RGD Reference Report - Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. - Rat Genome Database

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Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade.

Authors: Du Bois, TM  Hsu, CW  Li, Y  Tan, YY  Deng, C  Huang, XF 
Citation: du Bois TM, etal., Neurochem Res. 2008 Jul;33(7):1224-31. Epub 2008 Feb 8.
RGD ID: 2311568
Pubmed: PMID:18256931   (View Abstract at PubMed)
DOI: DOI:10.1007/s11064-007-9571-y   (Journal Full-text)

This study examined how perinatal phencyclidine (PCP) treatment would affect dopamine D2 receptor and dopamine transporter (DAT) binding at different stages after treatment cessation. Female rat pups received injections of PCP (10 mg/kg, s.c.) or saline on postnatal day (PN)7, 9 and 11. D2 receptor and transporter binding was examined at four time-points (PN12, 18, 32 and 96) following injections. PCP treatment altered D2 receptor binding throughout development, with a final end-point of 22-33% decreased binding at adulthood in the nucleus accumbens and caudate putamen (P < 0.01), accompanied by a small but significant increase in DAT binding in the caudate putamen. Tyrosine hydroxylase mRNA expression was also significantly increased by 25% (P < 0.05) in the ventral tegmental area of adult rats, suggesting that this model may produce a long-term increase in dopamine output. This study demonstrates that early insult to the brain from NMDA receptor hypofunction alters the dopaminergic system at different stages of development.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPISlc6a3 (Rattus norvegicus)2311568 RGD 
signaling receptor binding  IPIDrd2 (Rattus norvegicus)2311568 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd2  (dopamine receptor D2)
Slc6a3  (solute carrier family 6 member 3)


Additional Information