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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions decreases expression |
ISO |
ICI 118551 inhibits the reaction [Formoterol Fumarate results in decreased expression of ACTA2 protein] Formoterol Fumarate results in decreased expression of ACTA2 mRNA; Formoterol Fumarate results in decreased expression of ACTA2 protein |
CTD |
PMID:21603974 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adrb1 |
adrenoceptor beta 1 |
multiple interactions |
ISO |
[Formoterol Fumarate binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Formoterol Fumarate binds to and results in increased activity of ADRB1 protein; Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB1 protein] |
CTD |
PMID:14730417 |
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NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259
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G |
Adrb2 |
adrenoceptor beta 2 |
multiple interactions affects expression increases phosphorylation increases activity |
ISO |
[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]; Formoterol Fumarate binds to and results in increased activity of ADRB2 protein; Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Formoterol Fumarate promotes the reaction [Cycloheximide results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA] Formoterol Fumarate results in increased phosphorylation of ADRB2 protein Formoterol Fumarate results in increased activity of ADRB2 protein |
CTD |
PMID:14722251 PMID:14730417 PMID:16980553 PMID:20061444 PMID:24705868 PMID:34601065 More...
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NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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G |
Adrb3 |
adrenoceptor beta 3 |
multiple interactions |
ISO |
[Formoterol Fumarate binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Formoterol Fumarate binds to and results in increased activity of ADRB3 protein; Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB3 protein] |
CTD |
PMID:14730417 |
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NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Formoterol Fumarate results in decreased expression of BCL2 mRNA; Formoterol Fumarate results in decreased expression of BCL2 protein |
CTD |
PMID:14687023 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
[Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CCL5 protein |
CTD |
PMID:15679717 |
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NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Cd44 |
CD44 molecule |
multiple interactions |
ISO |
Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] |
CTD |
PMID:18076728 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
[Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CSF2 protein |
CTD |
PMID:15679717 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Fgf2 |
fibroblast growth factor 2 |
multiple interactions |
ISO |
[Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] |
CTD |
PMID:18076728 |
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NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
ISO |
[Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] |
CTD |
PMID:18076728 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
ISO |
Formoterol Fumarate results in increased expression of IGF1 mRNA |
CTD |
PMID:36822333 |
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Il10 |
interleukin 10 |
decreases expression |
EXP |
Formoterol Fumarate results in decreased expression of IL10 mRNA |
CTD |
PMID:16908771 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il13 |
interleukin 13 |
multiple interactions |
EXP |
desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 protein] |
CTD |
PMID:26003274 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate] |
CTD |
PMID:20061444 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
multiple interactions |
EXP ISO |
desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]]; desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 protein]]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 protein]; Formoterol Fumarate promotes the reaction [desisobutyrylciclesonide inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]] Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] |
CTD |
PMID:18076728 PMID:26003274 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
affects expression multiple interactions increases expression |
EXP |
Formoterol Fumarate affects the expression of IL6 mRNA; Formoterol Fumarate affects the expression of IL6 protein Formoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Formoterol Fumarate results in increased expression of IL6 mRNA |
CTD |
PMID:10525314 PMID:11096136 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
Formoterol Fumarate results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Formoterol Fumarate results in increased phosphorylation of and results in increased activity of MAPK1 protein |
CTD |
PMID:15603589 PMID:16980553 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Formoterol Fumarate results in increased phosphorylation of and results in increased activity of MAPK3 protein |
CTD |
PMID:15603589 PMID:16980553 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[Formoterol Fumarate co-treated with desisobutyrylciclesonide] inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of MAPK8 protein]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:26003274 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:26003274 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP |
Budesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]]; Formoterol Fumarate inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]; Formoterol Fumarate promotes the reaction [Budesonide inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]]; Ipratropium promotes the reaction [Formoterol Fumarate inhibits the reaction [Cadmium results in increased activity of MMP9 protein]] |
CTD |
PMID:20826145 PMID:25313925 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases expression |
ISO |
Formoterol Fumarate results in increased expression of MTOR mRNA |
CTD |
PMID:36822333 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
[Beclomethasone co-treated with Formoterol Fumarate] affects the localization of NR3C1 protein |
CTD |
PMID:15679717 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
increases expression |
ISO |
Formoterol Fumarate results in increased expression of PIK3R1 mRNA |
CTD |
PMID:36822333 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
increases expression |
ISO |
Formoterol Fumarate results in increased expression of PRKAA2 mRNA |
CTD |
PMID:36822333 |
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NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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G |
Rnase3 |
ribonuclease A family member 3 |
decreases expression |
ISO |
Formoterol Fumarate results in decreased expression of RNASE3 protein |
CTD |
PMID:1443864 |
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NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions increases uptake |
ISO |
Budesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [beclomethasone 17-monopropionate results in decreased transport of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Budesonide results in decreased transport of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [desisobutyrylciclesonide results in decreased transport of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate] |
CTD |
PMID:17920670 PMID:21914487 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Thy1 |
Thy-1 cell surface antigen |
multiple interactions |
ISO |
Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] |
CTD |
PMID:18076728 |
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NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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G |
Tnf |
tumor necrosis factor |
affects expression multiple interactions |
EXP ISO |
Formoterol Fumarate affects the expression of TNF mRNA; Formoterol Fumarate affects the expression of TNF protein [TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate] Formoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Formoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:10525314 PMID:11096136 PMID:20061444 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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