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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:anti-estrogen
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Accession:CHEBI:50751 term browser browse the term
Definition:A drug which acts to reduce estrogenic activity in the body, either by reducing the amount of estrogen or by reducing the activity of whatever estrogen is present.
Synonyms:related_synonym: anti-estrogenic agent;   anti-estrogenic drug;   anti-oestrogen;   anti-oestrogenic agent;   anti-oestrogenic drug;   antiestrogen;   antiestrogenic agent;   antiestrogenic drug;   antioestrogen;   antioestrogenic agent;   antioestrogenic drug
 xref: Wikipedia:Antiestrogen


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danazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity ISO Danazol results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Danazol results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Ankrd40 ankyrin repeat domain 40 increases expression ISO Danazol results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:94,218,827...94,232,673
Ensembl chr11:94,218,827...94,232,667 		JBrowse link
G Ar androgen receptor increases activity
multiple interactions		 ISO Danazol results in increased activity of AR protein
Danazol binds to and results in decreased activity of AR protein; Danazol binds to and results in increased activity of AR protein		 CTD PMID:12730620 PMID:21543282 PMID:25752796 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G C3 complement component 3 increases expression ISO Danazol results in increased expression of C3 protein CTD PMID:4014294 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Danazol results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cfb complement factor B increases expression ISO Danazol results in increased expression of CFB protein CTD PMID:4014294 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein] CTD PMID:15866594 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Danazol results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 decreases activity ISO Danazol results in decreased activity of CYP2J2 protein CTD PMID:29689254 PMID:30965050 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Danazol binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Fshb follicle stimulating hormone beta decreases expression ISO Danazol results in decreased expression of FSHB protein CTD PMID:3088269 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions		 ISO Danazol results in decreased activity of HSD11B2 protein
Danazol inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]		 CTD PMID:22273746 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL10 mRNA CTD PMID:18007553 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL6 mRNA CTD PMID:18007553 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Lhb luteinizing hormone beta decreases expression ISO Danazol results in decreased expression of LHB protein CTD PMID:3088269 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein] CTD PMID:15866594 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Danazol binds to and results in decreased activity of PGR protein; Danazol binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Prl prolactin multiple interactions ISO Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] CTD PMID:4087275 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 increases expression ISO Danazol results in increased expression of SERPING1 protein CTD PMID:4014294 NCBI chr 2:84,595,704...84,605,748
Ensembl chr 2:84,595,731...84,605,788 		JBrowse link
G Sts steroid sulfatase decreases activity ISO Danazol results in decreased activity of STS protein CTD PMID:11600235 NCBI chr  X:168,856,332...169,015,037
Ensembl chr  X:168,909,030...169,014,924 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]
[peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of TNF mRNA		 CTD PMID:15866594 PMID:18007553 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
ICI-164384 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor multiple interactions ISO ICI 164384 inhibits the reaction [EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]] CTD PMID:21048224 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO ICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA] CTD PMID:18629630 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) affects binding
multiple interactions		 ISO
EXP		 ICI 164384 binds to ESR1 protein
[ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA; ICI 164384 binds to and results in increased activity of ESR1 protein		 CTD PMID:11162928 PMID:11174852 PMID:19913605 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) affects binding ISO ICI 164384 binds to ESR2 protein CTD PMID:19913605 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Hspb1 heat shock protein 1 multiple interactions ISO [ICI 164384 binds to and results in increased activity of ESR1 protein] which results in increased expression of HSPB1 mRNA CTD PMID:11174852 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO ICI 164384 inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK1 protein] CTD PMID:15712295 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO ICI 164384 inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK3 protein] CTD PMID:15712295 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Olfm4 olfactomedin 4 multiple interactions ISO ICI 164384 inhibits the reaction [EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]] CTD PMID:21048224 NCBI chr14:80,237,742...80,260,581
Ensembl chr14:80,221,521...80,260,579 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Cadmium results in increased expression of PGR protein]; ICI 164384 inhibits the reaction [Endosulfan results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of PGR mRNA] CTD PMID:8207012 PMID:16242299 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Prl prolactin multiple interactions ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PRL mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of PRL mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of PRL mRNA] CTD PMID:8968093 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 multiple interactions
affects response to substance
decreases expression		 ISO ICI 164384 inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]
SIAH2 protein affects the susceptibility to ICI 164384
ICI 164384 results in decreased expression of SIAH2 mRNA		 CTD PMID:18629630 NCBI chr 3:58,582,370...58,599,857
Ensembl chr 3:58,582,359...58,599,821 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Endosulfan results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [phenothrin results in increased expression of TFF1 mRNA] CTD PMID:8968093 PMID:10064545 PMID:16242299 NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO ICI 164384 inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; ICI 164384 inhibits the reaction [Estradiol results in increased expression of TP53 protein] CTD PMID:31681507 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
leuprolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:17143537 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO Leuprolide results in increased expression of BAX protein CTD PMID:15965100 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression ISO Leuprolide results in increased expression of BCL2 mRNA CTD PMID:18829022 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Casp3 caspase 3 increases expression ISO Leuprolide results in increased expression of CASP3 protein CTD PMID:15965100 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 increases expression ISO Leuprolide results in increased expression of CASP9 protein CTD PMID:15965100 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cldn4 claudin 4 decreases expression ISO Leuprolide results in decreased expression of CLDN4 protein CTD PMID:21761342 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788 		JBrowse link
G Cldn8 claudin 8 decreases expression ISO Leuprolide results in decreased expression of CLDN8 protein CTD PMID:21761342 NCBI chr16:88,357,714...88,360,071
Ensembl chr16:88,357,716...88,360,071 		JBrowse link
G Cycs cytochrome c, somatic affects localization
increases expression		 ISO Leuprolide affects the localization of CYCS protein
Leuprolide results in increased expression of CYCS mRNA		 CTD PMID:15965100 PMID:18829022 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP [Leuprolide co-treated with Testosterone] results in decreased expression of CYP19A1 mRNA CTD PMID:16032706 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions EXP [Leuprolide co-treated with Testosterone] results in decreased expression of FSHR mRNA CTD PMID:16032706 NCBI chr17:89,292,380...89,508,103
Ensembl chr17:89,292,380...89,508,103 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:17143537 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions ISO Leuprolide results in decreased expression of and results in decreased phosphorylation of IGF1R protein CTD PMID:17143537 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO Leuprolide inhibits the reaction [resveratrol results in decreased expression of IL6 protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of IL6 protein] CTD PMID:25462211 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] CTD PMID:17143537 NCBI chr15:103,252,713...103,275,218
Ensembl chr15:103,252,713...103,275,190 		JBrowse link
G Itgb3 integrin beta 3 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] CTD PMID:17143537 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Lhb luteinizing hormone beta decreases expression ISO Leuprolide results in decreased expression of LHB protein CTD PMID:10221860 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions
decreases expression		 EXP [Leuprolide co-treated with Testosterone] results in decreased expression of LHCGR mRNA
Leuprolide results in decreased expression of LHCGR mRNA		 CTD PMID:16032706 NCBI chr17:89,023,812...89,099,487
Ensembl chr17:89,023,909...89,099,418 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO Leuprolide inhibits the reaction [resveratrol results in decreased expression of MMP2 protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP2 protein] CTD PMID:25462211 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO Leuprolide results in decreased expression of MMP9 protein
Leuprolide inhibits the reaction [resveratrol results in decreased expression of MMP9 protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP9 protein]		 CTD PMID:25462211 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Leuprolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO Leuprolide inhibits the reaction [resveratrol results in decreased expression of TNF protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of TNF protein] CTD PMID:25462211 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO Leuprolide results in decreased expression of VEGFA protein
Leuprolide inhibits the reaction [resveratrol results in decreased expression of VEGFA protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of VEGFA protein]		 CTD PMID:25462211 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
RU 58668 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO [RU 58668 results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA CTD PMID:19901195 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 affects expression ISO RU 58668 affects the expression of BCL2 protein CTD PMID:15868441 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO RU 58668 results in increased expression of CYP1A1 mRNA
[RU 58668 results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; RU 58668 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:18493746 PMID:19901195 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO RU 58668 inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; RU 58668 promotes the reaction [fulvestrant inhibits the reaction [Genistein results in increased activity of ESR1 protein]]; RU 58668 results in decreased stability of and results in decreased expression of ESR1 protein CTD PMID:15868441 PMID:20599613 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Igf1r insulin-like growth factor I receptor affects expression ISO RU 58668 affects the expression of IGF1R protein CTD PMID:15868441 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression ISO RU 58668 affects the expression of IGFBP2 protein CTD PMID:15868441 NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633 		JBrowse link
G Pgr progesterone receptor affects expression ISO RU 58668 affects the expression of PGR protein CTD PMID:15868441 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22192
    role 22175
      application 21778
        pharmaceutical 21197
          drug 21197
            anti-estrogen 52
              9,9-bis(4-hydroxyphenyl)fluorene 0
              ICI-164384 13
              RU 58668 7
              clomiphene citrate 0
              danazol 21
              elacestrant 0
              furowanin B 0
              glyceollin III 0
              leuprolide + 22
              millewanin G 0
              millewanin H 0
              monoisopropyl phthalate 0
              monopentyl phthalate 0
              nafarelin + 0
              nafarelin acetate + 0
              nafarelin acetate hydrate 0
              tamoxifen N-oxide 0
paths to the root