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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2609
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf2
Name: fibroblast growth factor 2
Acc ID: CHEBI:31633
Term: formoterol fumarate
Definition: A racemate consisting of equal amounts of arformoterol fumarate (the active enantiomer) and (S,S)-formoterol fumarate (the inactive enantiomer). It is used (particularly in its dihydrate form) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
Chemical ID: MESH:D000068759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf2multiple interactionsISORGD:708226480464CTD[Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]] Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] Formoterol Fumarate promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein]

PMID:18076728
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