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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:31633
Term: formoterol fumarate
Definition: A racemate consisting of equal amounts of arformoterol fumarate (the active enantiomer) and (S,S)-formoterol fumarate (the inactive enantiomer). It is used (particularly in its dihydrate form) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
Chemical ID: MESH:D000068759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6affects expressionEXP 6480464CTDFormoterol Fumarate affects the expression of IL6 mRNA Formoterol Fumarate affects the expression of IL6 protein

PMID:10525314
Il6increases expressionEXP 6480464CTDFormoterol Fumarate results in increased expression of IL6 mRNA

PMID:11096136
Il6multiple interactionsEXP 6480464CTDFormoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:10525314
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