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Gene: Entpd4 (ectonucleoside triphosphate diphosphohydrolase 4) Rattus norvegicus

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Symbol:

Entpd4

Name:

ectonucleoside triphosphate diphosphohydrolase 4

RGD ID:

1309511

Description:

Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleobase-containing small molecule metabolic process. Predicted to be located in Golgi membrane and autophagosome membrane. Predicted to be active in Golgi apparatus and membrane. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC361063

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	51,040,665 - 51,068,450 (+)	NCBI		GRCr8
mRatBN7.2	15	44,630,878 - 44,658,654 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	44,630,873 - 44,658,706 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	48,748,781 - 48,776,557 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	49,860,278 - 49,888,054 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	46,719,607 - 46,747,383 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	51,222,954 - 51,250,787 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	51,222,954 - 51,250,787 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	54,952,393 - 54,980,226 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	49,928,874 - 49,956,707 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	49,954,416 - 49,971,502 (+)	NCBI
Celera	15	44,313,639 - 44,341,471 (+)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Conotruncal Cardiac Defects (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

Aroclor 1254 (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bupivacaine (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (EXP,ISO)

Dibutyl phosphate (ISO)

diclofenac (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

fenthion (ISO)

fenvalerate (EXP)

folic acid (ISO)

fructose (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

hydrogen peroxide (ISO)

indometacin (EXP,ISO)

methylparaben (ISO)

nefazodone (EXP)

nickel dichloride (ISO)

paracetamol (EXP)

PCB138 (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

SB 431542 (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

tetrodotoxin (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CTP metabolic process (IBA,ISO)

GDP catabolic process (ISO)

nucleobase-containing small molecule catabolic process (ISO)

UDP catabolic process (IBA,ISO)

Cellular Component

autophagosome membrane (ISO)

Golgi apparatus (IBA)

Golgi membrane (ISO)

membrane (IBA,IEA)

Molecular Function

ATP binding (IEA)

CDP phosphatase activity (ISO)

CTPase activity (ISO)

GDP phosphatase activity (IBA,ISO)

hydrolase activity (IEA)

nucleoside diphosphate phosphatase activity (ISO)

nucleotide binding (IEA)

protein binding (ISO)

ribonucleoside triphosphate phosphatase activity (IBA,ISO)

UDP phosphatase activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9556635	PMID:10393803

Genomics

Comparative Map Data

Entpd4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	51,040,665 - 51,068,450 (+)	NCBI		GRCr8
mRatBN7.2	15	44,630,878 - 44,658,654 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	44,630,873 - 44,658,706 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	48,748,781 - 48,776,557 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	49,860,278 - 49,888,054 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	46,719,607 - 46,747,383 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	51,222,954 - 51,250,787 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	51,222,954 - 51,250,787 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	54,952,393 - 54,980,226 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	49,928,874 - 49,956,707 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	49,954,416 - 49,971,502 (+)	NCBI
Celera	15	44,313,639 - 44,341,471 (+)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

ENTPD4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	23,429,162 - 23,457,647 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	23,385,783 - 23,457,695 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	23,286,675 - 23,315,160 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	23,346,075 - 23,376,624 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	23,346,095 - 23,371,081	NCBI
Celera	8	22,252,129 - 22,277,803 (-)	NCBI		Celera
Cytogenetic Map	8	p21.3	NCBI
HuRef	8	21,832,046 - 21,852,898 (-)	NCBI		HuRef
CHM1_1	8	23,488,792 - 23,517,371 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	23,704,046 - 23,732,531 (-)	NCBI		T2T-CHM13v2.0

Entpd4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	69,574,600 - 69,604,191 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	69,574,623 - 69,604,719 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	69,337,151 - 69,366,742 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	69,337,174 - 69,367,270 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	69,955,208 - 69,984,799 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	68,290,515 - 68,320,017 (+)	NCBI		MGSCv36	mm8
Celera	14	67,110,551 - 67,140,190 (+)	NCBI		Celera
Cytogenetic Map	14	D2	NCBI
cM Map	14	36.05	NCBI

Entpd4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	46,609,211 - 46,637,643 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	46,609,211 - 46,637,622 (-)	NCBI	ChiLan1.0	ChiLan1.0

ENTPD4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	41,933,879 - 41,962,551 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	17,661,114 - 17,689,788 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	22,678,746 - 22,707,408 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	19,614,384 - 19,635,250 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	19,571,337 - 19,635,150 (-)	Ensembl	panpan1.1		panPan2

ENTPD4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	34,032,104 - 34,067,772 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	34,032,055 - 34,063,281 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	34,620,798 - 34,656,442 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	34,239,828 - 34,275,466 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	34,239,830 - 34,321,447 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	34,186,191 - 34,221,827 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	34,040,507 - 34,076,213 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	34,195,642 - 34,231,581 (+)	NCBI		UU_Cfam_GSD_1.0

Entpd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	11,650,183 - 11,673,850 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936555	6,893,393 - 6,919,584 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936555	6,896,661 - 6,920,333 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENTPD4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	7,565,604 - 7,594,057 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	7,565,610 - 7,604,464 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	8,429,640 - 8,457,467 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ENTPD4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	21,528,520 - 21,574,330 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	21,543,888 - 21,574,311 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	20,646,740 - 20,692,640 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Entpd4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	18,670,041 - 18,697,619 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	18,670,609 - 18,697,594 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Entpd4
27 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	112
Count of miRNA genes:	96
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000064428
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	28030665	82262678	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	33611058	71477291	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	33611058	71477291	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	28030665	82262678	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	40631268	98288169	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	27885774	86257085	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	34054139	79054139	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	28030665	82262678	Rat
2306968	Anxrr23	Anxiety related response QTL 23	4.83		reflex trait (VT:0001961)	amplitude of the acoustic startle response (CMO:0001520)	15	40631268	46187442	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	28030665	82262678	Rat
7411725	Strs7	Sensitivity to stroke QTL 7	3.8		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	15	40289901	49308583	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001401664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000064428 ⟹ ENSRNOP00000063756

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	44,630,873 - 44,658,706 (+)	Ensembl
Rnor_6.0 Ensembl	15	51,222,954 - 51,250,787 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088928 ⟹ ENSRNOP00000070148

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	44,630,907 - 44,658,648 (+)	Ensembl
Rnor_6.0 Ensembl	15	51,222,984 - 51,250,754 (+)	Ensembl

RefSeq Acc Id:

NM_001401664 ⟹ NP_001388593

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	51,040,674 - 51,068,450 (+)	NCBI
mRatBN7.2	15	44,630,878 - 44,658,654 (+)	NCBI

RefSeq Acc Id:

NM_001401665 ⟹ NP_001388594

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	51,040,674 - 51,068,450 (+)	NCBI
mRatBN7.2	15	44,630,878 - 44,658,654 (+)	NCBI

RefSeq Acc Id:

XM_006252276 ⟹ XP_006252338

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	51,040,701 - 51,068,449 (+)	NCBI
mRatBN7.2	15	44,631,341 - 44,658,653 (+)	NCBI
Rnor_6.0	15	51,223,114 - 51,250,735 (+)	NCBI
Rnor_5.0	15	54,952,393 - 54,980,226 (+)	NCBI

Sequence:

show sequence

CGGGGTCCGGAGGGGTGAGGGCAGCGGGAGGCCACGGCCCTGTCCAACCGACTCCCTCGCCATA
TCCGGGCGCCCCGCCGCACCCCCGTGACCCCGGTGACAGGTGCTTGTCCCCGACACCTTGCCGG
GTCCCGGGAGCGCCCTGACCCCATGGCGAGTGTGGGCTGAGGGAGAAGGACTATTGATCCCGGG
GCTGGATGGCCTCTGCCTGCCTCCCGAAATCTGACGACGACGCATGTAGCATCACGTATTTGCT
TTGCTCTGCGCTTTGGGGAAGTTTCCTGTTAGAATCCCCCGTGGAAAAAATGTGGCGGAACGGG
AGATCAGCGATGGTGCACGGTTGTCTTTCTCAACTTGAGTCATGCGTAGACTCTTTTTAAAGGG
ACAAGTCTCCCATTCTCAGGAATATAACTCCAGAACCTGCAGGGCGCCTCAGACCCCAGCTAGG
TGAACACAGGTGCTGAGACCATTTGTCACCAGGAAACAAAAGAGATGATGCTACTCTCTGTTGA
TGTTTGTTATAATTCAAGACCTGCATGTTACATAGTAAACTAGAGGGTAGCTCTGACTCCATGA
AGACCCCAGCTCCGATTCTGTCATTGTAGATGACGAGAACTGAATCCCACAACATTGCCTGGAC
CTTGCTTGGCCTTTCAGTATGGGGAGGATTGGCATTTCCTGTCTCTTTCCTGCTTCTTGGCATT
TTAGCATCTCGCCAGTGGGCTGTCCTCGAATTCTGAACACCAATTTACGACAAATCGTTGTCAT
TAGCATCCTGGCTGCAGCTGTCTCCCTTTTATACTTTTCTGTTGTCATAATCCGCAGCAAGTAT
GGGTGGCTGTCAAAGGACAAGAAATTTCAAAGGTACTTGGCCCGAGTCACAGACGTTGAGGCTA
CAGACACCAACAACCCCAACGTGAACTATGGCATTGTGGTGGACTGCGGCAGTAGTGGGTCTCG
GATATTTGTCTATTGCTGGCCTCAGCACAACGGCAATCCTCATGACCTGCTGGACATCAGACAG
ATGAGGGACAAAAACCGGAAGCCAGTGGTGATGAAAATTAAGCCCGGCATTTCAGAGTTTGCTA
CCTCTCCAGAAAAAGTCAGCGATTACATCTCTCCGCTTCTGAGCTTTGCTGCAGAACATGTGCC
TCGGGCAAAACACAAAGAGACACCTCTCTATATCCTCTGCACAGCCGGGATGAGAGTCCTTCCT
GAAAGCCAGCAGAAAGCCATCCTGGAGGATCTCCTGACCGACATCCCTGTGCACTATGACTTCT
TGTTTTCTGACTCCCATGCCGAAGTCATCTCAGGAAAACAGGAAGGTGTGTATGCTTGGATTGG
CATTAATTTTGTCCTTGGACGGTTTGAGCATATTGAGGAGGATGATGAGGCAGTTGTGGAAGTC
AACATTCCTGGCAGTGAGAGCAGCGAGGCCATCGTGCGGAAAAGGACAGCCGGTATTCTTGACA
TGGGAGGCGTGTCTACCCAGATAGCATACGAAGTCCCCAAAACTGTAAGCTTTGCCTCCTCACA
GCAGGAAGAAGTAGCTAAAAACTTATTAGCTGAATTCAACTTGGGGTGTGATGTCCACCAGACT
GAGCATGTGTACCGCGTCTATGTGGCCACATTTCTTGGGTTTGGTGGTAATGCTGCTCGGCAGA
GATATGAAGACAGACTATTTGCCAGCACAGTTCAGAAAAACAGGCTTCTGGGTAAACAGACTGG
CCTGACTCCTGATGCTCCATTTCTGGACCCCTGCTTGCCTCTGGACCTTAAAGATGAGATCCAG
CAAAATGGGCAAACCCTGTACCTTCGGGGGACAGGAGACTTCGACCTGTGTCGAGAGACCCTCC
AGCCTTTCATGAACAAAACCAATGAGACACAGACTTCTCTCAATGGAGTCTACCAGCCTCCAAT
CCACTTCCAGAACAGTGAATTCTATGGCTTCTCTGAGTTCTACTATTGCACCGAAGATGTCTTA
CGAATGGGGGGAGACTACAATGCTGCTAAATTTACTAAAGCTGCCAAGGATTACTGTGCAACAA
AGTGGTCGATCTTGCGGGAACGCTTTGACCGAGGACTGTACGCCTCTCATGCCGACCTCCATCG
ACTTAAGTATCAGTGTTTCAAATCAGCCTGGATGTTTGAGGTGTTCCACAGGGGCTTCTCCTTC
CCTGTCACATACAAAAGTCTGAAGACAGCCTTGCAGGTGTATGACAAGGAAGTGCAGTGGACCC
TGGGGGCAATCCTTTACAGGACCCGCTTTCTGCCCTTGAGAGACATCCGACAGGAGGTGTTCCG
GGCTGGCCATGCACACTGGCAGGGCGTGTCCTTTGTCTACAACCACTATCTGTTCTCTGGTTGC
TTCCTGGTCGTCCTTCTATCCATCCTTCTCTACCTGCTGCGGCTTCGGCGCATCCACCGCAGGG
CACCCCGCACTGGCTCTCTGTGGATGGAGGAAGGCCTGCCCTCCCAGAAGGGCCCTGGGCCCTT
GTGACAGACACTGTGTCAGCTTGAAGAAGACTCTACAGGAAAAGCCATTTTTGCCTCAGGGTTT
CTCATATGCTCCAATTGTTTTGTTTGTCCCTTTCCTTTCTGTTACAAAACCCCACTGATTTGTA
AACCCTGCTGTCTAGAGGTACTACCATTTTGAACGCAGCTTAAAATGGAGGAGTGGAAAAGAGA
CTTCACTCAGCTTGTGCTGCACAGCATCTGCCACACATCAGTAAGGTTTGTAGGAAGTGCTGCA
TTTTTAGCACATGCACTTGGGTACATGCACAAGGGGACAGTGGGCAAGTTCCCATCAGCGTAGA
TGGAACTTCAGAGTGGTCCTGGGACAGAACCAAGCTGTGAGTTTTACCCTCTTTCCTCTCCAAA
CACCTCAAGCTAGAAGGGGGGCGTTTGATTTTATTTGCTGCTCAGGTCTGTCACCATCTGTGTT
TTCTTGGCAGATTTAAGACTTTAGTCATTTATAGCAAAAATCGACAAGATGGTGCACAGGGAGG
TGATACGAAAGAGGGGTCAGTGATGAGAACTACTGAGGAGAACATTGCCCTGCTGCAGGCGATC
GCATGCCTGTAAACTAGCCGCACTTGCCCCTGTGCTGGGGAGCTCTGTCGCCCTCTTAGAGCAG
CAGTGAGTTTGTTTGAGTGCTCATTTGTTTTATTTGTTTGTTTGTTTTTAAACCAGAAAGTCTA
TAAAGTTCCCAGGTTTAGTGGTCTGAGAGCGTGGACCAGGAGTATGCCCTGCAGGCACCCAGTA
CCTCTGAGAGGCAGGTCTGTGCTGTCGAGCTGCCCCAGCCTCTTCCACTTCCTGTGTCACCCCC
ATGGTTCAGATCTCTTCACTGTCTTTCTTCAGGACACCCCACACATTGCTCGACAGTCCTTGTT
GTCACACTGTGGCTGCAGCTGTCGCTGGCAGTGGCACTGTAAGCCCACACCGTGGAAGAGCCTG
AATTTAAAATAAGAAATAAATGCACACGTTGAAAACAAAT

hide sequence

RefSeq Acc Id:

XM_063274430 ⟹ XP_063130500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	51,040,665 - 51,068,449 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001388593	(Get FASTA)	NCBI Sequence Viewer
	NP_001388594	(Get FASTA)	NCBI Sequence Viewer
	XP_006252338	(Get FASTA)	NCBI Sequence Viewer
	XP_063130500	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM02187	(Get FASTA)	NCBI Sequence Viewer
	EDM02188	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000063756
	ENSRNOP00000063756.1
	ENSRNOP00000070148
	ENSRNOP00000070148.2
	ENSRNOP00000104975

RefSeq Acc Id:	XP_006252338 ⟸ XM_006252276
- Peptide Label:	isoform X1
- UniProtKB:	A6HTH4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIVVISILAAAVSLLYFSVVIIRSKYGWLSKD KKFQRYLARVTDVEATDTNNPNVNYGIVVDCGSSGSRIFVYCWPQHNGNPHDLLDIRQMRDKNR KPVVMKIKPGISEFATSPEKVSDYISPLLSFAAEHVPRAKHKETPLYILCTAGMRVLPESQQKA ILEDLLTDIPVHYDFLFSDSHAEVISGKQEGVYAWIGINFVLGRFEHIEEDDEAVVEVNIPGSE SSEAIVRKRTAGILDMGGVSTQIAYEVPKTVSFASSQQEEVAKNLLAEFNLGCDVHQTEHVYRV YVATFLGFGGNAARQRYEDRLFASTVQKNRLLGKQTGLTPDAPFLDPCLPLDLKDEIQQNGQTL YLRGTGDFDLCRETLQPFMNKTNETQTSLNGVYQPPIHFQNSEFYGFSEFYYCTEDVLRMGGDY NAAKFTKAAKDYCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHRGFSFPVTYKS LKTALQVYDKEVQWTLGAILYRTRFLPLRDIRQEVFRAGHAHWQGVSFVYNHYLFSGCFLVVLL SILLYLLRLRRIHRRAPRTGSLWMEEGLPSQKGPGPL hide sequence

Ensembl Acc Id:

ENSRNOP00000070148 ⟸ ENSRNOT00000088928

Ensembl Acc Id:

ENSRNOP00000063756 ⟸ ENSRNOT00000064428

RefSeq Acc Id:	NP_001388593 ⟸ NM_001401664
- Peptide Label:	isoform 1
- UniProtKB:	A6HTH4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001388594 ⟸ NM_001401665
- Peptide Label:	isoform 2
- UniProtKB:	A0A0G2JX61 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063130500 ⟸ XM_063274430
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2JX61 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JX61-F1-model_v2	AlphaFold	A0A0G2JX61	1-613	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699802

Promoter ID:

EPDNEW_R10321

Type:

initiation region

Name:

Entpd4_1

Description:

ectonucleoside triphosphate diphosphohydrolase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	51,223,010 - 51,223,070	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309511	AgrOrtholog
BioCyc Gene	G2FUF-13256	BioCyc
Ensembl Genes	ENSRNOG00000016321	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000064428	ENTREZGENE
	ENSRNOT00000064428.3	UniProtKB/TrEMBL
	ENSRNOT00000088928	ENTREZGENE
	ENSRNOT00000088928.2	UniProtKB/TrEMBL
	ENSRNOT00000143533	ENTREZGENE
Gene3D-CATH	3.30.420.40	UniProtKB/TrEMBL
	Exopolyphosphatase. Domain 2	UniProtKB/TrEMBL
InterPro	GDA1_CD39_NTPase	UniProtKB/TrEMBL
NCBI Gene	361063	ENTREZGENE
PANTHER	ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4	UniProtKB/TrEMBL
	GDA1_CD39_NTPase	UniProtKB/TrEMBL
Pfam	GDA1_CD39	UniProtKB/TrEMBL
PhenoGen	Entpd4	PhenoGen
PROSITE	GDA1_CD39_NTPASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016321	RatGTEx
UniProt	A0A0G2JX61	ENTREZGENE, UniProtKB/TrEMBL
	A6HTH4	ENTREZGENE, UniProtKB/TrEMBL
	D3ZZW3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Entpd4	ectonucleoside triphosphate diphosphohydrolase 4	Entpd4_predicted	ectonucleoside triphosphate diphosphohydrolase 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Entpd4_predicted	ectonucleoside triphosphate diphosphohydrolase 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)