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Gene: Topbp1 (topoisomerase (DNA) II binding protein 1) Mus musculus
Symbol: Topbp1
Name: topoisomerase (DNA) II binding protein 1
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to DNA damage stimulus (ortholog); reciprocal meiotic recombination (ortholog); response to ionizing radiation (ortholog); ASSOCIATED WITH abnormal cell cycle; abnormal cell physiology; abnormal cerebral cortex morphology; ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); FOUND IN chromosome; condensed nuclear chromosome; male germ cell nucleus; INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 17beta-estradiol
Type: protein-coding
Also known as: 1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; mKIAA0259; topoisomerase (DNA) II beta binding protein
Homo sapiens (human) : TOPBP1 (DNA topoisomerase II binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Topbp1 (DNA topoisomerase II binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Topbp1 (DNA topoisomerase II binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TOPBP1 (DNA topoisomerase II binding protein 1)
Canis lupus familiaris (dog) : TOPBP1 (DNA topoisomerase II binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Topbp1 (DNA topoisomerase II binding protein 1)
Sus scrofa (pig) : TOPBP1 (DNA topoisomerase II binding protein 1)
more info ...
Related Pseudogenes: Gm18831   Topbp1-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm389103,305,167 - 103,350,428 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379103,207,657 - 103,252,758 (+)NCBIGRCm37mm9NCBIm37
MGSCv369103,163,477 - 103,208,578 (+)NCBImm8
Celera9102,854,061 - 102,901,479 (+)NCBICelera
Cytogenetic Map9 F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Topbp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321300
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.