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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinazoline alkaloid
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Accession:CHEBI:36470 term browser browse the term
Definition:Any alkaloid based on a quinazoline skeleton and its substituted derivatives.
Synonyms:related_synonym: quinazoline alkaloids



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Anhydrotetrodotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn8a sodium voltage-gated channel alpha subunit 8 decreases activity ISO anhydrotetrodotoxin results in decreased activity of SCN8A protein CTD PMID:17522141 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:133,861,227...134,030,026
JBrowse link
tetrodotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions EXP Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]
Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]; Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP protein]
CTD PMID:35946953 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions ISO Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of ARC mRNA] CTD PMID:25945544 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:108,444,692...108,451,220
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP
Tetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]; Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA]
Tetrodotoxin inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]; Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]
3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamide promotes the reaction [Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]]; Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]
CTD PMID:16166269 PMID:18184782 PMID:26095976 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions EXP Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] CTD PMID:17973980 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,857,146...25,077,193
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] CTD PMID:18321476 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Crh corticotropin releasing hormone decreases activity ISO Tetrodotoxin results in decreased activity of CRH protein CTD PMID:12906840 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO [Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; [Tetrodotoxin co-treated with cariporide] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB mRNA]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CYBB protein] CTD PMID:24070585 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Tetrodotoxin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions EXP [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of CYP3A9 mRNA CTD PMID:22341215 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in increased expression of EGR1 mRNA] CTD PMID:25945544 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 multiple interactions EXP [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of ENTPD4 mRNA CTD PMID:22341215 NCBI chr15:44,630,878...44,658,654
Ensembl chr15:51,040,673...51,068,441
JBrowse link
G Erich5 glutamate-rich 5 increases expression ISO Tetrodotoxin results in increased expression of ERICH5 mRNA CTD PMID:26436198 NCBI chr 7:65,655,829...65,682,221
Ensembl chr 7:67,536,588...67,563,989
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Tetrodotoxin results in decreased expression of FOS mRNA; Tetrodotoxin results in decreased expression of FOS protein CTD PMID:7534335 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 decreases secretion ISO Tetrodotoxin results in decreased secretion of GNRH1 protein CTD PMID:28731686 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases localization
multiple interactions
increases expression
EXP Tetrodotoxin results in increased localization of GRIA1 protein
[Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein]
tetrodotoxin increases expression of Gria1 protein in nucleus accumbens cultured cells
CTD
RGD
PMID:19674091 PMID:29939358 PMID:19674091 RGD:4107725 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases localization
multiple interactions
increases expression
increases expression
EXP
ISO
Tetrodotoxin results in increased localization of GRIA2 protein
Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIA2 protein]
Tetrodotoxin results in increased expression of GRIA2 protein
[Lead co-treated with Tetrodotoxin] results in increased expression of [GRIA1 protein binds to GRIA2 protein]
tetrodotoxin increases expression of Gria2 protein in nucleus accumbens cultured cells
CTD
RGD
PMID:19674091 PMID:25945544 PMID:29939358 PMID:19674091 RGD:4107725 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2A protein] CTD PMID:25945544 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions ISO Tetrodotoxin inhibits the reaction [ciguatoxin 3C results in decreased expression of GRIN2B protein] CTD PMID:25945544 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Tetrodotoxin inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein] CTD PMID:16300829 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Kcnc1 potassium voltage-gated channel subfamily C member 1 decreases expression EXP Tetrodotoxin results in decreased expression of KCNC1 mRNA CTD PMID:18775767 NCBI chr 1:106,039,247...106,081,034
Ensembl chr 1:106,039,237...106,081,033
JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 decreases expression EXP Tetrodotoxin results in decreased expression of KCNC2 mRNA; Tetrodotoxin results in decreased expression of KCNC2 protein CTD PMID:18775767 NCBI chr 7:49,586,274...49,770,212
Ensembl chr 7:49,586,136...49,770,212
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor multiple interactions ISO Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] CTD PMID:18948403 NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906
JBrowse link
G Kiss1r KISS1 receptor multiple interactions ISO Tetrodotoxin inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]; Tetrodotoxin promotes the reaction [2-aminoethyl diphenylborinate inhibits the reaction [[KISS1 protein results in increased activity of KISS1R protein] which results in increased abundance of Calcium]] CTD PMID:18948403 NCBI chr 7:10,435,766...10,439,424
Ensembl chr 7:10,435,766...10,439,424
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK1 protein]
Tetrodotoxin results in decreased phosphorylation of MAPK1 protein
Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK1 protein]
CTD PMID:15086530 PMID:30205134 PMID:30940546 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO
EXP
Tetrodotoxin results in decreased phosphorylation of MAPK3 protein
Tetrodotoxin inhibits the reaction [Permethrin results in increased phosphorylation of MAPK3 protein]
Tetrodotoxin inhibits the reaction [Bmk NT1 toxin, Buthus martensii Karsch results in increased phosphorylation of MAPK3 protein]
CTD PMID:15086530 PMID:30205134 PMID:30940546 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Masp2 MBL associated serine protease 2 increases expression ISO Tetrodotoxin results in increased expression of MASP2 mRNA CTD PMID:26436198 NCBI chr 5:164,319,017...164,332,686
Ensembl chr 5:164,308,991...164,332,705
JBrowse link
G Npy neuropeptide Y multiple interactions EXP Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of NPY mRNA] CTD PMID:2233698 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA CTD PMID:22341215 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740
JBrowse link
G Pvalb parvalbumin decreases expression EXP Tetrodotoxin results in decreased expression of PVALB mRNA CTD PMID:18775767 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:111,653,111...111,668,446
JBrowse link
G Rhbdl2 rhomboid like 2 increases expression ISO Tetrodotoxin results in increased expression of RHBDL2 mRNA CTD PMID:26436198 NCBI chr 5:136,037,560...136,081,970
Ensembl chr 5:141,322,354...141,366,747
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 multiple interactions EXP Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]; Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] CTD PMID:9236205 PMID:21983428 NCBI chr 1:95,481,298...95,491,211
Ensembl chr 1:95,481,298...95,491,197
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 multiple interactions
decreases activity
EXP
ISO
Tetrodotoxin results in decreased activity of [SCN2A protein binds to SCN1B protein]
Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN2A mRNA]
Tetrodotoxin results in decreased activity of SCN2A protein
CTD PMID:9236205 PMID:22972919 PMID:25358543 NCBI chr 3:70,710,862...70,845,569
Ensembl chr 3:70,710,954...70,845,279
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 multiple interactions EXP Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein] CTD PMID:21983428 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:54,322,383...54,334,519
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 multiple interactions ISO Tetrodotoxin inhibits the reaction [decamethrin results in decreased expression of SCN3A mRNA] CTD PMID:25358543 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:70,556,224...70,666,198
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity EXP Tetrodotoxin results in decreased activity of SCN5A protein CTD PMID:17978865 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:128,098,613...128,196,470
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 multiple interactions
decreases activity
ISO
EXP
[Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCN8A protein]; Tetrodotoxin inhibits the reaction [SCN8A protein results in increased transport of Sodium]
Tetrodotoxin results in decreased activity of SCN8A protein
Tetrodotoxin results in decreased activity of [SCN8A protein binds to SCN1B protein binds to SCN2B protein]
CTD PMID:16020462 PMID:17522141 PMID:21983428 PMID:23382806 PMID:24070585 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:133,861,227...134,030,026
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 decreases activity
multiple interactions
ISO Tetrodotoxin results in decreased activity of SCN9A protein
[Tetrodotoxin results in decreased activity of [SCN8A protein co-treated with SCN9A protein]] which affects the transport of Sodium; Tetrodotoxin inhibits the reaction [SCN9A protein results in increased transport of Sodium]
CTD PMID:16020462 PMID:17522141 PMID:23382806 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:71,553,189...71,701,377
JBrowse link
G Sct secretin multiple interactions EXP Tetrodotoxin inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein] CTD PMID:15963647 PMID:16888165 NCBI chr 1:205,812,435...205,813,246
Ensembl chr 1:205,812,435...205,813,246
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions ISO [cariporide co-treated with Tetrodotoxin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein] CTD PMID:24070585 NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:150,860,228...150,913,517
JBrowse link
G Tcf25 TCF25 ribosome quality control complex subunit increases expression ISO Tetrodotoxin results in increased expression of TCF25 mRNA CTD PMID:26436198 NCBI chr19:68,323,789...68,358,226
Ensembl chr19:68,323,867...68,358,240
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cariporide promotes the reaction [Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; Tetrodotoxin inhibits the reaction [decamethrin results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Tetrodotoxin inhibits the reaction [Permethrin results in increased secretion of TNF protein]; Tetrodotoxin promotes the reaction [cariporide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]] CTD PMID:24070585 PMID:27655349 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            alkaloid 8073
              quinazoline alkaloid 43
                (+/-)-tetrodotoxin 0
                (11S,13S)-3-Amino-5,12,13,14-tetrahydroxy-14-(hydroxymethyl)-8,10-dioxa-2-aza-4-azoniatetracyclo[7.3.1.17,11.01,6]tetradec-3-en-9-olate 0
                (11s,13s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 0
                Anhydrotetrodotoxin 1
                asperlicins + 0
                chrysogine 0
                penipanoid C 0
                tetrodotoxin + 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteropolycyclic compound 18651
                                    organic heterobicyclic compound 17545
                                      quinazolines 578
                                        quinazoline alkaloid 43
                                          (+/-)-tetrodotoxin 0
                                          (11S,13S)-3-Amino-5,12,13,14-tetrahydroxy-14-(hydroxymethyl)-8,10-dioxa-2-aza-4-azoniatetracyclo[7.3.1.17,11.01,6]tetradec-3-en-9-olate 0
                                          (11s,13s)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol 0
                                          Anhydrotetrodotoxin 1
                                          asperlicins + 0
                                          chrysogine 0
                                          penipanoid C 0
                                          tetrodotoxin + 43
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