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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncf2
Name: neutrophil cytosolic factor 2
Acc ID: CHEBI:64022
Term: nebivolol
Definition: A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Chemical ID: MESH:D000068577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDNebivolol inhibits the reaction [AGT protein affects the localization of NCF2 protein], Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF2 protein]

PMID:16940222
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.