Ufl1 (UFM1 specific ligase 1) - Rat Genome Database

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Gene: Ufl1 (UFM1 specific ligase 1) Mus musculus
Analyze
Symbol: Ufl1
Name: UFM1 specific ligase 1
RGD ID: 1319588
MGI Page MGI
Description: Predicted to enable UFM1 ligase activity and protein kinase binding activity. Involved in hemopoiesis; positive regulation of autophagy; and response to endoplasmic reticulum stress. Acts upstream of or within positive regulation of glial cell proliferation; regulation of gene expression; and response to L-glutamate. Located in cytoplasm and neuron projection. Is expressed in cerebellum; cerebral cortex; and liver. Orthologous to human UFL1 (UFM1 specific ligase 1); INTERACTS WITH 1,2-dimethylhydrazine; carbon nanotube; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1810074P20Rik; AI429228; E3 UFM1-protein ligase 1; E3 UFM1-protein transferase 1; Kiaa0776; Max; Maxer; mKIAA0776; multiple alpha-helix protein located at ER; Rc; Rcad; regulator of C53/LZAP and DDRGK1; RP23-35A10.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39425,247,149 - 25,281,821 (-)NCBIGRCm39mm39
GRCm39 Ensembl425,248,600 - 25,281,821 (-)Ensembl
GRCm38425,247,149 - 25,281,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl425,248,600 - 25,281,821 (-)EnsemblGRCm38mm10GRCm38
MGSCv37425,175,733 - 25,208,968 (-)NCBIGRCm37mm9NCBIm37
MGSCv36425,340,780 - 25,372,395 (-)NCBImm8
Celera424,983,514 - 25,016,784 (-)NCBICelera
Cytogenetic Map4A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:10958641   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14621295   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17208939   PMID:20228063   PMID:20531390   PMID:21267068   PMID:21494687   PMID:21677750   PMID:21873635   PMID:23152784   PMID:25952549   PMID:26496610  
PMID:28104585   PMID:30635284   PMID:30701081   PMID:30713523   PMID:31040226   PMID:32655766  


Genomics

Comparative Map Data
Ufl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39425,247,149 - 25,281,821 (-)NCBIGRCm39mm39
GRCm39 Ensembl425,248,600 - 25,281,821 (-)Ensembl
GRCm38425,247,149 - 25,281,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl425,248,600 - 25,281,821 (-)EnsemblGRCm38mm10GRCm38
MGSCv37425,175,733 - 25,208,968 (-)NCBIGRCm37mm9NCBIm37
MGSCv36425,340,780 - 25,372,395 (-)NCBImm8
Celera424,983,514 - 25,016,784 (-)NCBICelera
Cytogenetic Map4A3NCBI
UFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl696,521,595 - 96,555,276 (+)EnsemblGRCh38hg38GRCh38
GRCh38696,521,806 - 96,555,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37696,969,682 - 97,003,152 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36697,076,438 - 97,109,873 (+)NCBINCBI36hg18NCBI36
Build 34697,076,437 - 97,109,873NCBI
Celera697,611,468 - 97,644,919 (+)NCBI
Cytogenetic Map6q16.1NCBI
HuRef694,403,930 - 94,437,341 (+)NCBIHuRef
CHM1_1697,231,702 - 97,265,153 (+)NCBICHM1_1
Ufl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2538,962,721 - 38,995,134 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl538,962,171 - 38,995,199 (-)Ensembl
Rnor_6.0539,616,479 - 39,650,894 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl539,615,956 - 39,650,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0544,244,327 - 44,277,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4540,307,712 - 40,340,062 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1540,307,893 - 40,340,241 (-)NCBI
Celera537,888,662 - 37,920,107 (-)NCBICelera
Cytogenetic Map5q21NCBI
Ufl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541122,548,219 - 22,580,903 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541122,548,139 - 22,577,287 (+)NCBIChiLan1.0ChiLan1.0
UFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1698,242,689 - 98,276,146 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl698,242,756 - 98,274,377 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0694,356,440 - 94,389,920 (+)NCBIMhudiblu_PPA_v0panPan3
UFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11254,988,200 - 55,023,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1254,988,264 - 55,021,626 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1254,804,603 - 54,837,183 (+)NCBI
ROS_Cfam_1.01255,807,531 - 55,840,491 (+)NCBI
UMICH_Zoey_3.11255,142,814 - 55,175,742 (+)NCBI
UNSW_CanFamBas_1.01255,004,468 - 55,036,715 (+)NCBI
UU_Cfam_GSD_1.01255,251,683 - 55,284,623 (+)NCBI
Ufl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494689,564,693 - 89,598,140 (+)NCBI
SpeTri2.0NW_0049366991,131,385 - 1,163,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl163,638,592 - 63,700,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1163,638,589 - 63,698,931 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2172,007,561 - 72,067,762 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11377,357,239 - 77,387,385 (-)NCBI
ChlSab1.1 Ensembl1377,357,141 - 77,387,367 (-)Ensembl
Vero_WHO_p1.0NW_02366604049,653,195 - 49,682,283 (-)NCBI
Ufl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248108,804,330 - 8,832,460 (-)NCBI

Position Markers
AW551583  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38425,251,338 - 25,251,422UniSTSGRCm38
MGSCv37425,178,485 - 25,178,569UniSTSGRCm37
Celera424,986,266 - 24,986,350UniSTS
Cytogenetic Map4A3UniSTS
Whitehead/MRC_RH4437.16UniSTS
UniSTS:234879  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38425,249,077 - 25,249,284UniSTSGRCm38
MGSCv37425,176,224 - 25,176,431UniSTSGRCm37
Celera424,984,005 - 24,984,212UniSTS
Cytogenetic Map4A3UniSTS
UniSTS:234881  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38425,259,001 - 25,259,226UniSTSGRCm38
MGSCv37425,186,148 - 25,186,373UniSTSGRCm37
Celera424,993,966 - 24,994,191UniSTS
Cytogenetic Map4A3UniSTS
1810074P20Rik  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4A3UniSTS
cM Map4 UniSTS
cM Map410.59UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763365441Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261689063979Mouse
1357645Lvrq9_mliver weight QTL 9 (mouse)Not determined41789261689063979Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261689063979Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261689063979Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:740
Count of miRNA genes:434
Interacting mature miRNAs:513
Transcripts:ENSMUST00000038705, ENSMUST00000102994, ENSMUST00000132558, ENSMUST00000142949
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001355512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_026194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK007993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL365061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL935267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV274915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM900014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY097965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY368866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000038705   ⟹   ENSMUSP00000042118
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl425,250,147 - 25,281,763 (-)Ensembl
GRCm38.p6 Ensembl425,250,147 - 25,281,763 (-)Ensembl
RefSeq Acc Id: ENSMUST00000102994   ⟹   ENSMUSP00000100059
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl425,248,605 - 25,281,821 (-)Ensembl
GRCm38.p6 Ensembl425,248,605 - 25,281,821 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132558
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl425,269,149 - 25,281,748 (-)Ensembl
GRCm38.p6 Ensembl425,269,149 - 25,281,748 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142949
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl425,248,600 - 25,281,760 (-)Ensembl
GRCm38.p6 Ensembl425,248,600 - 25,281,760 (-)Ensembl
RefSeq Acc Id: NM_001355512   ⟹   NP_001342441
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39425,247,149 - 25,281,821 (-)NCBI
GRCm38425,247,149 - 25,281,821 (-)NCBI
Sequence:
RefSeq Acc Id: NM_026194   ⟹   NP_080470
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39425,247,149 - 25,281,821 (-)NCBI
GRCm38425,247,149 - 25,281,821 (-)NCBI
MGSCv37425,175,733 - 25,208,968 (-)RGD
Celera424,983,514 - 25,016,784 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080470   ⟸   NM_026194
- UniProtKB: Q8CCJ3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001342441   ⟸   NM_001355512
RefSeq Acc Id: ENSMUSP00000100059   ⟸   ENSMUST00000102994
RefSeq Acc Id: ENSMUSP00000042118   ⟸   ENSMUST00000038705

Promoters
RGD ID:6835685
Promoter ID:MM_KWN:36888
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000038705,   NM_026194,   OTTMUST00000071481,   UC008SEG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36425,208,741 - 25,209,241 (-)MPROMDB
RGD ID:6882948
Promoter ID:EPDNEW_M4925
Type:initiation region
Name:Ufl1_1
Description:Mus musculus UFM1 specific ligase 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38425,281,773 - 25,281,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914740 AgrOrtholog
Ensembl Genes ENSMUSG00000040359 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000042118 UniProtKB/Swiss-Prot
  ENSMUSP00000100059 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038705 UniProtKB/Swiss-Prot
  ENSMUST00000102994 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro E3_UFM1_ligase_1 UniProtKB/Swiss-Prot
KEGG Report mmu:67490 UniProtKB/Swiss-Prot
MGD MGI:1914740 ENTREZGENE
NCBI Gene 67490 ENTREZGENE
PANTHER PTHR31057 UniProtKB/Swiss-Prot
Pfam E3_UFM1_ligase UniProtKB/Swiss-Prot
PhenoGen Ufl1 PhenoGen
UniProt Q8CCJ3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2RSP7 UniProtKB/Swiss-Prot
  B1AXU5 UniProtKB/Swiss-Prot
  B1AXU6 UniProtKB/Swiss-Prot
  Q3V145 UniProtKB/Swiss-Prot
  Q6ZQ50 UniProtKB/Swiss-Prot
  Q8BT70 UniProtKB/Swiss-Prot
  Q8C484 UniProtKB/Swiss-Prot
  Q9D8I8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-25 Ufl1  UFM1 specific ligase 1  1810074P20Rik  RIKEN cDNA 1810074P20 gene  Symbol and/or name change 5135510 APPROVED