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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:31633
Term: formoterol fumarate
Definition: A racemate consisting of equal amounts of arformoterol fumarate (the active enantiomer) and (S,S)-formoterol fumarate (the inactive enantiomer). It is used (particularly in its dihydrate form) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
Chemical ID: MESH:D000068759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2decreases expressionISORGD:13483516480464CTDFormoterol Fumarate results in decreased expression of ACTA2 mRNA Formoterol Fumarate results in decreased expression of ACTA2 protein

PMID:21603974
Acta2multiple interactionsISORGD:13483516480464CTDICI 118551 inhibits the reaction [Formoterol Fumarate results in decreased expression of ACTA2 protein]

PMID:21603974
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