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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3701
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a3
Name: solute carrier family 22 member 3
Acc ID: CHEBI:31633
Term: formoterol fumarate
Definition: A racemate consisting of equal amounts of arformoterol fumarate (the active enantiomer) and (S,S)-formoterol fumarate (the inactive enantiomer). It is used (particularly in its dihydrate form) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
Chemical ID: MESH:D000068759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a3increases uptakeISORGD:13518286480464CTDSLC22A3 protein results in increased uptake of Formoterol Fumarate

PMID:17920670
Slc22a3multiple interactionsISORGD:13518286480464CTDBudesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate] Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate] Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate] SLC22A3 protein results in increased susceptibility to [beclomethasone 17-monopropionate results in decreased transport of Formoterol Fumarate] SLC22A3 protein results in increased susceptibility to [Budesonide results in decreased transport of Formoterol Fumarate] SLC22A3 protein results in increased susceptibility to [desisobutyrylciclesonide results in decreased transport of Formoterol Fumarate] SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate]

PMID:17920670 PMID:21914487
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