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ONTOLOGY REPORT - ANNOTATIONS

Term:protein destabilization
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Accession:GO:0031648 term browser browse the term
Definition:Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
Synonyms:exact_synonym: negative regulation of protein stability;   protein destabilisation


show annotations for term's descendants           Sort by:
protein destabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:96396 (PMID:15322112)		 Ensembl
RGD		 PMID:15322112 GO_REF:0000107 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase involved_in ISO (PMID:16885022) RGD PMID:16885022 NCBI chr 1:254,159,085...254,324,819
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Capn3 calpain 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:23357851)		 Ensembl
RGD		 PMID:23357851 GO_REF:0000107 NCBI chr 3:127,860,002...127,913,677
Ensembl chr 3:107,407,850...107,457,858 		JBrowse link
G Ccdc88c coiled-coil domain containing 88C involved_in ISO (PMID:14750955) RGD PMID:14750955 NCBI chr 6:125,899,337...126,019,162
Ensembl chr 6:120,169,738...120,289,555 		JBrowse link
G Cdc73 cell division cycle 73 involved_in ISO
IEA		 (PMID:18987311)
GO_REF:0000107		 RGD
Ensembl		 PMID:18987311 GO_REF:0000107 NCBI chr13:57,897,924...58,000,031
Ensembl chr13:55,357,226...55,449,656 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:9529249) RGD PMID:9529249 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains acts_upstream_of_or_within ISO (PMID:22285184) RGD PMID:22285184 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
G Clec16a C-type lectin domain containing 16A involved_in ISO (PMID:36822331) RGD PMID:36822331 NCBI chr10:4,927,799...5,123,749
Ensembl chr10:4,928,030...5,123,578 		JBrowse link
G Commd1 copper metabolism domain containing 1 acts_upstream_of_or_within ISO MGI:3714157 (PMID:17371845) RGD PMID:17371845 NCBI chr14:101,081,667...101,185,738
Ensembl chr14:96,880,463...96,984,501 		JBrowse link
G Crebbp CREB binding protein involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:24939902)		 Ensembl
UniProt
RGD		 PMID:24939902 GO_REF:0000024 GO_REF:0000107 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctsh cathepsin H involved_in ISO
ISS
IEA		 (PMID:17500053)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:17500053 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:99,488,756...99,507,639
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Cul3 cullin 3 involved_in ISO
IEA		 RNAcentral:URS00001230A0_9606 (PMID:24844779)
GO_REF:0000107		 RGD
Ensembl		 PMID:24844779 GO_REF:0000107 NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Dazap2 DAZ associated protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:33591310)		 UniProt
RGD		 PMID:33591310 GO_REF:0000024 NCBI chr 7:131,714,749...131,720,266
Ensembl chr 7:131,714,745...131,720,265 		JBrowse link
G Derl1 derlin 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:89,404,413...89,427,095
Ensembl chr 7:89,404,417...89,427,145 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:24939902) RGD PMID:24939902 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fbxl3 F-box and leucine-rich repeat protein 3 involved_in ISO (PMID:23616524) RGD PMID:23616524 NCBI chr15:86,321,504...86,341,387
Ensembl chr15:79,906,795...79,927,867 		JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO MGI:5301830 (PMID:21911473) RGD PMID:21911473 NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792 		JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 involved_in ISO (PMID:16885022) RGD PMID:16885022 NCBI chr10:17,737,181...17,834,834
Ensembl chr10:17,227,181...17,330,571 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 acts_upstream_of_or_within ISO (PMID:18625840) RGD PMID:18625840 NCBI chr 2:172,447,738...172,609,591
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:20484053) RGD PMID:20484053 NCBI chr10:101,324,378...101,342,373
Ensembl chr10:100,825,426...100,844,462 		JBrowse link
G Gsn gelsolin involved_in ISO
IEA		 (PMID:19549824)
GO_REF:0000107		 RGD
Ensembl		 PMID:19549824 GO_REF:0000107 NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Hdac6 histone deacetylase 6 involved_in ISO (PMID:24882211) RGD PMID:24882211 NCBI chr  X:17,222,538...17,244,373
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Htt huntingtin involved_in ISO
IEA		 (PMID:17947297)
GO_REF:0000107		 RGD
Ensembl		 PMID:17947297 GO_REF:0000107 NCBI chr14:80,070,456...80,219,668
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Iapp islet amyloid polypeptide involved_in ISO (PMID:22944668) RGD PMID:22944668 NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Id1 inhibitor of DNA binding 1 acts_upstream_of_or_within ISO MGI:88177 (PMID:15322112) RGD PMID:15322112 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISO (PMID:25891078) RGD PMID:25891078 NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Isoc2b isochorismatase domain containing 2b involved_in ISO (PMID:17658461) RGD PMID:17658461 NCBI chr 1:68,972,960...68,993,760
Ensembl chr 1:68,972,960...68,993,757 		JBrowse link
G Kdm8 lysine demethylase 8 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30500822)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30500822 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:189,444,527...189,459,507
Ensembl chr 1:180,020,656...180,028,841 		JBrowse link
G Klf1 KLF transcription factor 1 involved_in ISO (PMID:24139988) RGD PMID:24139988 NCBI chr19:23,250,627...23,253,802
Ensembl chr19:23,250,631...23,253,758 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:10360174), (PMID:15314173), (PMID:16479015), (PMID:18560357), (PMID:9529249) RGD PMID:9529249 PMID:10360174 PMID:15314173 PMID:16479015 PMID:18560357 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mtmr1 myotubularin related protein 1 involved_in ISO (PMID:33053349) RGD PMID:33053349 NCBI chr18:215,031...248,541
Ensembl chr18:215,089...248,541 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IEA
ISO		 GO_REF:0000107
(PMID:36608670)		 Ensembl
RGD		 PMID:36608670 GO_REF:0000107 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:24898855) RGD PMID:24898855 NCBI chr 5:155,936,112...155,945,163
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Mylip myosin regulatory light chain interacting protein involved_in ISO (PMID:19520913) RGD PMID:19520913 NCBI chr17:19,492,826...19,514,490
Ensembl chr17:19,286,650...19,308,295 		JBrowse link
G Npm1 nucleophosmin 1 acts_upstream_of_or_within ISO RGD MGI:62033 NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645
Ensembl chr  X:17,739,941...17,751,645 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:27686098)		 Ensembl
UniProt
RGD		 PMID:27686098 GO_REF:0000024 GO_REF:0000107 NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 involved_in ISO
IEA		 (PMID:18987311)
GO_REF:0000107		 RGD
Ensembl		 PMID:18987311 GO_REF:0000107 NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:96,045,958...96,073,404 		JBrowse link
G Plk1 polo-like kinase 1 involved_in ISO
IEA		 (PMID:16885022)
GO_REF:0000107		 RGD
Ensembl		 PMID:16885022 GO_REF:0000107 NCBI chr 1:186,147,658...186,157,637
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit acts_upstream_of_or_within ISO (PMID:15194694) RGD PMID:15194694 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
ISS
IEA		 (PMID:19591802), (PMID:29311685)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:19591802 PMID:29311685 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prnp prion protein involved_in ISO (PMID:20564047) RGD PMID:20564047 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein involved_in ISO (PMID:26296656) RGD PMID:26296656 NCBI chr19:40,219,235...40,225,543
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rnf139 ring finger protein 139 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:90,439,726...90,450,911
Ensembl chr 7:90,436,621...90,488,009 		JBrowse link
G Rnf5 ring finger protein 5 acts_upstream_of_or_within ISO (PMID:23093945) RGD PMID:23093945 NCBI chr20:4,150,032...4,152,593
Ensembl chr20:4,145,507...4,147,985 		JBrowse link
G Senp2 SUMO specific peptidase 2 involved_in ISO (PMID:22028379) RGD PMID:22028379 NCBI chr11:78,981,429...79,018,274
Ensembl chr11:78,981,432...79,018,238 		JBrowse link
G Serf1 small EDRK-rich factor 1 involved_in ISO (PMID:20723760), (PMID:22854022), (PMID:31034892) RGD PMID:20723760 PMID:22854022 PMID:31034892 NCBI chr 2:31,475,902...31,482,030
Ensembl chr 2:31,475,703...31,482,032 		JBrowse link
G Serf2 small EDRK-rich factor 2 involved_in ISO (PMID:20723760) RGD PMID:20723760 NCBI chr 3:128,880,681...128,884,457
Ensembl chr 3:108,426,887...108,430,724 		JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 IMP synaptophysin RGD PMID:2129524 RGD:727236 NCBI chr19:36,552,165...36,575,773
Ensembl chr19:20,378,439...20,403,808 		JBrowse link
G Sirt1 sirtuin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17936707)		 Ensembl
RGD		 PMID:17936707 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:29474172)
(PMID:20141841)		 RGD PMID:20141841 PMID:29474172 NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Snca synuclein alpha involved_in ISO
IEA		 (PMID:21320589)
GO_REF:0000107		 RGD
Ensembl		 PMID:21320589 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sox17 SRY-box transcription factor 17 involved_in ISO (PMID:17875931) RGD PMID:17875931 NCBI chr 5:19,814,345...19,819,859
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:25259869) RGD PMID:25259869 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Trim21 tripartite motif-containing 21 involved_in ISO (PMID:16880511) RGD PMID:16880511 NCBI chr 1:166,376,829...166,399,441
Ensembl chr 1:156,964,913...156,987,440 		JBrowse link
G Utp25 UTP25 small subunit processome component involved_in ISO
ISS		 (PMID:23357851)
GO_REF:0000024		 RGD
UniProt		 PMID:23357851 GO_REF:0000024 NCBI chr13:107,159,092...107,180,361
Ensembl chr13:104,630,391...104,651,662 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in ISO (PMID:26203154) RGD PMID:26203154 NCBI chr19:37,938,989...37,974,887
Ensembl chr19:21,765,749...21,801,618 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO
ISS
IEA		 (PMID:25280941)
(PMID:16461360), (PMID:25239945)
GO_REF:0000024
(PMID:24753614)
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:16461360 PMID:24753614 PMID:25239945 PMID:25280941 GO_REF:0000024 GO_REF:0000107 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  biological_process 20553
    biological regulation 13833
      regulation of biological quality 3452
        regulation of protein stability 366
          protein destabilization 57
paths to the root