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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nebivolol
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Accession:CHEBI:64022 term browser browse the term
Definition:A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Synonyms:related_synonym: (1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol;   (1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol};   dl-nebivolol;   nebivololum
 xref: CAS:118457-14-0;   DrugBank:DB04861;   KEGG:D05127
 xref_mesh: MESH:D000068577
 xref: PMID:17661735;   PMID:18078016;   PMID:18083889;   PMID:18221115;   PMID:18786089;   PMID:19443516;   PMID:19815121;   PMID:20620250;   PMID:23314750;   Patent:US4654362;   Reaxys:4789059;   Wikipedia:Nebivolol


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nebivolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding		 ISO
EXP		 Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Nebivolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Nebivolol binds to ADRB1 protein
Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Nebivolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]		 CTD PMID:2462161 PMID:12535855 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Nebivolol inhibits the reaction [AGT protein affects the localization of NCF2 protein]; Nebivolol inhibits the reaction [AGT protein results in decreased expression of VASP protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]; Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF1 mRNA]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF2 protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NOX1 protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of RAC1 protein] CTD PMID:16940222 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Ar androgen receptor increases expression
multiple interactions		 EXP
ISO		 Nebivolol results in increased expression of AR protein
Nebivolol binds to and results in decreased activity of AR protein		 CTD PMID:19962728 PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP [Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein] CTD PMID:30291735 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Cat catalase multiple interactions EXP Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]] CTD PMID:30291735 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
decreases secretion		 ISO Nebivolol results in decreased expression of CCL2 mRNA
Nebivolol results in decreased secretion of CCL2 protein		 CTD PMID:17310107 PMID:17467819 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBA mRNA] CTD PMID:16940222 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBB mRNA] CTD PMID:16940222 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions
increases activity
increases expression		 ISO Dactinomycin inhibits the reaction [Nebivolol results in increased expression of DDAH2 mRNA]
Nebivolol results in increased activity of DDAH2 protein
Nebivolol results in increased expression of DDAH2 mRNA; Nebivolol results in increased expression of DDAH2 protein		 CTD PMID:17977009 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Nebivolol results in increased expression of DHCR24 mRNA CTD PMID:17467819 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Edn1 endothelin 1 decreases secretion
decreases expression		 ISO Nebivolol results in decreased secretion of EDN1 protein
Nebivolol results in decreased expression of EDN1 mRNA		 CTD PMID:11078433 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nebivolol binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects activity
multiple interactions		 ISO Nebivolol affects the activity of ESR2 protein
Nebivolol binds to and results in decreased activity of ESR2 protein		 CTD PMID:19330906 PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Nebivolol results in decreased expression of ICAM1 mRNA CTD PMID:17310107 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Nebivolol results in decreased expression of IL1A mRNA CTD PMID:17467819 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF1 mRNA] CTD PMID:16940222 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein affects the localization of NCF2 protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF2 protein] CTD PMID:16940222 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Nebivolol results in increased expression of NFE2L2 CTD PMID:23886954 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos3 nitric oxide synthase 3 increases activity
increases expression
multiple interactions		 ISO
EXP		 Nebivolol results in increased activity of NOS3 protein
Nebivolol results in increased expression of NOS3
[Nebivolol co-treated with Flutamide] results in increased expression of NOS3 protein
Nebivolol results in increased expression of NOS3 protein		 CTD PMID:17977009 PMID:19962728 PMID:23886954 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of NOX1 protein] CTD PMID:16940222 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO Nebivolol results in increased expression of NPPB protein CTD PMID:18192850 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO Nebivolol results in decreased expression of PDGFA mRNA CTD PMID:17467819 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Nebivolol results in decreased expression of PDGFB mRNA CTD PMID:17310107 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Nebivolol binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 ISO 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of PPARGC1A protein] CTD PMID:23886954 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Nebivolol results in decreased expression of PTGS2 mRNA CTD PMID:17467819 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of RAC1 protein] CTD PMID:16940222 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Ren renin multiple interactions EXP Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein] CTD PMID:12806161 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Sele selectin E decreases expression ISO Nebivolol results in decreased expression of SELE mRNA CTD PMID:17310107 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selp selectin P decreases expression ISO Nebivolol results in decreased expression of SELP mRNA CTD PMID:17310107 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression		 ISO 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of SIRT3 protein] CTD PMID:23886954 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects expression		 ISO
EXP		 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol affects the expression of SOD2 protein]
Nebivolol inhibits the reaction [Daunorubicin results in decreased secretion of SOD2 protein]		 CTD PMID:18194856 PMID:23886954 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Nebivolol results in increased expression of TFAM CTD PMID:23886954 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Nebivolol binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Nebivolol results in decreased expression of TNFAIP6 mRNA CTD PMID:17467819 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP Nebivolol inhibits the reaction [Daunorubicin results in increased expression of TNNT2 protein] CTD PMID:18194856 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in decreased expression of VASP protein]; Nebivolol inhibits the reaction [Phorbol Esters results in decreased phosphorylation of VASP protein] CTD PMID:16940222 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Nebivolol results in decreased expression of VCAM1 mRNA CTD PMID:17310107 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 increases expression ISO Nebivolol results in increased expression of VIPR1 mRNA CTD PMID:17467819 NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      chemical substance 14383
        mixture 13700
          racemate 12076
            nebivolol 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  oxacycle 17866
                                    benzopyran 11952
                                      1-benzopyran 11704
                                        chromanes 4027
                                          2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] 40
                                            (R,S,S,S)-nebivolol 40
                                              nebivolol 40
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