CAS:50-37-3;   Drug_Central:1621;   KEGG:C07542
 xref_mesh: MESH:D008238
 xref: MetaCyc:CPD-14458;   PMID:11723224;   PMID:13952224;   PMID:16005500;   PMID:17077317;   PMID:22898355;   PMID:23222128;   PMID:23423312;   PMID:24594678;   PMID:24785760;   PMID:24830180;   PMID:25036425;   PMID:8428600;   PMID:9698051;   Patent:US2736728;   Patent:US2774763;   Patent:US3141887;   Reaxys:94179;   Wikipedia:Lysergic_acid_diethylamide

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lysergic acid diethylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects binding EXP LSD binds to Drd2 protein RGD PMID:15852061 RGD:1581406 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Lysergic Acid Diethylamide results in increased expression of FOS mRNA CTD PMID:10521585 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions
affects binding
ISO 2-aminoindan analog inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]; Lysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein] CTD PMID:14659797 PMID:29458138 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr5b 5-hydroxytryptamine (serotonin) receptor 5B multiple interactions EXP lysergic acid diethylamide binds to protein 5-Htr5b; inhibits the reaction[5-carboxamidotryptamine binds to 5-Htr5b] RGD PMID:8224165 RGD:2303647 NCBI chr13:32,686,911...32,699,835
Ensembl chr13:32,687,042...32,699,835
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 affects binding ISO Lysergic Acid Diethylamide binds to HTR6 protein CTD PMID:21866910 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19812
    role 19761
      biological role 19761
        pharmacological role 18842
          neurotransmitter agent 16452
            serotonergic drug 3980
              serotonergic agonist 984
                lysergic acid diethylamide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  lysergic acid diethylamide 5
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