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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrodotoxin
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Accession:CHEBI:9506 term browser browse the term
Definition:A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
Synonyms:exact_synonym: (1R,5R,6R,7R,9S,11R,12R,13S,14S)-14-(hydroxymethyl)-3-imino-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1(7,11).0(1,6)]tetradecane-5,9,12,13,14-pentol
 related_synonym: Formula=C11H17N3O8;   InChI=1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2-,3?,4-,5?,6-,7+,9+,10-,11+/m1/s1;   InChIKey=CFMYXEVWODSLAX-QYIGHCJRSA-N;   SMILES=OC[C@@]1(O)[C@H]2O[C@@]3(O)O[C@@H]1[C@@H]1[C@@H](O)NC(=N)N[C@]1([C@H]2O)[C@@H]3O;   TTX;   fugu poison;   maculotoxin;   octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol;   spheroidine;   tarichatoxin;   tetrodontoxin
 xref: Beilstein:4156319 "Beilstein";   CAS:4368-28-9 "ChemIDplus";   CAS:4368-28-9 "KEGG COMPOUND";   DrugBank:DB05232;   KEGG:C11692
 xref_mesh: MESH:D013779
 xref: PMID:22163187 "Europe PMC";   PMID:22412801 "Europe PMC";   PMID:22798951 "Europe PMC";   PMID:23261990 "Europe PMC";   PMID:23661608 "Europe PMC";   PMID:23866757 "Europe PMC";   PMID:23980434 "Europe PMC";   PMID:24121556 "Europe PMC";   PMID:24295175 "Europe PMC";   PMID:24566728 "Europe PMC";   PMID:28648727 "Europe PMC";   PMID:28817087 "Europe PMC";   Reaxys:6072946 "Reaxys";   Wikipedia:Tetrodotoxin


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tetrodotoxin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Camk4 calcium/calmodulin-dependent protein kinase IV JBrowse link 18 25,746,878 25,975,962 RGD:6480464
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6480464
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:6480464
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 JBrowse link 15 51,222,954 51,250,787 RGD:6480464
G Erich5 glutamate-rich 5 JBrowse link 7 73,222,331 73,243,684 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gnrh1 gonadotropin releasing hormone 1 JBrowse link 15 44,441,856 44,446,064 RGD:6480464
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:6480464
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:6480464
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:6480464
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Kcnc1 potassium voltage-gated channel subfamily C member 1 JBrowse link 1 102,414,352 102,456,718 RGD:6480464
G Kcnc2 potassium voltage-gated channel subfamily C member 2 JBrowse link 7 54,978,453 55,159,362 RGD:6480464
G Kiss1 KiSS-1 metastasis-suppressor JBrowse link 13 50,529,506 50,537,603 RGD:6480464
G Kiss1r KISS1 receptor JBrowse link 7 12,606,210 12,609,868 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:6480464
G Npy neuropeptide Y JBrowse link 4 79,557,856 79,565,059 RGD:6480464
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6480464
G Pvalb parvalbumin JBrowse link 7 119,428,657 119,443,674 RGD:6480464
G Rhbdl2 rhomboid like 2 JBrowse link 5 141,462,579 141,511,893 RGD:6480464
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:6480464
G Scn2a sodium voltage-gated channel alpha subunit 2 JBrowse link 3 51,687,910 51,822,008 RGD:6480464
G Scn2b sodium voltage-gated channel beta subunit 2 JBrowse link 8 49,419,003 49,431,110 RGD:6480464
G Scn3a sodium voltage-gated channel alpha subunit 3 JBrowse link 3 51,530,897 51,643,140 RGD:6480464
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:6480464
G Scn8a sodium voltage-gated channel alpha subunit 8 JBrowse link 7 142,575,629 142,683,659 RGD:6480464
G Scn9a sodium voltage-gated channel alpha subunit 9 JBrowse link 3 52,583,953 52,664,209 RGD:6480464
G Sct secretin JBrowse link 1 214,264,865 214,277,437 RGD:6480464
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:6480464
G Tcf25 transcription factor 25 JBrowse link 19 56,178,905 56,213,299 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          neurotoxin 17275
            tetrodotoxin 42
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heterobicyclic compound 15889
                                      quinazolines 444
                                        quinazoline alkaloid 42
                                          tetrodotoxin 42
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.