RGD Reference Report - Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction. - Rat Genome Database

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Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction.

Authors: Grzywacz, Anna  Jasiewicz, Andrzej  Małecka, Iwona  Suchanecka, Aleksandra  Grochans, Elżbieta  Karakiewicz, Beata  Samochowiec, Agnieszka  Bieńkowski, Przemysław  Samochowiec, Jerzy 
Citation: Grzywacz A, etal., Pharmacol Rep. 2012;64(5):1126-34. doi: 10.1016/s1734-1140(12)70909-x.
RGD ID: 401959213
Pubmed: PMID:23238469   (View Abstract at PubMed)
DOI: DOI:10.1016/s1734-1140(12)70909-x   (Journal Full-text)


BACKGROUND: We investigated the relationship between withdrawal syndrome symptoms and dopamine receptor 2 DRD2 gene polymorphisms-141 C I/D (rs1799732) exon 8 G/A (rs6276) and ANKK1 (Ankyrin Repeat and Kinase Domain Containing 1) gene polymorphism Taq1A (rs1800497).
MATERIAL: A total number of 213 patients who met the ICD 10 criteria for given phenotypes were enrolled in the study. Those phenotypes included: dissocial personality disorder, early onset, alcohol withdrawal syndrome with seizures, alcohol withdrawal syndrome with delirium tremens, and alcohol withdrawal syndrome with seizures and delirium tremens.
RESULTS: Our results show statistically significant associations between SNP in exon 8 A/G in the DRD2 gene and alcohol withdrawal syndrome with seizures, and between SNP in promoter -141 C I/D in the DRD2 gene and early onset of alcohol dependence (AD). The A/A genotype in exon 8 A/G polymorphism seems to be a positive predictive factor for the presence or the lack of seizures in alcohol withdrawal syndrome. The A/G genotype is possibly a protective factor for this AD phenotype.
CONCLUSIONS: These results suggest that both investigated DRD2 polymorphisms have an impact on the AD phenotype. The findings of the presented study reconfirm that dopamine receptor 2 gene polymorphisms are associated with alcohol addiction and alcohol withdrawal syndrome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DRD2Humanalcohol dependence onsetIAGP DNA:insertion and deletion:promoter:RGD 
Drd2Ratalcohol dependence onsetISODRD2 (Homo sapiens)DNA:insertion and deletion:promoter:RGD 
Drd2Mousealcohol dependence onsetISODRD2 (Homo sapiens)DNA:insertion and deletion:promoter:RGD 
DRD2HumanAlcohol Withdrawal Seizures susceptibilityIAGP DNA:SNP:exon:A>G(human)RGD 
Drd2RatAlcohol Withdrawal Seizures susceptibilityISODRD2 (Homo sapiens)DNA:SNP:exon:A>G(human)RGD 
Drd2MouseAlcohol Withdrawal Seizures susceptibilityISODRD2 (Homo sapiens)DNA:SNP:exon:A>G(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)

Genes (Mus musculus)
Drd2  (dopamine receptor D2)

Genes (Homo sapiens)
DRD2  (dopamine receptor D2)


Additional Information