Symbol:
Topbp1
Name:
topoisomerase (DNA) II binding protein 1
Description:
ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to DNA damage stimulus (ortholog); reciprocal meiotic recombination (ortholog); response to ionizing radiation (ortholog); ASSOCIATED WITH abnormal cell cycle; abnormal cell physiology; abnormal cerebral cortex morphology; ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); FOUND IN chromosome; condensed nuclear chromosome; male germ cell nucleus; INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 17beta-estradiol
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
1110031N14Rik; 2810429C13Rik; AI256758; D430026L04Rik; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; mKIAA0259; topoisomerase (DNA) II beta binding protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TOPBP1 (DNA topoisomerase II binding protein 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Topbp1 (DNA topoisomerase II binding protein 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Topbp1 (DNA topoisomerase II binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
TOPBP1 (DNA topoisomerase II binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TOPBP1 (DNA topoisomerase II binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Topbp1 (DNA topoisomerase II binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TOPBP1 (DNA topoisomerase II binding protein 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
TOPBP1 (DNA topoisomerase II binding protein 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Rattus norvegicus (Norway rat):
Topbp1 (DNA topoisomerase II binding protein 1)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
topbp1 (DNA topoisomerase II binding protein 1)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
DPB11
Alliance
DIOPT (Hieranoid, OrthoFinder, Roundup)
Caenorhabditis elegans (roundworm):
mus-101
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
mus101
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, Roundup, TreeFam)
Related Pseudogenes:
Gm18831
Topbp1-ps1
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 103,305,167 - 103,350,428 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 103,207,657 - 103,252,758 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 103,163,477 - 103,208,578 (+) NCBI mm8 Celera 9 102,854,061 - 102,901,479 (+) NCBI Celera Cytogenetic Map 9 F1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(+)-dexrazoxane multiple interactions EXP 6480464 Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA] CTD PMID:28973540 (+)-dexrazoxane decreases expression EXP 6480464 Dexrazoxane results in decreased expression of TOPBP1 mRNA CTD PMID:28973540 (-)-demecolcine decreases expression ISO RGD:1321299 6480464 Demecolcine results in decreased expression of TOPBP1 mRNA CTD PMID:23649840 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:1562949 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TOPBP1 mRNA CTD PMID:25729387 (S)-nicotine increases expression ISO RGD:1321299 6480464 Nicotine results in increased expression of TOPBP1 mRNA CTD PMID:16949557 1,1-dichloroethene increases expression EXP 6480464 vinylidene chloride results in increased expression of TOPBP1 mRNA CTD PMID:26682919 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of TOPBP1 mRNA CTD PMID:15598610 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of TOPBP1 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TOPBP1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1562949 6480464 Tetrachlorodibenzodioxin affects the expression of TOPBP1 mRNA CTD PMID:22298810 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of TOPBP1 mRNA CTD PMID:28973697 5-fluorouracil affects response to substance ISO RGD:1321299 6480464 TOPBP1 protein affects the susceptibility to Fluorouracil CTD PMID:15548681 acrylamide increases expression ISO RGD:1562949 6480464 Acrylamide results in increased expression of TOPBP1 mRNA CTD PMID:28959563 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of TOPBP1 mRNA CTD PMID:19770486 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of TOPBP1 mRNA CTD PMID:23650126 benzo[a]pyrene decreases expression ISO RGD:1321299 6480464 Benzo(a)pyrene results in decreased expression of TOPBP1 mRNA CTD PMID:20064835 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1321299 6480464 7 more ... CTD PMID:19150397 , PMID:20382639 benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of TOPBP1 mRNA CTD PMID:26377693 bisphenol A decreases expression ISO RGD:1562949 6480464 bisphenol A results in decreased expression of TOPBP1 mRNA CTD PMID:26982218 bisphenol A decreases expression ISO RGD:1321299 6480464 bisphenol A results in decreased expression of TOPBP1 mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:1562949 6480464 bisphenol A results in increased expression of TOPBP1 mRNA CTD PMID:25181051 cadmium atom decreases expression ISO RGD:1321299 6480464 Cadmium results in decreased expression of TOPBP1 mRNA CTD PMID:21297354 calcitriol decreases expression ISO RGD:1321299 6480464 Calcitriol results in decreased expression of TOPBP1 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1321299 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TOPBP1 mRNA CTD PMID:21592394 carbamazepine affects expression ISO RGD:1321299 6480464 Carbamazepine affects the expression of TOPBP1 mRNA CTD PMID:25979313 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of TOPBP1 mRNA, Nanotubes, Carbon results in increased expression of TOPBP1 mRNA CTD PMID:25554681 chloroprene increases expression ISO RGD:1562949 6480464 Chloroprene results in increased expression of TOPBP1 mRNA CTD PMID:23125180 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of TOPBP1 mRNA CTD PMID:21151649 copper(II) sulfate decreases expression ISO RGD:1321299 6480464 Copper Sulfate results in decreased expression of TOPBP1 mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:1321299 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO RGD:1321299 6480464 Coumestrol results in increased expression of TOPBP1 mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:1321299 6480464 Cyclosporine results in decreased expression of TOPBP1 mRNA CTD PMID:20106945 , PMID:25562108 doxorubicin decreases expression ISO RGD:1562949 6480464 Doxorubicin results in decreased expression of TOPBP1 mRNA CTD PMID:27181935 doxorubicin multiple interactions ISO RGD:1562949 6480464 Fungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of TOPBP1 mRNA] CTD PMID:27181935 Enterolactone multiple interactions ISO RGD:1321299 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TOPBP1 mRNA CTD PMID:19167446 hydralazine multiple interactions ISO RGD:1321299 6480464 [Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNA CTD PMID:17183730 hypochlorous acid decreases expression EXP 6480464 Hypochlorous Acid results in decreased expression of TOPBP1 mRNA CTD PMID:19376150 idarubicin decreases expression EXP 6480464 Idarubicin results in decreased expression of TOPBP1 mRNA CTD PMID:28973540 idarubicin multiple interactions EXP 6480464 Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of TOPBP1 mRNA] CTD PMID:28973540 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of TOPBP1 mRNA CTD PMID:17854601 N-nitrosodiethylamine multiple interactions EXP 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of TOPBP1 mRNA] CTD PMID:17854601 nicotine increases expression ISO RGD:1321299 6480464 Nicotine results in increased expression of TOPBP1 mRNA CTD PMID:16949557 ochratoxin A multiple interactions ISO RGD:1321299 6480464 [ochratoxin A results in decreased acetylation of TOPBP1 promoter] which results in decreased expression of TOPBP1 mRNA CTD PMID:29098329 ochratoxin A decreases acetylation ISO RGD:1321299 6480464 ochratoxin A results in decreased acetylation of TOPBP1 promoter CTD PMID:29098329 ochratoxin A decreases expression ISO RGD:1321299 6480464 ochratoxin A results in decreased expression of TOPBP1 mRNA CTD PMID:29098329 oxaliplatin multiple interactions ISO RGD:1562949 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TOPBP1 mRNA CTD PMID:25729387 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TOPBP1 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1321299 6480464 Acetaminophen results in increased expression of TOPBP1 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1321299 6480464 Acetaminophen results in decreased expression of TOPBP1 mRNA CTD PMID:21420995 , PMID:29067470 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of TOPBP1 mRNA CTD PMID:23892564 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of TOPBP1 mRNA CTD PMID:23091169 phosphoramide mustard increases expression ISO RGD:1562949 6480464 phosphoramide mustard results in increased expression of TOPBP1 mRNA CTD PMID:26708502 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of TOPBP1 mRNA CTD PMID:18301758 piroxicam decreases expression ISO RGD:1321299 6480464 Piroxicam results in decreased expression of TOPBP1 mRNA CTD PMID:21858171 resveratrol decreases expression ISO RGD:1321299 6480464 resveratrol results in decreased expression of TOPBP1 mRNA CTD PMID:15767336 resveratrol multiple interactions ISO RGD:1321299 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of TOPBP1 mRNA CTD PMID:19167446 succimer multiple interactions EXP 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TOPBP1 mRNA CTD PMID:21641980 testosterone decreases expression ISO RGD:1321299 6480464 Testosterone results in decreased expression of TOPBP1 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:1321299 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of TOPBP1 mRNA CTD PMID:21592394 tetrachloromethane decreases expression ISO RGD:1562949 6480464 Carbon Tetrachloride results in decreased expression of TOPBP1 mRNA CTD PMID:31150632 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of TOPBP1 mRNA CTD PMID:23557971 topotecan multiple interactions ISO RGD:1562949 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TOPBP1 mRNA CTD PMID:25729387 trichostatin A affects expression ISO RGD:1321299 6480464 trichostatin A affects the expression of TOPBP1 mRNA CTD PMID:28542535 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of TOPBP1 mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:1321299 6480464 troglitazone results in decreased expression of TOPBP1 mRNA CTD PMID:19140230 valproic acid multiple interactions ISO RGD:1321299 6480464 [Hydralazine co-treated with Valproic Acid] results in decreased expression of TOPBP1 mRNA CTD PMID:17183730 vancomycin decreases expression EXP 6480464 Vancomycin results in decreased expression of TOPBP1 mRNA CTD PMID:18930951 vincristine decreases expression ISO RGD:1321299 6480464 Vincristine results in decreased expression of TOPBP1 mRNA CTD PMID:23649840 
Gene-Chemical Interaction Annotations
