Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-dexrazoxane | multiple interactions | EXP | | 6480464 | Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA] | CTD | PMID:28973540 | (+)-dexrazoxane | decreases expression | EXP | | 6480464 | Dexrazoxane results in decreased expression of TOPBP1 mRNA | CTD | PMID:28973540 | (-)-demecolcine | decreases expression | ISO | RGD:1321299 | 6480464 | Demecolcine results in decreased expression of TOPBP1 mRNA | CTD | PMID:23649840 | (S)-nicotine | increases expression | ISO | RGD:1321299 | 6480464 | Nicotine results in increased expression of TOPBP1 mRNA | CTD | PMID:16949557 | 1,1-dichloroethene | increases expression | EXP | | 6480464 | vinylidene chloride results in increased expression of TOPBP1 mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TOPBP1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | affects expression | EXP | | 6480464 | Estradiol affects the expression of TOPBP1 mRNA | CTD | PMID:15598610 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TOPBP1 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TOPBP1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1562949 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TOPBP1 mRNA | CTD | PMID:22298810 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of TOPBP1 mRNA | CTD | PMID:28973697 | 5-fluorouracil | affects response to substance | ISO | RGD:1321299 | 6480464 | TOPBP1 protein affects the susceptibility to Fluorouracil | CTD | PMID:15548681 | acrylamide | increases expression | ISO | RGD:1562949 | 6480464 | Acrylamide results in increased expression of TOPBP1 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of TOPBP1 mRNA | CTD | PMID:19770486 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl 54% Chlorine results in decreased expression of TOPBP1 mRNA | CTD | PMID:23650126 | benzo[a]pyrene | decreases expression | ISO | RGD:1321299 | 6480464 | Benzoapyrene results in decreased expression of TOPBP1 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | increases methylation | ISO | RGD:1321299 | 6480464 | Benzoapyrene results in increased methylation of TOPBP1 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1321299 | 6480464 | 7 more ... | CTD | PMID:19150397, PMID:20382639 | benzo[b]fluoranthene | increases expression | EXP | | 6480464 | benzobfluoranthene results in increased expression of TOPBP1 mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | ISO | RGD:1562949 | 6480464 | bisphenol A results in decreased expression of TOPBP1 mRNA | CTD | PMID:26982218 | bisphenol A | decreases expression | ISO | RGD:1321299 | 6480464 | bisphenol A results in decreased expression of TOPBP1 mRNA | CTD | PMID:29275510 | bisphenol A | increases expression | ISO | RGD:1562949 | 6480464 | bisphenol A results in increased expression of TOPBP1 mRNA | CTD | PMID:25181051, PMID:30816183 | cadmium atom | decreases expression | ISO | RGD:1321299 | 6480464 | Cadmium results in decreased expression of TOPBP1 mRNA | CTD | PMID:21297354 | calcitriol | decreases expression | ISO | RGD:1321299 | 6480464 | Calcitriol results in decreased expression of TOPBP1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:1321299 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of TOPBP1 mRNA | CTD | PMID:21592394 | carbamazepine | affects expression | ISO | RGD:1321299 | 6480464 | Carbamazepine affects the expression of TOPBP1 mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chloroprene | increases expression | ISO | RGD:1562949 | 6480464 | Chloroprene results in increased expression of TOPBP1 mRNA | CTD | PMID:23125180 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of TOPBP1 mRNA | CTD | PMID:21151649 | cisplatin | multiple interactions | ISO | RGD:1321299 | 6480464 | [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of TOPBP1 mRNA | CTD | PMID:30871063 | copper(II) sulfate | decreases expression | ISO | RGD:1321299 | 6480464 | Copper Sulfate results in decreased expression of TOPBP1 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1321299 | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | coumestrol | increases expression | ISO | RGD:1321299 | 6480464 | Coumestrol results in increased expression of TOPBP1 mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | RGD:1321299 | 6480464 | Cyclosporine results in decreased expression of TOPBP1 mRNA | CTD | PMID:20106945, PMID:25562108 | doxorubicin | decreases expression | ISO | RGD:1562949 | 6480464 | Doxorubicin results in decreased expression of TOPBP1 mRNA | CTD | PMID:27181935 | doxorubicin | multiple interactions | ISO | RGD:1562949 | 6480464 | Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of TOPBP1 mRNA] | CTD | PMID:27181935 | Enterolactone | multiple interactions | ISO | RGD:1321299 | 6480464 | [Coumestrol co-treated with 2, 3-bis3'-hydroxybenzylbutyrolactone] results in increased expression of TOPBP1 mRNA | CTD | PMID:19167446 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of TOPBP1 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | EXP | | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TOPBP1 mRNA | CTD | PMID:22206623 | hydralazine | multiple interactions | ISO | RGD:1321299 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNA | CTD | PMID:17183730 | hypochlorous acid | decreases expression | EXP | | 6480464 | Hypochlorous Acid results in decreased expression of TOPBP1 mRNA | CTD | PMID:19376150 | idarubicin | decreases expression | EXP | | 6480464 | Idarubicin results in decreased expression of TOPBP1 mRNA | CTD | PMID:28973540 | idarubicin | multiple interactions | EXP | | 6480464 | Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA] | CTD | PMID:28973540 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of TOPBP1 mRNA | CTD | PMID:17854601 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOPBP1 mRNA] | CTD | PMID:17854601 | nicotine | increases expression | ISO | RGD:1321299 | 6480464 | Nicotine results in increased expression of TOPBP1 mRNA | CTD | PMID:16949557 | ochratoxin A | multiple interactions | ISO | RGD:1321299 | 6480464 | [ochratoxin A results in decreased acetylation of TOPBP1 promoter] which results in decreased expression of TOPBP1 mRNA | CTD | PMID:29098329 | ochratoxin A | decreases acetylation | ISO | RGD:1321299 | 6480464 | ochratoxin A results in decreased acetylation of TOPBP1 promoter | CTD | PMID:29098329 | ochratoxin A | decreases expression | ISO | RGD:1321299 | 6480464 | ochratoxin A results in decreased expression of TOPBP1 mRNA | CTD | PMID:29098329 | oxaliplatin | multiple interactions | ISO | RGD:1562949 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TOPBP1 mRNA | CTD | PMID:25729387 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of TOPBP1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1321299 | 6480464 | Acetaminophen results in increased expression of TOPBP1 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | ISO | RGD:1321299 | 6480464 | Acetaminophen results in decreased expression of TOPBP1 mRNA | CTD | PMID:21420995, PMID:29067470 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of TOPBP1 mRNA | CTD | PMID:23892564 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of TOPBP1 mRNA | CTD | PMID:23091169 | phosphoramide mustard | increases expression | ISO | RGD:1562949 | 6480464 | phosphoramide mustard results in increased expression of TOPBP1 mRNA | CTD | PMID:26708502 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of TOPBP1 mRNA | CTD | PMID:18301758 | piroxicam | decreases expression | ISO | RGD:1321299 | 6480464 | Piroxicam results in decreased expression of TOPBP1 mRNA | CTD | PMID:21858171 | resveratrol | decreases expression | ISO | RGD:1321299 | 6480464 | resveratrol results in decreased expression of TOPBP1 mRNA | CTD | PMID:15767336 | resveratrol | multiple interactions | ISO | RGD:1321299 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of TOPBP1 mRNA | CTD | PMID:19167446 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TOPBP1 mRNA | CTD | PMID:21641980 | testosterone | decreases expression | ISO | RGD:1321299 | 6480464 | Testosterone results in decreased expression of TOPBP1 mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | RGD:1321299 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of TOPBP1 mRNA | CTD | PMID:21592394 | tetrachloromethane | decreases expression | ISO | RGD:1562949 | 6480464 | Carbon Tetrachloride results in decreased expression of TOPBP1 mRNA | CTD | PMID:31150632 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of TOPBP1 mRNA | CTD | PMID:31919559 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of TOPBP1 mRNA | CTD | PMID:23557971 | topotecan | multiple interactions | ISO | RGD:1562949 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TOPBP1 mRNA | CTD | PMID:25729387 | trichostatin A | affects expression | ISO | RGD:1321299 | 6480464 | trichostatin A affects the expression of TOPBP1 mRNA | CTD | PMID:28542535 | trimellitic anhydride | increases expression | EXP | | 6480464 | trimellitic anhydride results in increased expression of TOPBP1 mRNA | CTD | PMID:19042947 | triphenyl phosphate | increases expression | ISO | RGD:1562949 | 6480464 | triphenyl phosphate results in increased expression of TOPBP1 mRNA | CTD | PMID:30589522 | troglitazone | decreases expression | ISO | RGD:1321299 | 6480464 | troglitazone results in decreased expression of TOPBP1 mRNA | CTD | PMID:19140230 | valproic acid | multiple interactions | ISO | RGD:1321299 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNA | CTD | PMID:17183730 | vancomycin | decreases expression | EXP | | 6480464 | Vancomycin results in decreased expression of TOPBP1 mRNA | CTD | PMID:18930951 | vincristine | decreases expression | ISO | RGD:1321299 | 6480464 | Vincristine results in decreased expression of TOPBP1 mRNA | CTD | PMID:23649840 | vorinostat | decreases expression | EXP | | 6480464 | Vorinostat results in decreased expression of TOPBP1 mRNA | CTD | PMID:32512035 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| 1. | Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18. |
| 2. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 3. | Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55. |
| 4. | MGD data from the GO Consortium |
| 5. | Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80. |
| 6. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 7. | RGD automated import pipeline |
| 8. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 9. | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11134256 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:14718568 | PMID:15138768 | PMID:15188402 |
| PMID:15489334 | PMID:15961388 | PMID:16141072 | PMID:16141073 | PMID:17006541 | PMID:17696610 | PMID:18799693 | PMID:20571081 | PMID:20843830 | PMID:21149450 | PMID:21267068 | PMID:21478856 |
| PMID:21482717 | PMID:21502314 | PMID:21655083 | PMID:21693576 | PMID:21873635 | PMID:22266795 | PMID:22522401 | PMID:22549958 | PMID:22922362 | PMID:23950734 | PMID:24442639 | PMID:25454945 |
| PMID:25516717 | PMID:25666521 | PMID:25703348 | PMID:26496610 | PMID:27760317 | PMID:29091030 | PMID:29114052 | PMID:30528234 | PMID:32325033 |
Genomics
