DRD2 (dopamine receptor D2) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: DRD2 (dopamine receptor D2) Canis lupus familiaris
Analyze
Symbol: DRD2
Name: dopamine receptor D2
RGD ID: 12312848
Description: ENCODES a protein that exhibits ionotropic glutamate receptor binding (ortholog); protein-containing complex binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN acid secretion (ortholog); activation of protein kinase activity (ortholog); adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; ASSOCIATED WITH Alcoholic Intoxication (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN acrosomal vesicle (ortholog); axon terminus (ortholog); cilium (ortholog); INTERACTS WITH pyridines; risperidone
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D(2) dopamine receptor; dopamine D2 receptor short isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1519,732,842 - 19,795,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
pyridines  (EXP)
risperidone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acid secretion  (ISO)
activation of protein kinase activity  (ISO)
adenohypophysis development  (IEA)
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (IBA,IEA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
adult behavior  (ISO)
adult walking behavior  (IEA)
arachidonic acid secretion  (IEA)
associative learning  (ISO)
auditory behavior  (ISO)
autophagy  (ISO)
axonogenesis  (IEA)
behavioral response to cocaine  (IEA)
behavioral response to ethanol  (IEA)
branching morphogenesis of a nerve  (IEA)
cerebral cortex GABAergic interneuron migration  (IEA)
circadian regulation of gene expression  (IEA)
dopamine metabolic process  (IEA)
dopamine receptor signaling pathway  (ISO)
drinking behavior  (ISO)
feeding behavior  (IEA)
forebrain development  (ISO)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
grooming behavior  (IEA)
hyaloid vascular plexus regression  (IEA,ISS)
intracellular signal transduction  (ISO)
locomotory behavior  (ISO)
long-term memory  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of adenylate cyclase activity  (IBA)
negative regulation of blood pressure  (IEA)
negative regulation of cell death  (ISO)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of cytosolic calcium ion concentration  (IBA)
negative regulation of dopamine receptor signaling pathway  (IEA)
negative regulation of dopamine secretion  (ISO)
negative regulation of innate immune response  (IEA)
negative regulation of insulin secretion  (ISO)
negative regulation of protein kinase B signaling  (IEA)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein secretion  (IEA)
negative regulation of synaptic transmission  (ISO)
negative regulation of synaptic transmission, glutamatergic  (IBA)
negative regulation of voltage-gated calcium channel activity  (IBA)
nervous system process involved in regulation of systemic arterial blood pressure  (IEA)
neuron-neuron synaptic transmission  (IEA)
orbitofrontal cortex development  (ISO)
peristalsis  (IEA)
phospholipase C-activating dopamine receptor signaling pathway  (IBA)
pigmentation  (IEA)
positive regulation of cytokinesis  (IEA)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA)
positive regulation of dopamine uptake involved in synaptic transmission  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of glial cell-derived neurotrophic factor production  (IEA)
positive regulation of growth hormone secretion  (IEA)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of multicellular organism growth  (IEA)
positive regulation of neuroblast proliferation  (IEA)
positive regulation of neurogenesis  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of renal sodium excretion  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urine volume  (IEA)
postsynaptic modulation of chemical synaptic transmission  (ISO)
prepulse inhibition  (IEA,ISO)
protein localization  (IEA)
regulation of dopamine secretion  (IBA)
regulation of dopamine uptake involved in synaptic transmission  (ISO)
regulation of heart rate  (IEA)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of long-term neuronal synaptic plasticity  (IEA)
regulation of MAPK cascade  (ISO)
regulation of neurotransmitter uptake  (ISO)
regulation of phosphoprotein phosphatase activity  (ISO)
regulation of potassium ion transport  (IBA)
regulation of sodium ion transport  (IEA)
regulation of synapse structural plasticity  (ISO)
regulation of synaptic transmission, GABAergic  (IEA)
regulation of synaptic vesicle exocytosis  (IEA)
release of sequestered calcium ion into cytosol  (ISO)
response to amphetamine  (IEA)
response to axon injury  (ISO)
response to cocaine  (ISO)
response to drug  (IEA)
response to ethanol  (ISO)
response to histamine  (IEA)
response to hypoxia  (ISO)
response to inactivity  (ISO)
response to iron ion  (ISO)
response to light stimulus  (ISO)
response to morphine  (IEA)
response to nicotine  (ISO)
response to toxic substance  (ISO)
sensory perception of smell  (IEA)
startle response  (ISO)
striatum development  (ISO)
synapse assembly  (ISO)
synaptic transmission, dopaminergic  (IEA)
temperature homeostasis  (IEA)
visual learning  (IEA)
Wnt signaling pathway  (ISO)

References
Additional References at PubMed
PMID:11054572   PMID:18483151   PMID:18773888  


Genomics

Comparative Map Data
DRD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1519,732,842 - 19,795,241 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
DRD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11113,409,605 - 113,475,691 (-)EnsemblGRCh38hg38GRCh38
GRCh3811113,409,605 - 113,475,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711113,280,317 - 113,346,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,785,527 - 112,851,091 (-)NCBINCBI36hg18NCBI36
Build 3411112,785,527 - 112,851,103NCBI
Celera11110,433,249 - 110,498,937 (-)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11109,208,766 - 109,274,420 (-)NCBIHuRef
CHM1_111113,163,302 - 113,228,980 (-)NCBICHM1_1
Drd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,251,633 - 49,319,477 (+)NCBIGRCm39mm39
GRCm38949,340,360 - 49,408,177 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,340,627 - 49,408,177 (+)EnsemblGRCm38mm10GRCm38
MGSCv37949,148,767 - 49,215,319 (+)NCBIGRCm37mm9NCBIm37
MGSCv36949,092,857 - 49,160,407 (+)NCBImm8
Celera946,638,220 - 46,705,025 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.72NCBI
Drd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0853,678,777 - 53,743,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,678,777 - 53,743,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,298,097 - 52,363,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,641,160 - 52,707,749 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,660,213 - 52,726,803 (+)NCBI
Celera849,262,252 - 49,324,732 (+)NCBICelera
Cytogenetic Map8q23NCBI
Drd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,054,038 - 15,114,573 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,054,255 - 15,114,558 (-)NCBIChiLan1.0ChiLan1.0
DRD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111112,132,703 - 112,168,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,132,703 - 112,198,935 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011108,289,838 - 108,357,174 (-)NCBIMhudiblu_PPA_v0panPan3
Drd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366121,094,686 - 1,154,149 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,068,779 - 41,133,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,068,618 - 41,135,262 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2945,883,054 - 45,897,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DRD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,774,632 - 104,843,417 (-)NCBI
ChlSab1.1 Ensembl1104,774,180 - 104,842,736 (-)Ensembl
Drd2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247848,828,589 - 8,906,617 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system
High
Medium 6 6
Low 1 5
Below cutoff 5 1 8 1 5 1 2 1 1 7 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000022040   ⟹   ENSCAFP00000020466
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000022043   ⟹   ENSCAFP00000020469
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl519,732,836 - 19,795,241 (+)Ensembl
RefSeq Acc Id: NM_001003110   ⟹   NP_001003110
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1519,782,598 - 19,794,135 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005619479   ⟹   XP_005619536
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1519,732,842 - 19,795,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_014113171   ⟹   XP_013968646
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1519,733,361 - 19,795,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022418007   ⟹   XP_022273715
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1519,732,842 - 19,795,241 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005619536   ⟸   XM_005619479
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013968646   ⟸   XM_014113171
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001003110   ⟸   NM_001003110
- UniProtKB: Q9GJU1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_022273715   ⟸   XM_022418007
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000020469   ⟸   ENSCAFT00000022043
RefSeq Acc Id: ENSCAFP00000020466   ⟸   ENSCAFT00000022040
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:13683155
Promoter ID:EPDNEW_C1223
Type:single initiation site
Name:DRD2_1
Description:dopamine receptor D2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1519,732,892 - 19,732,952EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000020466 UniProtKB/TrEMBL
  ENSCAFP00000020469 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022040 UniProtKB/TrEMBL
  ENSCAFT00000022043 UniProtKB/TrEMBL
InterPro Dopamine_D2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dopamine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403701 UniProtKB/Swiss-Prot
NCBI Gene DRD2 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DOPAMINED2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DOPAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DRD2_CANLF UniProtKB/Swiss-Prot
  F1PMQ9_CANLF UniProtKB/TrEMBL
  Q9GJU1 ENTREZGENE
  Q9GK99_CANLF UniProtKB/TrEMBL
  Q9GKA0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40094 ENTREZGENE