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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Arc |
activity-regulated cytoskeleton-associated protein |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of ARC mRNA] |
CTD |
PMID:25945544 |
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NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO EXP |
Tetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]; Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA] 3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamide promotes the reaction [Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]]; Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]] Tetrodotoxin inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]; Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA] |
CTD |
PMID:16166269 PMID:18184782 PMID:26095976 |
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NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] |
CTD |
PMID:17973980 |
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NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
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G |
Chrna7 |
cholinergic receptor nicotinic alpha 7 subunit |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] |
CTD |
PMID:18321476 |
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NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
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NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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G |
Crh |
corticotropin releasing hormone |
decreases activity |
ISO |
Tetrodotoxin results in decreased activity of CRH protein |
CTD |
PMID:12906840 |
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NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
[Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; [Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein] |
CTD |
PMID:24070585 |
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NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] |
CTD |
PMID:17973980 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
EXP |
[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of CYP3A9 mRNA |
CTD |
PMID:22341215 |
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NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of EGR1 mRNA] |
CTD |
PMID:25945544 |
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NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
Entpd4 |
ectonucleoside triphosphate diphosphohydrolase 4 |
multiple interactions |
EXP |
[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of ENTPD4 mRNA |
CTD |
PMID:22341215 |
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NCBI chr15:51,222,954...51,250,787
Ensembl chr15:51,222,954...51,250,787
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G |
Erich5 |
glutamate-rich 5 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of ERICH5 mRNA |
CTD |
PMID:26436198 |
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NCBI chr 7:73,222,331...73,243,684
Ensembl chr 7:73,222,730...73,242,899
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of FOS mRNA; Tetrodotoxin results in decreased expression of FOS protein |
CTD |
PMID:7534335 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Gnrh1 |
gonadotropin releasing hormone 1 |
decreases secretion |
ISO |
Tetrodotoxin results in decreased secretion of GNRH1 protein |
CTD |
PMID:28731686 |
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NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875 Ensembl chr15:44,442,555...44,442,875
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
increases localization multiple interactions |
EXP |
Tetrodotoxin results in increased localization of GRIA1 protein [Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein] |
CTD |
PMID:19674091 PMID:29939358 |
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NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
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G |
Gria2 |
glutamate ionotropic receptor AMPA type subunit 2 |
increases localization multiple interactions increases expression |
EXP ISO |
Tetrodotoxin results in increased localization of GRIA2 protein [Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein] Tetrodotoxin results in increased expression of GRIA2 protein Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIA2 protein] |
CTD |
PMID:19674091 PMID:25945544 PMID:29939358 |
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NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2A protein] |
CTD |
PMID:25945544 |
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NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2B protein] |
CTD |
PMID:25945544 |
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NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein] |
CTD |
PMID:16300829 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Kcnc1 |
potassium voltage-gated channel subfamily C member 1 |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of KCNC1 mRNA |
CTD |
PMID:18775767 |
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NCBI chr 1:102,414,352...102,456,718
Ensembl chr 1:102,414,625...102,456,411
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G |
Kcnc2 |
potassium voltage-gated channel subfamily C member 2 |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of KCNC2 mRNA; Tetrodotoxin results in decreased expression of KCNC2 protein |
CTD |
PMID:18775767 |
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NCBI chr 7:54,978,453...55,159,362
Ensembl chr 7:54,980,120...55,159,351
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G |
Kiss1 |
KiSS-1 metastasis-suppressor |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] |
CTD |
PMID:18948403 |
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NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389
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G |
Kiss1r |
KISS1 receptor |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] |
CTD |
PMID:18948403 |
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NCBI chr 7:12,606,210...12,609,868
Ensembl chr 7:12,606,210...12,609,868
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO EXP |
Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein] Tetrodotoxin results in decreased phosphorylation of MAPK1 protein Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:15086530 PMID:30205134 PMID:30940546 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO EXP |
Tetrodotoxin results in decreased phosphorylation of MAPK3 protein Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK3 protein] Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15086530 PMID:30205134 PMID:30940546 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Masp2 |
mannan-binding lectin serine peptidase 2 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of MASP2 mRNA |
CTD |
PMID:26436198 |
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NCBI chr 5:165,415,105...165,429,857
Ensembl chr 5:165,415,136...165,430,054
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G |
Npy |
neuropeptide Y |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of NPY mRNA] |
CTD |
PMID:2233698 |
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NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
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G |
Prkcb |
protein kinase C, beta |
multiple interactions |
EXP |
[Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA |
CTD |
PMID:22341215 |
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NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
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G |
Pvalb |
parvalbumin |
decreases expression |
EXP |
Tetrodotoxin results in decreased expression of PVALB mRNA |
CTD |
PMID:18775767 |
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NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
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G |
Rhbdl2 |
rhomboid like 2 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of RHBDL2 mRNA |
CTD |
PMID:26436198 |
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NCBI chr 5:141,462,579...141,511,893
Ensembl chr 5:141,491,223...141,507,892
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G |
Scn1b |
sodium voltage-gated channel beta subunit 1 |
multiple interactions |
EXP |
Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]; Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] |
CTD |
PMID:9236205 PMID:21983428 |
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NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
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G |
Scn2a |
sodium voltage-gated channel alpha subunit 2 |
multiple interactions decreases activity |
EXP ISO |
Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein] Tetrodotoxin results in decreased activity of SCN2A protein Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA] |
CTD |
PMID:9236205 PMID:22972919 PMID:25358543 |
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NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
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G |
Scn2b |
sodium voltage-gated channel beta subunit 2 |
multiple interactions |
EXP |
Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] |
CTD |
PMID:21983428 |
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NCBI chr 8:49,419,003...49,431,110
Ensembl chr 8:49,418,965...49,427,689
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G |
Scn3a |
sodium voltage-gated channel alpha subunit 3 |
multiple interactions |
ISO |
Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN3A mRNA] |
CTD |
PMID:25358543 |
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NCBI chr 3:51,530,897...51,643,140
Ensembl chr 3:51,532,627...51,643,140
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G |
Scn5a |
sodium voltage-gated channel alpha subunit 5 |
decreases activity |
EXP |
Tetrodotoxin results in decreased activity of SCN5A protein |
CTD |
PMID:17978865 |
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NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
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G |
Scn8a |
sodium voltage-gated channel alpha subunit 8 |
multiple interactions decreases activity |
ISO EXP |
[Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCN8A protein]; Tetrodotoxin inhibits the reaction [SCN8A protein results in increased transport of Sodium] Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] Tetrodotoxin results in decreased activity of SCN8A protein |
CTD |
PMID:16020462 PMID:17522141 PMID:21983428 PMID:23382806 PMID:24070585 |
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NCBI chr 7:142,575,629...142,683,659
Ensembl chr 7:142,575,672...142,684,114
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G |
Scn9a |
sodium voltage-gated channel alpha subunit 9 |
decreases activity multiple interactions |
ISO |
Tetrodotoxin results in decreased activity of SCN9A protein [Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin inhibits the reaction [SCN9A protein results in increased transport of Sodium] |
CTD |
PMID:16020462 PMID:17522141 PMID:23382806 |
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NCBI chr 3:52,583,953...52,664,209
Ensembl chr 3:52,583,951...52,664,209
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G |
Sct |
secretin |
multiple interactions |
EXP |
Tetrodotoxin inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein] |
CTD |
PMID:15963647 PMID:16888165 |
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NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
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G |
Slc9a1 |
solute carrier family 9 member A1 |
multiple interactions |
ISO |
[cariporide co-treated with Tetrodotoxin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein] |
CTD |
PMID:24070585 |
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NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
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G |
Tcf25 |
transcription factor 25 |
increases expression |
ISO |
Tetrodotoxin results in increased expression of TCF25 mRNA |
CTD |
PMID:26436198 |
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NCBI chr19:56,178,905...56,213,299
Ensembl chr19:56,179,111...56,213,310
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
cariporide promotes the reaction [Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Tetrodotoxin inhibits the reaction [decamethrin results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [Permethrin results in increased secretion of TNF protein]; Tetrodotoxin promotes the reaction [cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]] |
CTD |
PMID:24070585 PMID:27655349 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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