ONTOLOGY REPORT - ANNOTATIONS
Term: site of double-strand break
Accession: GO:0035861
browse the term
Definition: A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
Synonyms: exact_synonym: site of DSB
related_synonym: DNA damage foci; DNA damage focus; IRIF; ionizing radiation-induced foci
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Actr2
actin related protein 2
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr11:20,012,304...20,062,951
Ensembl chr11:20,012,304...20,062,913
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Aim2
absent in melanoma 2
is_active_in
IDA
(PMID:27846608)
UniProt
PMID:27846608
NCBI chr 1:173,177,105...173,293,606
Ensembl chr 1:173,178,445...173,293,606
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Aplf
aprataxin and PNKP like factor
is_active_in located_in
IBA ISO
GO_Central MGI
GO_REF:0000008 GO_REF:0000033
NCBI chr 6:87,605,407...87,649,244
Ensembl chr 6:87,605,406...87,649,175
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Asf1a
anti-silencing function 1A histone chaperone
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr10:53,473,057...53,485,321
Ensembl chr10:53,472,853...53,485,321
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Atf2
activating transcription factor 2
located_in
IMP ISO
(MGI:5882896|PMID:15916964)
CAFA MGI
PMID:15916964
GO_REF:0000119 MGI:4834177 MGI:5882896
NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
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Atm
ataxia telangiectasia mutated
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
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Brme1
break repair meiotic recombinase recruitment factor 1
is_active_in
IDA
(PMID:32463460)
UniProt
PMID:32463460
NCBI chr 8:84,874,637...84,899,220
Ensembl chr 8:84,874,654...84,899,219
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Cgas
cyclic GMP-AMP synthase
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr 9:78,337,800...78,350,519
Ensembl chr 9:78,337,808...78,350,519
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Chd1l
chromodomain helicase DNA binding protein 1-like
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 3:97,468,056...97,517,538
Ensembl chr 3:97,468,058...97,517,519
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Cntd1
cyclin N-terminal domain containing 1
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr11:101,170,029...101,179,527
Ensembl chr11:101,169,838...101,187,143
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Cyren
cell cycle regulator of NHEJ
is_active_in
IDA
(MGI:6202149|PMID:30017584)
UniProt
PMID:30017584
MGI:6202149
NCBI chr 6:34,848,706...34,855,024
Ensembl chr 6:34,848,706...34,854,995
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Ddb1
damage specific DNA binding protein 1
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr19:10,582,961...10,607,186
Ensembl chr19:10,582,691...10,607,183
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Dmc1
DNA meiotic recombinase 1
is_active_in
IDA
(PMID:30760716), (PMID:32463460)
UniProt
PMID:30760716 PMID:32463460
NCBI chr15:79,445,698...79,489,362
Ensembl chr15:79,445,698...79,489,310
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Dynll1
dynein light chain LC8-type 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 5:115,435,129...115,438,995
Ensembl chr 5:115,435,169...115,439,058
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Epc1
enhancer of polycomb homolog 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr18:6,435,951...6,516,108
Ensembl chr18:6,435,951...6,516,108
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Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
located_in
IDA
(PMID:22614755), (PMID:22699483)
MGI
PMID:22614755 PMID:22699483
NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443
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Fh1
fumarate hydratase 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201
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H2ax
H2A.X variant histone
located_in is_active_in
ISO IDA
(PMID:22699483), (PMID:23133398) (PMID:12419185)
MGI UniProt
PMID:12419185 PMID:22699483 PMID:23133398
GO_REF:0000008
NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
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Helb
helicase (DNA) B
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr10:119,919,513...119,948,917
Ensembl chr10:119,919,513...119,948,892
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Htatsf1
HIV TAT specific factor 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr X:56,098,930...56,112,543
Ensembl chr X:56,098,943...56,112,543
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Hus1
HUS1 checkpoint clamp component
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr11:8,943,137...8,961,240
Ensembl chr11:8,943,137...8,961,191
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Hus1b
HUS1 checkpoint clamp component B
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr13:31,130,559...31,131,744
Ensembl chr13:31,130,556...31,131,742
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Iffo1
intermediate filament family orphan 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 6:125,122,167...125,138,746
Ensembl chr 6:125,122,204...125,138,745
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Inip
INTS3 and NABP interacting protein
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 4:59,769,637...59,783,855
Ensembl chr 4:59,769,637...59,801,589
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Ints3
integrator complex subunit 3
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 3:90,298,691...90,340,800
Ensembl chr 3:90,298,695...90,340,929
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Kat5
K(lysine) acetyltransferase 5
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr19:5,653,042...5,661,584
Ensembl chr19:5,653,042...5,660,265
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Kdm4d
lysine (K)-specific demethylase 4D
located_in
IDA ISO
(PMID:24550317)
MGI
PMID:24550317
NCBI chr 9:14,373,844...14,411,818
Ensembl chr 9:14,373,844...14,411,778
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Lmna
lamin A
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263
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Mad2l2
MAD2 mitotic arrest deficient-like 2
located_in
NAS
(MGI:6156517|PMID:29656893)
ComplexPortal
PMID:29656893
MGI:6156517
NCBI chr 4:148,214,615...148,230,161
Ensembl chr 4:148,214,841...148,230,156
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Mbtd1
mbt domain containing 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr11:93,776,635...93,837,815
Ensembl chr11:93,776,678...93,837,811
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Mdc1
mediator of DNA damage checkpoint 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr17:36,152,390...36,170,562
Ensembl chr17:36,152,407...36,170,562
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Mms22l
MMS22-like, DNA repair protein
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 4:24,496,451...24,602,950
Ensembl chr 4:24,496,451...24,602,950
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Mre11a
MRE11A homolog A, double strand break repair nuclease
is_active_in located_in
ISO IBA
(PMID:15916964), (PMID:30612738)
MGI UniProt GO_Central
PMID:15916964 PMID:30612738
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr 9:14,695,971...14,748,421
Ensembl chr 9:14,695,950...14,748,419
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Nabp1
nucleic acid binding protein 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 1:51,504,127...51,517,634
Ensembl chr 1:51,505,021...51,517,584
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Nabp2
nucleic acid binding protein 2
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr10:128,237,263...128,247,426
Ensembl chr10:128,237,264...128,247,361
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Nbn
nibrin
is_active_in located_in
ISO
(PMID:15916964)
MGI UniProt
PMID:15916964
GO_REF:0000119 MGI:4834177
NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589
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Nhej1
non-homologous end joining factor 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 1:75,006,505...75,101,870
Ensembl chr 1:75,006,298...75,101,844
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Parp1
poly (ADP-ribose) polymerase family, member 1
located_in is_active_in
ISO
(PMID:26344098), (PMID:27568560), (PMID:30356214)
UniProt MGI
PMID:26344098 PMID:27568560 PMID:30356214
GO_REF:0000119 MGI:4834177
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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Parp3
poly (ADP-ribose) polymerase family, member 3
is_active_in located_in
IBA ISO IDA
(PMID:21270334)
GO_Central MGI
PMID:21270334
GO_REF:0000008 GO_REF:0000033
NCBI chr 9:106,347,521...106,354,148
Ensembl chr 9:106,347,521...106,354,148
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Paxx
non-homologous end joining factor
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr 2:25,345,132...25,352,666
Ensembl chr 2:25,345,153...25,351,106
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Peli1
pellino 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323
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Phf1
PHD finger protein 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr17:27,152,101...27,156,882
Ensembl chr17:27,152,026...27,156,882
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Pnkp
polynucleotide kinase 3'- phosphatase
is_active_in
IDA ISO
(MGI:5780352|PMID:26774286)
UniProt MGI
PMID:26774286
GO_REF:0000119 MGI:4834177 MGI:5780352
NCBI chr 7:44,505,903...44,514,761
Ensembl chr 7:44,506,563...44,512,416
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Polh
polymerase (DNA directed), eta (RAD 30 related)
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr17:46,482,281...46,513,567
Ensembl chr17:46,482,281...46,513,571
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Poll
polymerase (DNA directed), lambda
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr19:45,540,714...45,549,025
Ensembl chr19:45,540,714...45,548,970
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Polq
polymerase (DNA directed), theta
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr16:36,832,104...36,922,321
Ensembl chr16:36,832,148...36,915,779
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Prpf19
pre-mRNA processing factor 19
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr19:10,872,595...10,886,923
Ensembl chr19:10,872,595...10,886,923
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Rad17
RAD17 checkpoint clamp loader component
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr13:100,753,672...100,787,569
Ensembl chr13:100,753,672...100,787,559
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Rad18
RAD18 E3 ubiquitin protein ligase
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 6:112,596,812...112,673,650
Ensembl chr 6:112,596,811...112,673,647
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Rad50
RAD50 double strand break repair protein
is_active_in located_in
ISO
(PMID:15916964)
MGI UniProt
PMID:15916964
GO_REF:0000119 MGI:4834177
NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146
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Rad51
RAD51 recombinase
is_active_in located_in
ISO IDA
(PMID:24550317) (PMID:30760716), (PMID:32463460)
MGI UniProt
PMID:24550317 PMID:30760716 PMID:32463460
GO_REF:0000119 MGI:4834177
NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926
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Rbbp8
retinoblastoma binding protein 8, endonuclease
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr18:11,766,333...11,876,264
Ensembl chr18:11,766,333...11,878,278
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Rfwd3
ring finger and WD repeat domain 3
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 8:111,997,576...112,026,854
Ensembl chr 8:111,997,576...112,026,854
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Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 6:128,333,962...128,339,876
Ensembl chr 6:128,333,963...128,339,874
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Rif1
replication timing regulatory factor 1
located_in
IDA IMP ISO
(MGI:5468036|PMID:23306439), (MGI:5468037|PMID:23306437) (MGI:5476381|PMID:23333305)
UniProt MGI
PMID:23306437 PMID:23306439 PMID:23333305
GO_REF:0000119 MGI:4834177 MGI:5468036 MGI:5468037 MGI:5476381
NCBI chr 2:51,962,725...52,016,781
Ensembl chr 2:51,962,844...52,012,395
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Rnf138
ring finger protein 138
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr18:21,134,202...21,161,281
Ensembl chr18:21,134,398...21,161,281
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Rnf138rt1
ring finger protein 138, retrogene 1
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr X:162,543,135...162,544,328
Ensembl chr X:162,543,135...162,544,325
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Rnf168
ring finger protein 168
located_in is_active_in
ISO IBA
(PMID:19500350), (PMID:21041483)
UniProt MGI GO_Central
PMID:19500350 PMID:21041483
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr16:32,096,279...32,120,260
Ensembl chr16:32,096,277...32,120,252
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Rnf169
ring finger protein 169
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr 7:99,569,461...99,630,537
Ensembl chr 7:99,569,461...99,629,655
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Rnf8
ring finger protein 8
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr17:29,833,763...29,860,638
Ensembl chr17:29,833,764...29,863,965
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Rpa1
replication protein A1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr11:75,191,085...75,239,478
Ensembl chr11:75,188,992...75,239,150
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Rpa2
replication protein A2
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr 4:132,495,671...132,506,057
Ensembl chr 4:132,495,643...132,506,063
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Rpa3
replication protein A3
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 6:8,255,936...8,259,141
Ensembl chr 6:8,255,936...8,259,173
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Samhd1
SAM domain and HD domain, 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 2:156,939,454...156,977,016
Ensembl chr 2:156,939,453...156,977,185
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Setmar
SET domain without mariner transposase fusion
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 6:108,042,006...108,054,088
Ensembl chr 6:108,042,006...108,054,083
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Shld1
shieldin complex subunit 1
located_in is_active_in
NAS ISO IBA
(MGI:6156517|PMID:29656893)
ComplexPortal MGI GO_Central
PMID:29656893
GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6156517
NCBI chr 2:132,528,871...132,592,975
Ensembl chr 2:132,528,851...132,592,975
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Shld2
shieldin complex subunit 2
located_in is_active_in
NAS ISO IBA
(MGI:6156517|PMID:29656893)
ComplexPortal MGI GO_Central
PMID:29656893
GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6156517
NCBI chr14:33,958,905...34,032,528
Ensembl chr14:33,958,990...34,032,450
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Shld3
shieldin complex subunit 3
located_in
NAS ISO
(MGI:6156517|PMID:29656893)
ComplexPortal MGI
PMID:29656893
GO_REF:0000119 MGI:4834177 MGI:6156517
NCBI chr13:104,310,228...104,314,967
Ensembl chr13:104,310,230...104,314,947
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Sirt6
sirtuin 6
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631
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Sirt7
sirtuin 7
located_in
IMP ISO
(MGI:5789069|PMID:27225932)
UniProt MGI
PMID:27225932
GO_REF:0000119 MGI:4834177 MGI:5789069
NCBI chr11:120,509,197...120,515,840
Ensembl chr11:120,509,198...120,516,066
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Slf1
SMC5-SMC6 complex localization factor 1
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr13:77,191,207...77,283,632
Ensembl chr13:77,191,207...77,283,592
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Slf2
SMC5-SMC6 complex localization factor 2
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr19:44,906,948...44,972,225
Ensembl chr19:44,919,558...44,972,225
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Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 8:81,426,572...81,466,088
Ensembl chr 8:81,425,136...81,466,126
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Smarcad1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 6:65,019,577...65,093,045
Ensembl chr 6:65,019,567...65,093,045
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Smarcal1
SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 1:72,575,593...72,675,949
Ensembl chr 1:72,622,410...72,672,293
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Smc5
structural maintenance of chromosomes 5
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr19:23,183,817...23,251,286
Ensembl chr19:23,183,815...23,251,261
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Smc6
structural maintenance of chromosomes 6
located_in is_active_in
ISO IBA
MGI GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177
NCBI chr12:11,315,887...11,369,786
Ensembl chr12:11,315,887...11,369,786
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Smchd1
SMC hinge domain containing 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr17:71,651,484...71,782,361
Ensembl chr17:71,651,484...71,782,338
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Stk38
serine/threonine kinase 38
is_active_in
ISO
(PMID:32537488)
UniProt
PMID:32537488
NCBI chr17:29,189,854...29,226,979
Ensembl chr17:29,189,854...29,226,969
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Timeless
timeless circadian clock 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr10:128,067,932...128,088,810
Ensembl chr10:128,067,934...128,088,810
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Tonsl
tonsoku-like, DNA repair protein
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr15:76,510,437...76,524,129
Ensembl chr15:76,510,202...76,524,158
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Topbp1
topoisomerase (DNA) II binding protein 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 9:103,182,351...103,227,627
Ensembl chr 9:103,182,414...103,227,627
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Trp53
transformation related protein 53
located_in
IDA
(PMID:24550317)
MGI
PMID:24550317
NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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Trp53bp1
transformation related protein 53 binding protein 1
located_in is_active_in
IDA ISO
(MGI:5476381|PMID:23333305), (MGI:5887191|PMID:23209566)
UniProt MGI
PMID:23209566 PMID:23333305
GO_REF:0000119 MGI:4834177 MGI:5476381 MGI:5887191
NCBI chr 2:121,025,316...121,126,830
Ensembl chr 2:121,023,762...121,101,888
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Ufl1
UFM1 specific ligase 1
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 4:25,247,149...25,281,821
Ensembl chr 4:25,248,600...25,281,821
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Uimc1
ubiquitin interaction motif containing 1
is_active_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr13:55,175,693...55,248,176
Ensembl chr13:55,175,693...55,248,113
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Vcp
valosin containing protein
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507
G
Was
Wiskott-Aldrich syndrome
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr X:7,947,705...7,956,730
Ensembl chr X:7,947,692...7,956,737
G
Wdr70
WD repeat domain 70
is_active_in
IBA
GO_Central
GO_REF:0000033
NCBI chr15:7,902,536...8,138,787
Ensembl chr15:7,902,536...8,128,693
G
Wrap53
WD repeat containing, antisense to Trp53
located_in
ISO
MGI
GO_REF:0000119 MGI:4834177
NCBI chr11:69,452,580...69,471,076
Ensembl chr11:69,452,584...69,471,081
G
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
located_in is_active_in
ISO
(PMID:31548606)
UniProt MGI
PMID:31548606
GO_REF:0000119 MGI:4834177
NCBI chr13:89,997,033...90,237,727
Ensembl chr13:89,922,146...90,237,727
G
Zbtb7a
zinc finger and BTB domain containing 7a
located_in
IDA
(MGI:5702356|PMID:26446488)
UniProt
PMID:26446488
MGI:5702356
NCBI chr10:80,971,113...80,988,056
Ensembl chr10:80,971,054...80,988,829
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