Brme1 (break repair meiotic recombinase recruitment factor 1) - Rat Genome Database
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Gene: Brme1 (break repair meiotic recombinase recruitment factor 1) Mus musculus
Analyze
Symbol: Brme1
Name: break repair meiotic recombinase recruitment factor 1
RGD ID: 1314478
MGI Page MGI
Description: Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; meninges; nasal epithelium; and thoracic segment skeleton. Orthologous to human BRME1 (break repair meiotic recombinase recruitment factor 1); INTERACTS WITH aflatoxin B1 (ortholog); aflatoxin B2 (ortholog); arsane (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930432K21Rik; BRCA2 and MEILB2-associating protein 1; hypothetical protein LOC74666; Meiok21; meiotic recombination modulator; MRM; uncharacterized protein C19orf57 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,874,637 - 84,899,226 (+)NCBIGRCm39mm39
GRCm38884,148,008 - 84,172,597 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,148,025 - 84,172,590 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,671,937 - 86,696,496 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,038,264 - 87,062,695 (+)NCBImm8
Celera888,448,428 - 88,473,028 (+)NCBICelera
Cytogenetic Map8C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466305   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18287559  
PMID:18799693   PMID:21267068   PMID:21873635   PMID:32345962   PMID:32460033   PMID:32463460  


Genomics

Comparative Map Data
Brme1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,874,637 - 84,899,226 (+)NCBIGRCm39mm39
GRCm38884,148,008 - 84,172,597 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,148,025 - 84,172,590 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,671,937 - 86,696,496 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,038,264 - 87,062,695 (+)NCBImm8
Celera888,448,428 - 88,473,028 (+)NCBICelera
Cytogenetic Map8C2NCBI
BRME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1913,882,348 - 13,906,452 (-)EnsemblGRCh38hg38GRCh38
GRCh381913,882,348 - 13,906,165 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,993,168 - 14,016,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361913,854,168 - 13,877,909 (-)NCBINCBI36hg18NCBI36
Celera1913,886,915 - 13,910,654 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,564,480 - 13,588,206 (-)NCBIHuRef
CHM1_11913,993,865 - 14,017,617 (-)NCBICHM1_1
Brme1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01925,262,064 - 25,283,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,262,076 - 25,283,972 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,239,178 - 36,263,309 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,673,902 - 25,695,687 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,679,007 - 25,699,649 (-)NCBI
Celera1923,538,560 - 23,560,124 (-)NCBICelera
Cytogenetic Map19q11NCBI
Brme1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541532,652,978 - 32,667,873 (-)NCBIChiLan1.0ChiLan1.0
BRME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,174,859 - 14,197,760 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,175,306 - 14,196,501 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01913,444,811 - 13,468,748 (-)NCBIMhudiblu_PPA_v0panPan3
BRME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2048,566,525 - 48,583,329 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12048,566,165 - 48,586,951 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Brme1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366592,595,052 - 2,611,490 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,252,606 - 65,273,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,250,844 - 65,273,038 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,525,608 - 65,546,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRME1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,543,242 - 12,567,863 (-)NCBI
ChlSab1.1 Ensembl612,543,141 - 12,556,423 (-)Ensembl
Brme1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,173,110 - 1,188,664 (-)NCBI

Position Markers
D19Rat14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,150,226 - 84,150,389UniSTSGRCm38
MGSCv37886,674,125 - 86,674,288UniSTSGRCm37
Celera888,450,570 - 88,450,725UniSTS
Cytogenetic Map8C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:478
Count of miRNA genes:279
Interacting mature miRNAs:303
Transcripts:ENSMUST00000093375, ENSMUST00000118856, ENSMUST00000143833
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ560290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY296159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC507101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC510766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC532163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000093375   ⟹   ENSMUSP00000091067
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,148,252 - 84,172,589 (+)Ensembl
RefSeq Acc Id: ENSMUST00000118856   ⟹   ENSMUSP00000113651
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,148,159 - 84,172,590 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143833   ⟹   ENSMUSP00000114433
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,148,025 - 84,162,347 (+)Ensembl
RefSeq Acc Id: NM_001163752   ⟹   NP_001157224
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,874,667 - 84,899,226 (+)NCBI
GRCm38884,148,038 - 84,172,597 (+)NCBI
MGSCv37886,671,937 - 86,696,496 (+)RGD
Celera888,448,428 - 88,473,028 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_029045   ⟹   NP_083321
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,874,667 - 84,899,226 (+)NCBI
GRCm38884,148,038 - 84,172,597 (+)NCBI
MGSCv37886,671,937 - 86,696,496 (+)RGD
Celera888,448,428 - 88,473,028 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531445   ⟹   XP_006531508
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,874,637 - 84,899,220 (+)NCBI
GRCm38884,148,008 - 84,172,591 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243821   ⟹   XP_030099681
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,874,637 - 84,899,220 (+)NCBI
GRCm38884,148,008 - 84,172,591 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030243822   ⟹   XP_030099682
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39884,874,637 - 84,899,220 (+)NCBI
GRCm38884,148,008 - 84,172,591 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_083321   ⟸   NM_029045
- Peptide Label: isoform 1
- UniProtKB: Q6DIA7 (UniProtKB/Swiss-Prot),   E9QNR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157224   ⟸   NM_001163752
- Peptide Label: isoform 2
- UniProtKB: Q6DIA7 (UniProtKB/Swiss-Prot),   A0A0R4J144 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006531508   ⟸   XM_006531445
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030099681   ⟸   XM_030243821
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030099682   ⟸   XM_030243822
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000113651   ⟸   ENSMUST00000118856
RefSeq Acc Id: ENSMUSP00000114433   ⟸   ENSMUST00000143833
RefSeq Acc Id: ENSMUSP00000091067   ⟸   ENSMUST00000093375

Promoters
RGD ID:8667679
Promoter ID:EPDNEW_M11856
Type:initiation region
Name:4930432K21Rik_1
Description:Mus musculus RIKEN cDNA 4930432K21 gene , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11857  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,148,080 - 84,148,140EPDNEW
RGD ID:8667651
Promoter ID:EPDNEW_M11857
Type:multiple initiation site
Name:4930432K21Rik_2
Description:Mus musculus RIKEN cDNA 4930432K21 gene , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11856  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,148,310 - 84,148,370EPDNEW
RGD ID:6842527
Promoter ID:MM_KWN:55056
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000117424,   NM_001163752,   NM_029045,   NM_145970,   OTTMUST00000075710,   OTTMUST00000075714
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36886,671,586 - 86,672,086 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921916 AgrOrtholog
Ensembl Genes ENSMUSG00000008129 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000091067 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000113651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114433 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093375 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000118856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000143833 UniProtKB/TrEMBL
InterPro DUF4671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74666 UniProtKB/Swiss-Prot
MGD MGI:1921916 ENTREZGENE
NCBI Gene 74666 ENTREZGENE
PANTHER PTHR14583 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF4671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Brme1 PhenoGen
UniGene Mm.33625 ENTREZGENE
UniProt A0A0R4J144 ENTREZGENE
  A0A6F8PYC8_MOUSE UniProtKB/TrEMBL
  CS057_MOUSE UniProtKB/Swiss-Prot
  D3YVH8_MOUSE UniProtKB/TrEMBL
  E9QNR8 ENTREZGENE
  Q6DIA7 ENTREZGENE
UniProt Secondary A0A0R4J144 UniProtKB/Swiss-Prot
  E9QNR8 UniProtKB/Swiss-Prot
  Q9D5J2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-12 Brme1  break repair meiotic recombinase recruitment factor 1  4930432K21Rik  RIKEN cDNA 4930432K21 gene  Symbol and/or name updated 27372883 PROVISIONAL