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Gene: Was (Wiskott-Aldrich syndrome) Mus musculus
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Symbol: Was
Name: Wiskott-Aldrich syndrome
RGD ID: 1558289
Description: Exhibits identical protein binding activity. Involved in several processes, including actin filament polymerization; cellular response to interferon-gamma; and endosomal transport. Localizes to cell-cell junction; phagocytic vesicle; and vesicle membrane. Is expressed in brain; heart; liver; and spleen. Used to study IgA glomerulonephritis and Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Orthologous to human WAS (WASP actin nucleation promoting factor); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; arsenite(3-).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: U42471; W; Wasp; Wiskott-Aldrich syndrome homolog; Wiskott-Aldrich syndrome homolog (human); wiskott-Aldrich syndrome protein homolog
Orthologs:
Homo sapiens (human) : WAS (WASP actin nucleation promoting factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Was (WASP actin nucleation promoting factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Was (WASP actin nucleation promoting factor)
Pan paniscus (bonobo/pygmy chimpanzee) : WAS (WASP actin nucleation promoting factor)
Canis lupus familiaris (dog) : WAS (WASP actin nucleation promoting factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Was (WASP actin nucleation promoting factor)
Sus scrofa (pig) : WAS (WASP actin nucleation promoting factor)
Chlorocebus sabaeus (African green monkey) : WAS (WASP actin nucleation promoting factor)
Heterocephalus glaber (naked mole-rat) : Was (WASP actin nucleation promoting factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,947,705 - 7,956,730 (-)NCBI
GRCm38X8,081,466 - 8,090,491 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX8,081,453 - 8,090,498 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,658,592 - 7,667,617 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X7,238,425 - 7,247,411 (-)NCBImm8
CeleraX3,379,544 - 3,417,982 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Was
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558289
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.